Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants

Özgöz, Asuman; İçduygu, Fadime Mutlu; Yükseltürk, Ayşegül; Şamlı, Hale; Öztürk, Kuyaş Hekimler; Başkan, Zuhal; Tütüncü, İlknur

doi:10.17179/excli2020-2860

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Excessive estrogen production by adipose tissue is one of the most important molecular mechanisms linking obesity to breast cancer [ 24 ]. In postmenopause, the estrogen level in obese women tends to be 50–100% higher than in women with normal weight, which will lead to a greater risk of developing breast cancer [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Targeting Adiponectin in Breast Cancer

et al. 2022

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Obesity and breast cancer are two major health issues that could be categorized as sincere threats to human health. In the last few decades, the relationship between obesity and cancer has been well established and extensively investigated. There is strong evidence that overweight and obesity increase the risk of postmenopausal breast cancer, and adipokines are the central players in this relationship. Produced and secreted predominantly by white adipose tissue, adiponectin is a bioactive molecule that exhibits numerous protective effects and is considered the guardian angel of adipokine. In the obesity–cancer relationship, more and more evidence shows that adiponectin may prevent and protect individuals from developing breast cancer. Recently, several updates have been published on the implication of adiponectin in regulating tumor development, progression, and metastases. In this review, we provide an updated overview of the metabolic signaling linking adiponectin and breast cancer in all its stages. On the other hand, we critically summarize all the available promising candidates that may reactivate these pathways mainly by targeting adiponectin receptors. These molecules could be synthetic small molecules or plant-based proteins. Interestingly, the advances in genomics have made it possible to create peptide sequences that could specifically replace human adiponectin, activate its receptor, and mimic its function. Thus, the obvious anti-cancer activity of adiponectin on breast cancer should be better exploited, and adiponectin must be regarded as a serious biomarker that should be targeted in order to confront this threatening disease.

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Section: Introductionmentioning

confidence: 99%

Targeting Adiponectin in Breast Cancer

et al. 2022

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Genetic alterations in LEP and ADIPOQ genes and risk for breast cancer: a meta-analysis

Peng

Liu

et al. 2023

Front. Oncol.

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IntroductionBreast cancer has a strong genetic predisposition, and its genetic architecture is not fully understood thus far. In this study, we aimed to perform a meta-analysis to evaluate the association of genetic alterations in LEP and ADIPOQ genes, as well as their receptor-encoded genes with risk for breast cancer. MethodsOnly published studies conducted in humans and written in English were identified by searching PubMed, SCOPUS, CINAHIL and Embase from their inception to October 2022. Eligibility assessment and data collection were completed independently by two researchers. Statistical analyses were done using the STATA software. ResultsAfter literature search, 33 publications were eligible for inclusion. Overall, LEP gene rs7799039-G allele (odds ratio [OR]: 0.78, 95% confidence interval [CI]: 0.62 to 0.98) and ADIPOQ gene rs1501299-T allele (OR: 1.41, 95% CI: 1.06 to 1.88) were associated with the significant risk of breast cancer. In subgroup analyses, differences in menopausal status, obesity, race, study design, diagnosis of breast cancer, genotyping method and sample size might account for the divergent observations of individual studies. Circulating leptin levels were comparable across genotypes of LEP gene rs7799039, as well as that of LEPR gene rs1137101 (P>0.05). Begg’s funnel plots seemed symmetrical, with the exception of LEPR gene rs1137100 and ADIPOQ gene rs1501299. DiscussionTaken together, we found, in this meta-analysis, that LEP gene rs7799039 and ADIPOQ gene rs1501299 were two promising candidate loci in predisposition to breast cancer risk.

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Postmenopausal estrogen receptor positive breast cancer and obesity associated gene variants

Cited by 2 publications

References 38 publications

Targeting Adiponectin in Breast Cancer

Targeting Adiponectin in Breast Cancer

Genetic alterations in LEP and ADIPOQ genes and risk for breast cancer: a meta-analysis

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