Posterior vitreous cortex hyalocytes visualization in asymmetric pigmented paravenous chorioretinal atrophy (PPCRA) using en face OCT

Fallon, Julia; Ahsanuddin, Sofia; Otero-Marquez, Oscar; Ríos, Hernán Andrés; Park, Michael M.; Chui, Toco Y. P.; Rosen, Richard B.

doi:10.1016/j.ajoc.2023.101846

Cited by 3 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 59 Finally, in a recent case report Fallon et al utilized a combination of OCTA and en face OCT to visualize the morphology of posterior hyalocites in a case of asymmetric PPCRA. 62 In more detail, hyalocites in the most advanced eye displayed a ramified appearance, suggestive of a “quiescent” stage, whereas those of the less advanced eye had an ameboid, “activated” shape. Their findings support the hypothesis that inflammation is a key factor in the pathophysiology of PPCRA.…”

Section: Multimodal Imaging In Ppcramentioning

confidence: 95%

Pigmented paravenous chorioretinal atrophy: Updated scenario

Antropoli,

Arrigo,

Pili

et al. 2023

European Journal of Ophthalmology

View full text Add to dashboard Cite

Pigmented paravenous chorioretinal atrophy (PPCRA) is an uncommon form of chorioretinal atrophy characterized by perivenous aggregations of pigment clumps associated with peripapillary and radial zones of retinal pigment epithelial atrophy that are distributed along the retinal veins. Most patients are asymptomatic, and evidence suggest that PPCRA is slowly progressing. Unless macular involvement is present, the majority of patients usually retain a normal visual function. Our ability to diagnose PPCRA has recently improved thanks to multimodal imaging, especially with the advent of ultra-widefield (UWF) imaging. Blood tests and functional and genetic testing can help with the correct differential diagnosis of pseudo-PPCRA or other disorders with similar characteristics. Although the cause of PPCRA is unknown, it is possible that it has a genetic basis. In this review we provide a summary of the multimodal imaging characteristics of PPCRA, and discuss its possible pathogenesis, based on the genes that have been associated with this disease.

show abstract

Section: Multimodal Imaging In Ppcramentioning

confidence: 95%

Pigmented paravenous chorioretinal atrophy: Updated scenario

Antropoli,

Arrigo,

Pili

et al. 2023

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

Upcoming invasive and noninvasive imaging modalities

Fallon,

Ahsanuddin,

Raval

et al. 2024

Retinal and Choroidal Vascular Diseases of the Eye

View full text Add to dashboard Cite

Ultrastructural investigation of the posterior hyaloid membrane in posterior vitreous detachment

Nixon,

Hayes,

Snead

et al. 2024

Eye

View full text Add to dashboard Cite

Background Separation of the posterior hyaloid membrane (PHM) from the retina in posterior vitreous detachment (PVD) is a fundamental, but poorly understood, process underlying vitreoretinal disorders including retinal detachment and macular hole. We performed electron microscopy studies of the PHM after PVD to investigate its ultrastructure, associated cellular structures and relationship to the internal limiting membrane (ILM). Methods Post-mortem human eyes were collected from recently deceased patients over 70 years of age. A posterior scleral button was trephined to identify PVD status, and the PHM and vitreous prepared for analysis with transmission and scanning electron microscopy. Results Twelve eyes from six patients were collected. Seven eyes had PVD; five eyes had attached vitreous. PHM was isolated from seven of seven eyes with PVD. The PHM in eyes with PVD is a laminar lacy sheet, distinct from the disorganised fibres of vitreous gel. Eyes without PVD had vitreous encased in internal limiting membrane which had separated en bloc from the retina. Cells embedded in the PHM (laminocytes) were identified in five of seven eyes with PVD, with strands stretching into the membrane. Conclusions PHM isolated from eyes with PVD is distinct from artefactual separation of the ILM from the retina during dissection. PHM is ultrastructurally distinct from vitreous gel and is a separate entity. The en face appearance of PHM is similar to that of ILM, suggesting that in PVD, PHM forms from separation of an inner layer of ILM. Laminocytes may play a role in the pathogenesis of vitreoretinal disease.

show abstract

Posterior vitreous cortex hyalocytes visualization in asymmetric pigmented paravenous chorioretinal atrophy (PPCRA) using en face OCT

Cited by 3 publications

References 37 publications

Pigmented paravenous chorioretinal atrophy: Updated scenario

Pigmented paravenous chorioretinal atrophy: Updated scenario

Upcoming invasive and noninvasive imaging modalities

Ultrastructural investigation of the posterior hyaloid membrane in posterior vitreous detachment

Contact Info

Product

Resources

About