Poster session Friday 13 December - PM: 13/12/2013, 14:00-18:00 * Location: Poster area

Weightlessness and Cardiac Rhythm Disorders: Current Knowledge from Space Flight and Bed-Rest Studies

“…Similar results were observed in 38 astronauts before and after 9-16 days of spaceflights, where a reduction of 10% in LV mass and LV end-diastolic volume measured immediately after landing was completely reversed after 3 days (Summers et al, 2005). Also, in multiple HDBR studies after 14-days (Levine et al, 1997), 21-days (Carrick-Ranson et al, 2013Caiani et al, 2013c), and5-weeks (Kozakova et al, 2011;Hastings et al, 2012), the LV mass was found reduced. As in humans the reductions in LV load require a minimum of 6 months to result in statistically significant changes in LV mass (Dunn et al, 1987), and as the observed changes were fully reversed few days after HDBR termination, modifications could be attributed to decreased physiological loading and dehydration, resulting in reduced plasma, and blood volume.…”