Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge

Abstract

The square optic edge is the most important IOL design feature for PCO prevention. However, it should be present for 360 degrees around the IOL optic to provide an effective barrier effect.

Evaluation of a new single-piece 4% water content hydrophobic acrylic intraocular lens in the rabbit model

“…Rabbit and clinical studies found a better barrier effect against lens epithelial cell (LEC) migration with this design than with the earlier version (model 570H) with a smooth optic-haptic transition. 6,[21][22][23] The study IOL evaluated in our study has loops that are thinner close to the optic-haptic junctions, creating beveled barrier steps anteriorly and posteriorly to enhance prevention of cell migration/proliferation toward the visual axis. Even though PCO started at the level of the optic-haptic junctions in 3 of 5 eyes with the study IOL (versus 4 of 5 control eyes), significantly less PCO was observed in the study eyes at the end of the follow-up period.…”

“…Anesthesia, surgical preparation, and bilateral phacoemulsification with IOL implantation were performed as described in previous studies. [4][5][6]14 Briefly, a fornix-based conjunctival flap was fashioned. A corneoscleral incision was then made using a crescent blade, and the anterior chamber was entered with a 3.0 mm keratome.…”

“…The extent and severity of ACO and PCO were scored according to methods established in the laboratory. [4][5][6]14 After gross examination and photographs, the anterior segment of each eye was sectioned with the cuts oriented parallel to the axis passing through the optic-haptic junctions. This secured the entire IOL within the entire capsular bag and ensured that histopathological cuts would pass through the optic-haptic junctions.…”

Avaliação histopatológica da cápsula posterior associada ao implante de lente intraocular com superfície modificada com plasma de flúor e polietilenoglicol em coelhos

“…Diferentemente de Werner et al (2004) e Awasthi et al (2009), que sugerem que as diversas técnicas existentes, com diferentes graus de sucesso, tendem a diminuir a OCP, neste estudo, no M24, a utilização do tratamento à base de plasma de polietilenoglicol e flúor não promoveu a redução ou diminuição da OCP.…”

Incidence of posterior capsule opacification following the implantation of a foldable hydrophilic acrylic intraocular lens: a 4 year follow-up study

“…However, studies suggest that square-edged IOLs should completely encompass the 360 degrees around the IOL optic in order to provide an effective barrier (25) . Furthermore, another study has shown differences between brands of square-edged len- ses, and suggested that variations in their edge profiles may account for clinical differences in postoperative PCO rates (26) .…”