Posterior capsule opacification

Abstract

Posterior capsule opacification (PCO) is the most common complication following primary cataract surgery. Advances in intraocular lens (IOL) designs that have reduced the amount of PCO following surgery have been made. The understanding of how the IOL design effects PCO has also advanced. Lenses that provide a mechanical barrier between it and the posterior lens capsule seem to inhibit PCO to a greater degree. Intracapsular rings are now being explored to test and enhance this barrier effect. Major advances in the elimination of lens epithelial cells at the time of surgery especially by pharmacologic means have also been made. An immunotoxin specific for human lens epithelial cells shows promise and is under latter phase clinical development.

Economic considerations related to choice of intraocular lens (IOL) and posterior capsule opacification frequency – a comparison of three different IOLs

“…Surgical technique, IOL design, and material and management of postoperative inflammation are some of the factors that are commonly addressed (Dewey 2006). Among surgical factors, cortical clean-up, size of the continuous curvilinear capsulorhexis (CCC) and 360-degree overlap of the CCC edge on the IOL optic have especially been stated to be of importance (Clark 2000). Other factors, like the expression of growth factors that promote migration of fibroblasts and lens epithelial cells, have been subject to intensive research, but have not yet been implicated in standard postoperative treatment (Wormstone et al 2009).…”

Growth inhibition of human lens epithelial cells by short hairpin RNA in transcription factor forkhead box E3 (FOXE3)

“…Posterior capsular opacification (PCO), also termed secondary cataract, is the most frequent complication of cataract surgery [1]. Advances in surgical techniques and intraocular lens materials and designs have reduced the rate of PCO.…”

Posteriore Kapselopazifikation nach Phakoemulsifikation bei Patienten mit rheumatoider Arthritis

“…Das charakteristische Merkmal der RA ist die mikrovaskuläre Verletzung mit Mononuklearzelleninfiltration in die Umgebung der kleinen Blutgefäße sowie das Vorhandensein aktivierter Lymphozyten, Makrophagen und anderer Zelltypen [23]. Entzündungszellen können bei der PCO eine Rolle spielen, vor allem bei Patienten mit einer signifikanten postoperativen Entzündung nach der Kataraktoperation [28]. Bei der Kataraktoperation wird die Blutkammerwasserschranke verletzt, vor allem nach extrakapsulärer Kataraktextraktion.…”

“…Eine Vorderkammerentzündung verursacht einen Blutkammerwasserschrankzusammenbruch. In diesem Fall entwickelt sich die PCO innerhalb des ersten postoperativen Monats und in den folgenden Monaten wird eine PCO-Regression ohne Besserung der Sehschärfe beobachtet [28].…”