Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex

Graterón, L.; Cebada‐Sánchez, Sandra; Marcos, Pilar; Mohedano-Moriano, Alicia; Insausti, A.M.; Muñoz, Mónica; Arroyo-Jiménez, M.M.; Martı́nez-Marcos, Alino; Artacho‐Pérula, Emilio; Blaizot, Xavier; Insausti, Ricardo

doi:10.1016/j.jchemneu.2003.09.005

Cited by 56 publications

(49 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The late postnatal maturation of PVB-IR neurons in several brain regions supports this hypothesis (Berdel and Morys 2000;Lopez-Tellez et al 2004;Reynolds and Beasley 2001). Notably, the human ECx follows a protracted postnatal development, and ECx PVB-IR neurons are not detectable until the 5th month after birth (Grateron et al 2002(Grateron et al , 2003. Finally, the possibility that cell death might be a contributing factor cannot be excluded.…”

Section: Experimental Design Considerationsmentioning

confidence: 94%

Parvalbumin Neurons in the Entorhinal Cortex of Subjects Diagnosed With Bipolar Disorder or Schizophrenia

Pantazopoulos¹,

Lange²,

Baldessarini³

et al. 2007

Biological Psychiatry

View full text Add to dashboard Cite

show abstract

Section: Experimental Design Considerationsmentioning

confidence: 94%

Parvalbumin Neurons in the Entorhinal Cortex of Subjects Diagnosed With Bipolar Disorder or Schizophrenia

Pantazopoulos¹,

Lange²,

Baldessarini³

et al. 2007

Biological Psychiatry

View full text Add to dashboard Cite

show abstract

“…In particular, the superficial layers (layers I-III) are not clearly differentiated, suggesting that the entorhinal neurons that originate the main projections to the dentate gyrus and the hippocampus (layer II and III neurons) are not yet fully mature. Neurochemical findings also suggest protracted maturation of entorhinal neurons (see below) [Grateron et al, 2003].…”

Section: Connectivitymentioning

confidence: 96%

“…Indeed, all available data indicate that there is significant postnatal maturation throughout the hippocampal formation [Giedd et al, 1996;Grateron et al, 2002Grateron et al, , 2003Saitoh et al, 2001]. In the monkey, studies by Duffy and Rakic [1983] and Seress [1992] indicate that the dendritic arborization of the granule cells, in the molecular layer of the dentate gyrus, matures during the first 6 months of life.…”

Section: Volumetric Changes and Dendritic Growthmentioning

confidence: 99%

“…Although the structures of the primate hippocampal formation are easily recognizable at birth ( fig. 2 ) Arnold and Trojanowski, 1996], they undergo substantial postnatal maturation throughout infant and juvenile life [this article; Giedd et al, 1996;Grateron et al, 2002Grateron et al, , 2003Saitoh et al, 2001]. It is reasonable to predict, therefore, that during this critical postnatal maturational period these structures might be particularly sensitive to factors capable of altering the expression of specific genes, thus affecting normal development.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Postnatal Development of the Primate Hippocampal Formation

Lavenex

Amaral

2006

Dev Neurosci

View full text Add to dashboard Cite

The hippocampal formation is a multicomponent region of the medial temporal lobe preferentially involved in declarative and relational memory processing. Behavioral studies have suggested a protracted functional maturation of these structures in primates, and postnatal developmental abnormalities in the hippocampal formation are thought to contribute to neurodevelopmental disorders, such as autism, schizophrenia, epilepsy and Down syndrome. Despite all that we know about the functional organization of the adult hippocampal formation, notably absent is a systematic study of its postnatal maturation in primates. In this article, we review current knowledge of the structural development of the primate hippocampal formation and present new data on its postnatal neuroanatomical development. We summarize what is known about the neurobiological processes, such as the addition of new neurons, the establishment and elaboration of connectivity, and the neurochemical changes, that underlie the structural development and functional maturation of the primate hippocampal formation. We conclude that there is yet insufficient information to identify distinct developmental windows during which different hippocampal regions undergo specific maturational processes. For this reason, it is currently impossible to determine the ages at which specific hippocampal circuits become structurally mature and potentially capable of supporting defined, age-specific functional processes. Together with work in rodents, systematic studies of the structural development and functional maturation of the monkey hippocampal formation will be necessary to gain insight not only into the types of information processing that it subserves, but also into the specific maturational processes that might be affected in human neurodevelopmental disorders.

show abstract

“…The levels of the inhibitory neurotransmitter GABA profoundly influence inhibitory neuron axon growth and synapse formation during brain postnatal development, and alterations in GAD67, the main enzyme producing GABA, can have profound effects on the proper development of inhibitory circuits (reviewed in 88). Among all inhibitory neurons in the cortex, and across species, the last to mature are the PV + inhibitory neurons (74,82,196). In rodents, the maturational process of these neurons starts at the end of the first postnatal week (47, 51, 175).…”

Section: Nox2 In Schizophreniamentioning

confidence: 99%

How Nox2-Containing NADPH Oxidase Affects Cortical Circuits in the NMDA Receptor Antagonist Model of Schizophrenia

Wang

Pinto-Duarte

Sejnowski

et al. 2013

Antioxidants & Redox Signaling

View full text Add to dashboard Cite

Significance: Schizophrenia is a complex neuropsychiatric disorder affecting around 1% of the population worldwide. Its mode of inheritance suggests a multigenic neurodevelopmental disorder with symptoms appearing during late adolescence/early adulthood, with its onset strongly influenced by environmental stimuli. Many neurotransmitter systems, including dopamine, glutamate, and gamma-aminobutyric acid, show alterations in affected individuals, and the behavioral and physiological characteristics of the disease can be mimicked by drugs that produce blockade of N-methyl-d-aspartate glutamate receptors (NMDARs). Recent Advances: Mounting evidence suggests that drugs that block NMDARs specifically impair the inhibitory capacity of parvalbumin-expressing (PV+) fast-spiking neurons in adult and developing rodents, and alterations in these inhibitory neurons is one of the most consistent findings in the schizophrenic postmortem brain. Disruption of the inhibitory capacity of PV+ inhibitory neurons will alter the functional balance between excitation and inhibition in prefrontal cortical circuits producing impairment of working memory processes such as those observed in schizophrenia. Critical Issues: Mechanistically, the effect of NMDAR antagonists can be attributed to the activation of the Nox2-dependent reduced form of nicotinamide adenine dinucleotide phosphate oxidase pathway in cortical neurons, which is consistent with the emerging role of oxidative stress in the pathogenesis of mental disorders, specifically schizophrenia. Here we review the mechanisms by which NMDAR antagonists produce lasting impairment of the cortical PV+ neuronal system and the roles played by Nox2-dependent oxidative stress mechanisms. Future Directions: The discovery of the pathways by which oxidative stress leads to unbalanced excitation and inhibition in cortical neural circuits opens a new perspective toward understanding the biological underpinnings of schizophrenia.

show abstract

Postnatal development of calcium-binding proteins immunoreactivity (parvalbumin, calbindin, calretinin) in the human entorhinal cortex

Cited by 56 publications

References 19 publications

Parvalbumin Neurons in the Entorhinal Cortex of Subjects Diagnosed With Bipolar Disorder or Schizophrenia

Parvalbumin Neurons in the Entorhinal Cortex of Subjects Diagnosed With Bipolar Disorder or Schizophrenia

Postnatal Development of the Primate Hippocampal Formation

How Nox2-Containing NADPH Oxidase Affects Cortical Circuits in the NMDA Receptor Antagonist Model of Schizophrenia

Contact Info

Product

Resources

About