Postnatal development: coordination of feeding, digestion, and metabolism

Henning, Susan J.

doi:10.1152/ajpgi.1981.241.3.g199

Cited by 420 publications

(517 citation statements)

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“…Glucocorticoids precociously induce activities of several of the enzymes in the intestines of immature animals [98][99][100][101], indicating that these hormones probably play a role in the developmental maturation of this pathway, as is the case for many other developmentally regulated pathways in this organ [102]. This may explain why dexamethasone increases plasma concentrations of ornithine, citrulline and arginine in pre-term infants [103].…”

Section: Intestinal Arginine Synthesismentioning

confidence: 99%

Arginine metabolism: nitric oxide and beyond

Morris

1998

Biochemical Journal

2,450

2,036

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Arginine is one of the most versatile amino acids in animal cells, serving as a precursor for the synthesis not only of proteins but also of nitric oxide, urea, polyamines, proline, glutamate, creatine and agmatine. Of the enzymes that catalyse rate-controlling steps in arginine synthesis and catabolism, argininosuccinate synthase, the two arginase isoenzymes, the three nitric oxide synthase isoenzymes and arginine decarboxylase have been recognized in recent years as key factors in regulating newly identified aspects of arginine metabolism. In particular, changes in the activities of argininosuccinate synthase, the arginases, the inducible isoenzyme of nitric oxide synthase and also cationic amino acid transporters play major roles in determining the metabolic fates of arginine in health and disease, and recent studies have identified

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Section: Intestinal Arginine Synthesismentioning

confidence: 99%

Arginine metabolism: nitric oxide and beyond

Morris

1998

Biochemical Journal

2,450

2,036

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“…Weaning is a critical but also inevitable stage in the postnatal growth and metabolism of mammals (Henning, 1981;Wang et al, 2008). Abrupt weaning is commonly associated with a period of low feed intake, decreased digestive capability, and increased occurrence of enteric diseases and diarrhea (Bruininx et al, 2001;Wijtten et al, 2011), generally leading to a net catabolic state (le Dividich and Sève, 2000).…”

Section: Introductionmentioning

confidence: 99%

Response to weaning and dietary l-glutamine supplementation: metabolomic analysis in piglets by gas chromatography/mass spectrometry

Xiao

Hong

et al. 2012

J. Zhejiang Univ. Sci. B

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A novel metabolomic method based on gas chromatography/mass spectrometry (GC-MS) was applied to determine the metabolites in the serum of piglets in response to weaning and dietary L-glutamine (Gln) supplementation. Thirty-six 21-d-old piglets were randomly assigned into three groups. One group continued to suckle from the sows (suckling group), whereas the other two groups were weaned and their diets were supplemented with 1% (w/w) Gln or isonitrogenous L-alanine, respectively, representing Gln group or control group. Serum samples were collected to characterize metabolites after a 7-d treatment. Results showed that twenty metabolites were down-regulated significantly (P<0.05) in control piglets compared with suckling ones. These data demonstrated that early weaning causes a wide range of metabolic changes across arginine and proline metabolism, aminosugar and nucleotide metabolism, galactose metabolism, glycerophospholipid metabolism, biosynthesis of unsaturated fatty acid, and fatty acid metabolism. Dietary Gln supplementation increased the levels of creatinine, D-xylose, 2-hydroxybutyric acid, palmitelaidic acid, and α-L-galactofuranose (P<0.05) in early weaned piglets, and were involved in the arginine and proline metabolism, carbohydrate metabolism, and fatty acid metabolism. A leave-one-out cross-validation of random forest analysis indicated that creatinine was the most important metabolite among the three groups. Notably, the concentration of creatinine in control piglets was decreased (P=0.00001) compared to the suckling piglets, and increased (P=0.0003) in Gln-supplemented piglets. A correlation network for weaned and suckling piglets revealed that early weaning changed the metabolic pathways, leading to the abnormality of carbohydrate metabolism, amino acid metabolism, and lipid metabolism, which could be partially improved by dietary Gln supplementation. These findings provide fresh insight into the complex metabolic changes in response to early weaning and dietary Gln supplementation in piglets.

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“…Many hormonal and metabolic factors participate to the regulation of metabolism during this period and some regulatory mechanisms even anticipate the changes in the nutritional environment (Greengard, 1971 ;Henning, 1981). We have chosen to focus on the role of insulin and glucagon since, in adult mammals, the pattern of secretion of insulin and glucagon play a fundamental role in the adaptation of glucose and lipid metabolism to changing nutritional conditions.…”

Section: Introductionmentioning

confidence: 99%