Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen.

Hadley, Terence J.; Lü, Zhaohui; Waśniowska, Kazimiera; Martin, A. W.; Peiper, Stephen C.; Hesselgesser, Joseph; Horuk, Richard

doi:10.1172/jci117465

Cited by 201 publications

(120 citation statements)

References 43 publications

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“…Further studies revealed that a chemokinebinding protein expressed on red blood cells is identical to the Duffy antigen, which was subsequently renamed Duffy antigen receptor for chemokines (DARC) (74). DARC nonselectively binds the ELR ϩ CXC chemokines IL-8, GRO-␣ (MGSA), and NAP-2 as well as the nonangiogenic CC chemokines RANTES (regulated on activation normal T cell expressed and secreted) and MCP-1 with comparably high affinity (75).…”

Section: Fig 5 Il-8 Is a Potent Chemoattractant For Himec Migrationmentioning

confidence: 99%

Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

Heidemann¹,

Ogawa²,

Dwinell³

et al. 2003

Journal of Biological Chemistry

432

321

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Section: Fig 5 Il-8 Is a Potent Chemoattractant For Himec Migrationmentioning

confidence: 99%

Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

Heidemann¹,

Ogawa²,

Dwinell³

et al. 2003

Journal of Biological Chemistry

432

321

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“…The Duffy antigen receptor for chemokines (DARC) is less specific and binds members of both CXC and CC chemokines with medium affinity [29,30]. The activity of the E38A analog was assessed by measuring the elastase release from neutrophils (Fig.…”

Section: Assignmentmentioning

confidence: 99%

¹H NMR evidence that Glu‐38 interacts with the N‐terminal functional domain in interleukin‐8

et al. 1996

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In order to assess the importance of the buried Glu-38 observed in the structure of interleukin-8, an analog in which Glu-38 was replaced with Ala (E38A analog) was investigated by 'H NMR spectroscopy and neutrophil activation. Detailed analysis of the NMR NOESY data showed that the solution structure of the E38A analog is essentially the same as that for the native protein. Also, the neutrophil elastase activity of the E38A analog was similar to that of the native protein. However, the Gln-8 and Cys-9 amide proton chemical shifts, which are significantly downfield-shifted in the native protein, exhibit more 'normal' values. This observation indicates that in the native protein, Glu-38 side-chain carboxylate interacts with Gln-8 and Cys-9 amide protons. Although the N-terminal residues are critical for function, this interaction is not essential for neutrophil activation.

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“…The Duffy antigen/receptor for chemokines (DARC) is expressed on red blood cells (RBCs), where it acts as the receptor for malarial parasites Plasmodium vivax and P. knowlesi (which infects primarily primates); it is also expressed on endothelial cells of postcapillary venules, Purkinje cells of the cerebellum, kidney epithelial cells lining collection tubules, and type I pneumocytes of the lung (8)(9)(10)(11). A point mutation in a consensus binding site of the erythroid transcription factor GATA1 in the DARC promoter (T-46C) selectively decreases DARC expression on RBCs with a gene dosage effect (12).…”

mentioning

confidence: 99%

Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations

Vergara¹,

Tsai²,

Grant³

et al. 2008

Am J Respir Crit Care Med

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Rationale: Asthma prevalence and severity are high among underserved minorities, including those of African descent. The Duffy antigen/receptor for chemokines is the receptor for Plasmodium vivax on erythrocytes and functions as a chemokine-clearing receptor. Unlike European populations, decreased expression of the receptor on erythrocytes is common among populations of African descent, and results from a functional T-46C polymorphism (rs2814778) in the promoter. This variant provides an evolutionary advantage in malaria-endemic regions, because Duffy antigen/receptor for chemokines-negative erythrocytes are more resistant to infection by P. vivax. Objectives: To determine the role of the rs2814778 polymorphism in asthma and atopy as measured by total serum IgE levels among four populations of African descent (African Caribbean, African American, Brazilian, and Colombian) and a European American population. Methods: Family-based association tests were performed in each of the five populations to test for association between the rs2814778 polymorphism and asthma or total IgE concentration. Measurements and Main Results: Asthma was significantly associated with the rs2814778 polymorphism in the African Caribbean, Colombian, and Brazilian families (P , 0.05). High total IgE levels were associated with this variant in African Caribbean and Colombian families (P , 0.05). The variant allele was not polymorphic among European Americans. Conclusions: Susceptibility to asthma and atopy among certain populations of African descent is influenced by a functional polymorphism in the gene encoding Duffy antigen/receptor for chemokines. This genetic variant, which confers resistance to malarial parasitic infection, may also partially explain ethnic differences in morbidity of asthma.

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Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen.

Abstract: The human erythrocyte chemokine receptor has recently been shown to be identical to Invest. 1994.94:985-991.)

Cited by 201 publications

References 43 publications

Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

¹H NMR evidence that Glu‐38 interacts with the N‐terminal functional domain in interleukin‐8

Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations

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Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen.

Abstract: The human erythrocyte chemokine receptor has recently been shown to be identical to Invest. 1994.94:985-991.)

Cited by 201 publications

References 43 publications

Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

Angiogenic Effects of Interleukin 8 (CXCL8) in Human Intestinal Microvascular Endothelial Cells Are Mediated by CXCR2

1H NMR evidence that Glu‐38 interacts with the N‐terminal functional domain in interleukin‐8

Gene Encoding Duffy Antigen/Receptor for Chemokines Is Associated with Asthma and IgE in Three Populations

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¹H NMR evidence that Glu‐38 interacts with the N‐terminal functional domain in interleukin‐8