1978
DOI: 10.1016/0009-8981(78)90388-1
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Post-synthetic changes in creatine kinase isozymes (EC 2.7.3.2)

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Cited by 72 publications
(11 citation statements)
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“…Our findings contradict recent data indicating that only one type of the creatine ; kinase-MM and creatine kinase-MB isoenzyme is present in the cytoplasm of the human skeletal and heart m scle cell (21). The reason for this contradiction could be either poor sensitivity of the methods used, or inactivation of creatine kinase isoenzymes, since creatine kinase isoenzymes undergo reversible and irreversible inactivation in response to oxidation and temperature, respectively (22,23).…”
Section: Discussioncontrasting
confidence: 98%
See 1 more Smart Citation
“…Our findings contradict recent data indicating that only one type of the creatine ; kinase-MM and creatine kinase-MB isoenzyme is present in the cytoplasm of the human skeletal and heart m scle cell (21). The reason for this contradiction could be either poor sensitivity of the methods used, or inactivation of creatine kinase isoenzymes, since creatine kinase isoenzymes undergo reversible and irreversible inactivation in response to oxidation and temperature, respectively (22,23).…”
Section: Discussioncontrasting
confidence: 98%
“…The reason for this contradiction could be either poor sensitivity of the methods used, or inactivation of creatine kinase isoenzymes, since creatine kinase isoenzymes undergo reversible and irreversible inactivation in response to oxidation and temperature, respectively (22,23). Using polyacrylamide, some authors were unable to detect m ny forms of creatine kinase in cardiac tissue extracts (21,24). This could be due to the presence of persisting free radicals generated by ammonium persulphate.…”
Section: Discussionmentioning
confidence: 99%
“…All three parameters can be used as an index for the mean age of the CK M-chain in the blood. It is to be expected that the modifying protein also influences the physicochemical characteristics of the CK MB isozyme [2]. Our data show that there are measurable changes in the Michaelis-Menten constants due to changes in the temperature of the assay.…”
Section: Discussionmentioning
confidence: 64%
“…The ageing of the enzyme can be attributed to a modification in the M-chain caused by a serum protein [1,2], for which the name CK conversion factor has been proposed [3]. As the same protein modifies the alpha chain of enolase as well [7], the name modifying protein was introduced by Wevers et al [7], Recently, the modifying protein has been shown to have carboxypeptidase activity [8,9].…”
Section: Introductionmentioning
confidence: 99%
“…The existence of three MM-and two MB-fofms can be explained by this modification (21). The existence of three MM-and two MB-fofms can be explained by this modification (21).…”
Section: The Binding Between Cfeätine Kinase-bb Andmentioning
confidence: 92%