Post-transplant diabetes mellitus

Abstract

In recent decades, Diabetes Mellitus has become a severe and growing global public healthcare problem due to the increase of its prevalence, morbidity and mortality. Post-transplant diabetes mellitus (PTDM) is a complication which takes place after a solid organ transplant, and its incidence is widely variable, ranging from 2 to 53%. Some factors increase the risk of PTDM, such as age, ethnicity, cadaver-donor kidney presence of the hepatitis C virus and cytomegalovirus, overweight and obesity and the Immunosuppression scheme established in the immediate post-transplant period. High doses of tacrolimus and corticosteroid represent the highest risk for developing PTDM.Considering that the development of PTDM is associated with a higher risk of complications, such as infections and cardiovascular disease -thus representing a higher life threatening risk and a higher cost for the Health System -the relevance of identifying the risk factors and of the early diagnosis combined with appropriate therapy will be high for the follow up, and eventually resulting in the success of the procedure as far as patient survival and transplantation durability.

Liver Transplantation: A Potential Cure for Hepatogenous Diabetes?

“…Although current evidence suggests that immunosuppressive agents generally increase risk of diabetes after organ transplantations (2), our observations strengthen previous findings (3,4) of hepatogenous diabetes resolution after LT in some of the cyclosporine-treated patients with post–hepatitis B or C cirrhosis. It is important to point out that tacrolimus rather than cyclosporine is associated with hyperglycemia, one of the main side effects ascribed to reduced insulin secretion (5).…”

Adverse Reactions of Immunosuppressive Drugs in Iranian Adult Kidney Transplant Recipients

“…The therapeutic approach for patients with PTDM is generally the same as that recommended by ADA for type 2 diabetes mellitus. 38 More than 80% of our patients with PTDM received insulin, oral hypoglycemic agents, or a combination of insulin-oral hypoglycemic agents for controlling their diabetes.…”

Retrospektywna analiza zakażeń u pacjentów po przeszczepieniu nerki

“…Retrospektywna analiza zakażeń u pacjentów po przeszczepieniu nerki trzustkowych, przez co przyczyniają się do rozwoju zaburzeń gospodarki węglowodanowej [33,34]. Cukrzyca stanowi istotny czynnik ryzyka zakażeń bakteryjnych i grzybiczych po przeszczepieniu nerki [9,21,34].…”

“…Cukrzyca stanowi istotny czynnik ryzyka zakażeń bakteryjnych i grzybiczych po przeszczepieniu nerki [9,21,34]. Według doniesień Sumrani i wsp.…”