Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview

Sharma, B. Sharan; Prabhakaran, Vaishna; Desai, Akash P; Bajpai, A. K.; Verma, Ramtej J.; Swain, Prabodha K.

doi:10.35702/onc.10012

Cited by 30 publications

(24 citation statements)

References 102 publications

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“…It is expected that the PTM assisted enriching strategy has the potential to facilitate personalized cancer immunotherapy in other cancer types. 63 For example, colon cancer is reported to have aberrantly glycosylated cancer associated antigens, 64 which can be enriched through the glycoprotein enriching strategies reported previously. 65 Therefore, nanoparticles with specic enriching capability towards a PTM type can be designed for targeting tumor antigens in various cancer types according to their PTM signatures.…”

Section: Discussionmentioning

confidence: 99%

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

et al. 2020

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Section: Discussionmentioning

confidence: 99%

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

et al. 2020

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“…PTM has different categories and is very prevalent in the cells. More than 450 categories of PTMs were discovered to date, such as phosphorylation, methylation, and acetylation [1][2][3]. PTM increases diversity of protein structures and functions, viewed as one of most regulating mechanisms in the cellular process.…”

Section: Introductionmentioning

confidence: 99%

LSTMCNNsucc: A Bidirectional LSTM and CNN-Based Deep Learning Method for Predicting Lysine Succinylation Sites

Huang

Zhang

et al. 2021

BioMed Research International

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Lysine succinylation is a typical protein post-translational modification and plays a crucial role of regulation in the cellular process. Identifying succinylation sites is fundamental to explore its functions. Although many computational methods were developed to deal with this challenge, few considered semantic relationship between residues. We combined long short-term memory (LSTM) and convolutional neural network (CNN) into a deep learning method for predicting succinylation site. The proposed method obtained a Matthews correlation coefficient of 0.2508 on the independent test, outperforming state of the art methods. We also performed the enrichment analysis of succinylation proteins. The results showed that functions of succinylation were conserved across species but differed to a certain extent with species. On basis of the proposed method, we developed a user-friendly web server for predicting succinylation sites.

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“…The importance of posttranslational modifications in tumorigenesis is widely accepted [ 6 , 7 , 8 ]. Insight in these processes can lead to new therapeutic strategies to improve current treatments [ 8 ]. Ubiquitination is, besides phosphorylation, an important posttranslational modification linked to cancer.…”

Section: Introductionmentioning

confidence: 99%

Structure–Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors

Elsocht

Giron

Maes

et al. 2021

IJMS

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Lung cancer is one of the most frequently diagnosed cancers accounting for the highest number of cancer-related deaths in the world. Despite significant progress including targeted therapies and immunotherapy, the treatment of advanced lung cancer remains challenging. Targeted therapies are highly efficacious at prolonging life, but not curative. In prior work we have identified Ubiquitin Specific Protease 13 (USP13) as a potential target to significantly enhance the efficacy of mutant EGFR inhibition. The current study aimed to develop lead molecules for the treatment of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) by developing potent USP13 inhibitors initially starting from Spautin-1, the only available USP13 inhibitor. A SAR study was performed which revealed that increasing the chain length between the secondary amine and phenyl group and introducing a halogen capable of inducing a halogen bond at position 4’ of the phenyl group, dramatically increased the activity. However, we could not confirm the binding between Spautin-1 (or its analogues) and USP13 using isothermal titration calorimetry (ITC) or thermal shift assay (TSA) but do not exclude binding under physiological conditions. Nevertheless, we found that the anti-proliferative activity displayed by Spautin-1 towards EGFR-mutant NSCLC cells in vitro was at least partially associated with kinase inhibition. In this work, we present N-[2-(substituted-phenyl)ethyl]-6-fluoro-4-quinazolinamines as promising lead compounds for the treatment of NSCLC. These analogues are significantly more effective towards EGFR-mutant NSCLC cells than Spautin-1 and act as potent never in mitosis A related kinase 4 (NEK4) inhibitors (IC50~1 µM) with moderate selectivity over other kinases.

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Post-translational Modifications (PTMs), from a Cancer Perspective: An Overview

Cited by 30 publications

References 102 publications

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

Post translational modification-assisted cancer immunotherapy for effective breast cancer treatment

LSTMCNNsucc: A Bidirectional LSTM and CNN-Based Deep Learning Method for Predicting Lysine Succinylation Sites

Structure–Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors

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