Postmicturition Dribble Is Associated with Erectile Dysfunction in Middle-Aged and Older Men with Lower Urinary Tract Symptoms

Yang, Dae Yul; Ko, Kwang–Hoon; Lee, Seong Ho; Cho, Jin Seon; Lee, Sang-Kon; Shin, Tae Young; Lee, Won Ki

doi:10.5534/wjmh.180042

Cited by 9 publications

(22 citation statements)

References 28 publications

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“…It is possible to divide LUTS into storage, voiding and postmicturition symptoms [1]; however, almost all LUTS treatments are focused on storage and voiding symptoms, not on post-micturition symptoms [1,2], and even LUTS research does not focus on post-micturition symptoms. Physicians' and researchers' indifference to post-micturition symptoms may be attributable to the traditional belief that post-micturition symptoms may be a part of the aging process, have a low prevalence, and elicit less discomfort than other LUTS [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Effect of tadalafil 5 mg on post‐micturition dribble in men with lower urinary tract symptoms: a multicentre, double‐blind, randomized, placebo‐controlled trial

Yang

Jeong

et al. 2019

BJU International

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Objectives To compare the effects of taking tadalafil 5 mg and placebo once daily on post‐micturition dribble (PMD) in men with lower urinary tract symptoms (LUTS). Patients and Methods Our prospective, randomized, double‐blind, placebo‐controlled, multicentre trial enrolled 102 men with PMD and other LUTS. PMD was assessed using the Hallym Post‐Micturition Dribble Questionnaire (HPMDQ) and according to PMD volume. Over a 12‐week period, patients took either tadalafil 5 mg (n = 51) or placebo (n = 51) once daily and their HPMDQ and PMD volume results were evaluated. Adverse events (AEs) were also reported. Results Over the course of 12 weeks, total HPMDQscores and PMD volumes improved significantly more in the tadalafil group than in the placebo group (reduction of total HPMDQ score of ≥2 points in the tadalafil and placebo group in 68.8% and 31.9% of patients (P < 0.001) and decreased mean PMD volume in the tadalafil and placebo group at 0.48 mL and 0.22 mL, respectively (P = 0.046). Specifically, PMD frequency decreased and quality of life increased significantly more in the tadalafil group than in the placebo group (P = 0.029 and P < 0.001, respectively). Furthermore, 66.7% of the tadalafil group reported moderate and significant PMD improvement, whereas only 4.2% reported that tadalafil was ineffective. Treatment‐emergent AEs did not significantly differ between the groups (all P > 0.05), and no serious AEs were observed. Conclusion Taking tadalafil 5 mg once daily reduced PMD symptom severity and PMD volume in men with PMD, without inducing serious AEs, more effectively than placebo, suggesting that taking tadalafil 5 mg once daily may be an effective and well‐tolerated PMD treatment.

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Section: Introductionmentioning

confidence: 99%

“…Several epidemiological studies report that there may be a close association between PMD and erectile dysfunction (ED) . Recent experimental studies have also shown that corpus cavernosum structural changes may be related to the post‐micturition residual urine volume in the bulbous urethra .…”

Section: Introductionmentioning

confidence: 99%

Effect of tadalafil 5 mg on post‐micturition dribble in men with lower urinary tract symptoms: a multicentre, double‐blind, randomized, placebo‐controlled trial

Yang

Jeong

et al. 2019

BJU International

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“…Consultation on Incontinence-Short Form (ICIQ-SF) é uma ferramenta de grau a muito utilizada para avaliação da incontinência urinária possui uma questão que não se pontua no escore total do instrumento estando relacionada ao tipo de perda urinária e cujas alternativas de resposta incluem a perda por GPM (27) (28)(29)(30).…”

Section: Criado Para Superar Algumas Limitações Do Ipss O Internationunclassified

“…Encontramos em nossa pesquisa a disfunção erétil e a ejaculação precoce como preditores para o GPM. Um estudo envolvendo homens coreanos meia idade com sintomas urinários diagnosticados através do IPSS e HPMDQ e a disfunção erétil avaliada pelo IIEF-5 observaram a correlação entre disfunção erétil e GPM (29). Os autores concluíram que o GPM poderia ter um papel importante na associação entre sintomas urinários e disfunção erétil e a prevalência da desta última, estava estatisticamente relacionada com a gravidade do GPM (29).…”

Section: Epidemiologia Do Gpm Na Amostra Da Populaçãounclassified

“…Prevalência do GPM encontrada na população masculina em estudos epidemiológicos juntamente com entrevista sobre a história médica, frequência e comprometimento dos STUI. Os autores encontraram associação entre gravidade dos GPM e a insatisfação com a vida sexual com razão de chances de 1,72 para sintomas moderados e 2,20 para sintomas graves(91).No entanto, observa-se que a função erétil não refletiu diretamente sobre a satisfação com a vida sexual(29).Pesquisas em bases de dados sobre publicações nos últimos 20 anos acerca do GPM e sua epidemiologia, mostraram um número escasso de estudos sobre a ocorrência desta condição na população masculina brasileira(13,15). Por se tratar de pesquisas sobre os STUI, a prevalência deste sintoma foi investigada utilizando apenas o conceito da ICS sobre GPM em questionários estruturados, sem a exploração dos fatores de risco, associação com outras comorbidades e comprometimento da qualidade de vida.…”

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Validação do questionário de gotejamento pós-miccional - versão masculina (QGPM-M): um instrumento para avaliação e análise da prevalência do gotejamento pós-miccional em homens

Vasconcelos¹

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AGRADECIMENTOS A Deus, fonte de toda sabedoria, seja dada toda honra e glória por ter me sustentado e me ajudado a concluir esta trajetória. A meus pais, que não mediram esforços para impulsionar minha formação acadêmica, sempre me apoiando e ajudando nos momentos mais difíceis. À minha orientadora Profa. Dra. Raquel Aparecida Casarotto por acreditar em minha proposta e ter me aceitado como seu orientando, pela sua atenção, respeito, paciência e presteza nas orientações. Minha admiração e carinho por sua pessoa será infindável. Ao meu amigo-irmão Widmark de Farias Silva, não tenho palavras para agradecer sua hospitalidade durante minha estadia em São Paulo, seu companheirismo e amizade ao longo do doutorado. Á Profa. Dra. Marinalva Freire da Silva, pela valorosa contribuição na correção deste manuscrito, minha imensa gratidão. À CAPES pelo financiamento e apoio para o desenvolvimento do DINTER em Ciências da Reabilitação USP/UFPB. Ao corpo discente do DINTER, pelo companheirismo durante todo o curso, em especial a Juerila Moreira Barreto e Carina Carvalho Correia Coutinho e Lygia Stolt pela cumplicidade acadêmica, trocas de conhecimento e incentivos pessoais.

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Postmicturition dribble in men with no previous urogenital surgery: Systematic review and meta‐analysis of treatment modalities

Albakr,

El Ansari,

Mahdi

et al. 2023

Neurourology and Urodynamics

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IntroductionPostmicturition dribble (PMD) is common in males. Little is known about PMD etiology, but it is either secondary to urethral/prostatic surgery or primary (no previous surgery). Despite PMD's high prevalence, the effectiveness of its treatment modalities remains lacking.ObjectiveTo undertake a systematic review of the available treatments for primary PMD in adult males and meta‐analysis of their effectiveness.Materials and MethodsWe searched four electronic databases from inception to 2023 for original articles that evaluated PMD treatments in male adults without previous urethral/prostatic surgery (PROSPERO protocol CRD42023444591). Study quality and risk of bias were evaluated using established tools. We extracted a range of variables including treatment modality used and its effectiveness on PMD volume and patient complaint. Meta‐analysis was undertaken where feasible, and where this was not feasible, narrative synthesis was conducted.ResultsOut of 335 studies, four were included (four clinical trials, n = 344 patients). Two trials used physical/behavioral therapy (pelvic floor muscle exercises [PFMEs], urethral milking); the other two employed phosphodiesterase (PDE5) inhibitors (tadalafil, Udenafil). All studies were of good quality, but physical/behavioral therapy studies had some risk of bias. As the two physical/behavioral therapy studies used heterogenous outcome measures, narrative synthesis showed PMD volume improvement with PFMEs more than with urethral milking, both modalities were more effective than counseling, and in one study, PFMEs were effective in reducing PMD self‐reported complaint than counseling. Meta‐analyses of the two PDE5 inhibitors studies showed a large effect size with high heterogeneity for decreased PMD volume favoring PDE5 inhibitors over placebo (g = −0.86, 95% confidence interval [CI] −1.75; 0.02, p = 0.05; I2 = 88%); and a significant improvement equivalent to −1.06 points on the Hallym PMD Questionnaire score with no discernable heterogeneity (95% CI −1.65; −0.47, p = 0.0004; I2 = 0%), favoring PDE5 inhibitors compared to controls.ConclusionsPhysical/behavioral therapy and PDE5 inhibitors are effective primary PMD treatments. PMD management studies in males with no previous urethral/prostatic surgery are very scarce and lack the use of consistent/comparable outcome measures. Further studies addressing these deficiencies would benefit this very thin evidence base.

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Postmicturition Dribble Is Associated with Erectile Dysfunction in Middle-Aged and Older Men with Lower Urinary Tract Symptoms

Cited by 9 publications

References 28 publications

Effect of tadalafil 5 mg on post‐micturition dribble in men with lower urinary tract symptoms: a multicentre, double‐blind, randomized, placebo‐controlled trial

Effect of tadalafil 5 mg on post‐micturition dribble in men with lower urinary tract symptoms: a multicentre, double‐blind, randomized, placebo‐controlled trial

Validação do questionário de gotejamento pós-miccional - versão masculina (QGPM-M): um instrumento para avaliação e análise da prevalência do gotejamento pós-miccional em homens

Postmicturition dribble in men with no previous urogenital surgery: Systematic review and meta‐analysis of treatment modalities

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