Post-transplant leukemia relapse in organs: biology. and behavior in 585 reports

Cunningham, Isabel

doi:10.1016/j.critrevonc.2020.103170

Cited by 6 publications

(7 citation statements)

References 92 publications

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“…Acute leukemia (AL) is a heterogeneous malignant clonal disease of hematopoietic stem cells, with a high recurrence rate and mortality rate [ 1 ]. Leukemia is mainly because of hematopoietic stem cells during differentiation and infiltrating the tissues and organs of the human body.…”

Section: Introductionmentioning

confidence: 99%

Two Different Transplant Preconditioning Regimens Combined with Irradiation and Chemotherapy in the Treatment of Childhood Leukemia: Systematic Review and Meta-Analysis

Wang

Geng

et al. 2022

Journal of Healthcare Engineering

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Objective. To observe the therapeutic effect and the incidence of adverse reactions of total body irradiation plus cyclophosphamide (TBI/CY) and busulfan plus cyclophosphamide (BU/CY) in the treatment of pediatric hematopoietic stem cell transplantation. Methods. By searching the Cochrane Library, PubMed, Web of Knowledge, Embase, Chinese Biomedical Literature Database (CBM), and screening randomized controlled trials (RCTs), quality evaluation and data extraction were performed for the included literature, and meta-analysis was performed for RCTs included at using Review Manager 5.2 software. Results. A total of 10160 patients were enrolled in 15 RCTs, including 5211 patients in the TBI/CY group and 4949 patients in the BU/CY group. Meta-analysis showed that there was a statistical difference in transplant failure rate (OR = 1.56, 95% CI (1.23, 1.97), P = 0.0002, I2 = 56%, Z = 3.69), transplant mortality (OR = 1.45, 95% CI (1.24, 1.68), P < 0.00001, I2 = 76%, Z = 4.80), transplantation long-term disease-free survival rate (OR = 1.52, 95% CI (1.09, 2.12), P = 0.01, I2 = 0%, Z = 2.50), and transplantation adverse reactions (OR = 1.28, 95% CI (1.08, 1.52), P = 0.004, I2 = 0%, Z = 2.85). Conclusion. Meta-analysis showed that TBI/CY combined pretreatment regimen was more effective than BU/CY regimen alone in the treatment of pediatric hematologic transplantation, with a lower incidence of adverse reactions and significant long-term survival efficacy.

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Section: Introductionmentioning

confidence: 99%

Two Different Transplant Preconditioning Regimens Combined with Irradiation and Chemotherapy in the Treatment of Childhood Leukemia: Systematic Review and Meta-Analysis

Wang

Geng

et al. 2022

Journal of Healthcare Engineering

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“…Reasons for this discordant are unclear. Cunningham et al attribute them to gene or microenvironmental deregulations [ 20 , 28 , 29 ], but that is continued to be studied.…”

Section: Discussionmentioning

confidence: 99%

The myeloid sarcoma treated by Venetoclax with hypomethylating agent followed by stem cell transplantation: rare case report

et al. 2021

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Background Myeloid sarcoma (MS) is a very rare condition, develops both in patients with other hematological neoplasms, and as isolated tumor. MS of the gynecologic tract is extremely rare. An available literature data about diagnosis and management of MS is summarized in the article. The role of chemotherapy, radiation therapy, surgery and bone marrow transplantation in the treatment is discussed. Polychemotherapy and allogeneic bone marrow transplantation were suggested to be the optimal treatment strategy of MS of the gynecological tract. The use of new targeted agents results in promising clinical data. Case presentation We are presenting a rare clinical case of a MS of the uterine cervix with concomitant bone marrow involvement and describe all the peculiarities of the clinical course, diagnosis, and treatment. The patient received chemotherapy followed by allogeneic bone marrow transplantation. The pre-transplant therapy allowed us to perform allogeneic bone marrow transplantation with the deepest response possible: complete PET-negative and MRD-negative remission of the disease. Conclusions MS remains a subject of discussion regarding its diagnostic and therapeutic aspects. The use of novel targeting agents can be perspective option for patient with extramedullary disease.

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“…High percentages of reported post-transplant extramedullary relapses in organs occur without systemic disease relapse. 51,52 Relapse in breast without marrow relapse was reported in 2 cases of transplant for myeloma 53,54 and 82 transplanted for leukemia (32 ALL and 50 AML). 51 In published experience, most cases of post-transplant relapse as tumors initially treated with systemic agents, without excision or surgery, did not achieve eradication of tumors or prevention of spread, and many cases of fatal aplasia of normal donor marrow occurred.…”

Section: Independent Growth Of Extramedullary Tumorsmentioning

confidence: 99%

“…51,52 Relapse in breast without marrow relapse was reported in 2 cases of transplant for myeloma 53,54 and 82 transplanted for leukemia (32 ALL and 50 AML). 51 In published experience, most cases of post-transplant relapse as tumors initially treated with systemic agents, without excision or surgery, did not achieve eradication of tumors or prevention of spread, and many cases of fatal aplasia of normal donor marrow occurred. 51 Tumor resistance to chemotherapy is also documented in cases where relapse after chemotherapy or transplant occurs simultaneously in extramedullary sites and marrow in both leukemia and myeloma.…”

Section: Independent Growth Of Extramedullary Tumorsmentioning

confidence: 99%

“…51 In published experience, most cases of post-transplant relapse as tumors initially treated with systemic agents, without excision or surgery, did not achieve eradication of tumors or prevention of spread, and many cases of fatal aplasia of normal donor marrow occurred. 51 Tumor resistance to chemotherapy is also documented in cases where relapse after chemotherapy or transplant occurs simultaneously in extramedullary sites and marrow in both leukemia and myeloma. In many of these reports, asynchronous response is noted: systemic therapy achieves remission in the marrow but not in tumor.…”

Section: Independent Growth Of Extramedullary Tumorsmentioning

confidence: 99%

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Single organ microenvironment and the common features of tumors of leukemia, lymphoma, and myeloma cells growing there: A literature review

Cunningham

Sosa²,

Hamele‐Bena

2021

European J of Haematology

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The tumor manifestations of leukemia, lymphoma, and multiple myeloma in body organs have been described for over a century.While the natural histories of each type of solid tumor is well known, that of hematologic tumors in the same organ site have not been elucidated. Knowledge of hematologic tumors has been limited to their description in individual case reports of tumors in any organ.The natural history of hematologic tumors in individual sites and their metastatic patterns has not been tracked, except for tumors at a few sites. Similar patterns of growth and spread between leukemic and solid tumors in breast, ovary, and GI sites were revealed. [1][2][3] Extensive studies of leukemic breast tumors and specimen analyses found histologic and genetic similarities of leukemic to solid breast cancers. 4 The present literature review was undertaken to ascertain

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Post-transplant leukemia relapse in organs: biology. and behavior in 585 reports

Cited by 6 publications

References 92 publications

Two Different Transplant Preconditioning Regimens Combined with Irradiation and Chemotherapy in the Treatment of Childhood Leukemia: Systematic Review and Meta-Analysis

Two Different Transplant Preconditioning Regimens Combined with Irradiation and Chemotherapy in the Treatment of Childhood Leukemia: Systematic Review and Meta-Analysis

The myeloid sarcoma treated by Venetoclax with hypomethylating agent followed by stem cell transplantation: rare case report

Single organ microenvironment and the common features of tumors of leukemia, lymphoma, and myeloma cells growing there: A literature review

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