Postmortem distribution of trazodone concentrations

McIntyre, Iain M.; Mallett, Phyllis; Stabley, Robert

doi:10.1016/j.forsciint.2015.04.009

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…The authors observed a minor degradation of trazodone in post-mortem blood samples stored at 4 • C and about a 20% decrease in samples stored up to eight months. The data collected by the authors demonstrated that trazodone was unlikely to show significant redistribution [43].…”

Section: Discussionmentioning

confidence: 93%

Forensic Aspects of a Fatal Intoxication Involving Acetaminophen, Citalopram and Trazodone: A Case Report

Mannocchi

Tittarelli

Pantano³

et al. 2022

Toxics

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We report the case of a young man, a former heroin addict, found dead at home by the Police Forces in an advanced state of decomposition. Numerous blisters and unpacked tablets of medications were found all over the bed and on the floor of the room. Multiple injuries to the face, left arm and neck of the deceased were noted. The latter damages were attributed to post-mortem dog bites, since no indications of a possible defense against the animal were observed. The autopsy findings were unremarkable. Toxicological investigations performed on peripheral blood and urine by gas chromatography-mass spectrometry (GC-MS) technique showed the presence of acetaminophen, citalopram and trazodone. Combined drug intoxication was proposed as the cause of death since acetaminophen and trazodone concentrations were comparable with the ones found in fatal cases. Moreover, citalopram concentration in peripheral blood was above the toxic range and in accordance with levels found in fatalities due to poly-drug intoxication.

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Section: Discussionmentioning

confidence: 93%

Forensic Aspects of a Fatal Intoxication Involving Acetaminophen, Citalopram and Trazodone: A Case Report

Mannocchi

Tittarelli

Pantano³

et al. 2022

Toxics

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“…In contrast, as shown in Table , pretreatment resulted in good recoveries. Additional standard solutions of 2.5, 5, and 7.5 μmol/L trazodone were selected according to a previously reported dose study …”

Section: Resultsmentioning

confidence: 99%

“…Additional standard solutions of 2.5, 5, and 7.5 μmol/L trazodone were selected according to a previously reported dose study. [4] 3.7 | The kinetic profile of CL The kinetic CL curve was obtained by stopping flow using 0.1 μmol/L trazodone, 300 μmol/L R6G, 500 μmol/L permanganate, and a peristaltic pump. The time constant of the CL analyser was set to 1 sec.…”

Section: Applicationsmentioning

confidence: 99%

“…[1] Many studies have determined the trazodone levels in pharmaceutical or biological samples. Trazodone assays based on spectrophotometric techniques, such as ion-pair formation, [2] gas chromatography (GC), [3] high-performance liquid chromatography (HPLC), [4,5] micellar liquid chromatography, [6] and high-performance thin-layer chromatography (HPTLC), [7] have been developed. Electrochemical analyses using cyclic voltammetry, [8,9] capillary electrophoresis, [10] and ionselective electrodes (ISEs) [11,12] have also been conducted.…”

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confidence: 99%

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Enhanced chemiluminescence for trazodone trace analysis based on acidic permanganate oxidation in concurrent presence of rhodamine 6G

et al. 2017

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A new sensitized chemiluminescence method by acidic permanganate oxidation was developed for the sensitive determination of trazodone. A fluorescent dye as used rhodamine 6G to increase a chemiluminescence intensity. Under optimum conditions, the liner range of the calibration curve was obtained for 1-5000 nmol/L. The limit of detection was calculated from 3σ of a blank was 0.23 nmol/L. The coexistent ions and substances had no interference with the chemiluminescence measurement. The chemiluminescence spectra were measured to elucidate a possible mechanism for the system. The present method was satisfactorily used in the determination of the drugs in pharmaceutical samples and animal serums.

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