Postmenopausal Hormone Replacement Therapy for Health Maintenance during Aging

Abstract

Several strategies have been proposed to prevent or reduce the rate of physiological decline in organ functions among aging postmenopausal women. These include increasing physical activity, improving nutrition, managing stress, and enhancing sleep quality. Although hormone replacement therapy (HRT) has been recommended, it remains a controversial topic, eliciting debate both in scientific circles and the public sphere. This book chapter aims to provide a comprehensive review of the current literature on the accelerated aging phenotype observed in postmenopausal women due to sex hormone deficiency. It will assess the efficacy and safety of HRT, offering a critical analysis of its benefits and risks. Moreover, the chapter will present a clinical perspective, suggesting practical advice for women approaching menopause. This guidance is intended for everyday clinical practice, aiming to support healthcare providers in offering informed, holistic care to this population.