Postnatal development of fiber types in normal and dystrophic skeletal muscle of the chick

Ashmore, C. R.; Doerr, L.

doi:10.1016/0014-4886(71)90144-0

Cited by 170 publications

(58 citation statements)

References 20 publications

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“…Six serial cross-sections per bird were prepared to evaluate the size, the typology and the lipid content of myofibres. Fibre types were determined on the basis of their ATPase activity after preincubation at pH 4.10 and 10.50 [10] and their succinate dehydrogenase (SDH) activity [11]. Myofibres were classified as type βR and α according to the terminology of Ashmore and Doerr [11].…”

Section: Histological Analysismentioning

confidence: 99%

“…Fibre types were determined on the basis of their ATPase activity after preincubation at pH 4.10 and 10.50 [10] and their succinate dehydrogenase (SDH) activity [11]. Myofibres were classified as type βR and α according to the terminology of Ashmore and Doerr [11]. Slow-twitch fibres (type βR) were identified as being stable after acid preincubation and labile after alkaline preincubation, while fast-twitch fibres (type α) were labile after acid preincubation and stable after alkaline preincubation.…”

Section: Histological Analysismentioning

confidence: 99%

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Effect of genotype and overfeeding on lipid deposition in myofibres and intramuscular adipocytes of breast and thigh muscles of ducks

Chartrin¹,

Schiavone

Bernadet³

et al. 2005

Reprod. Nutr. Dev.

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-We conducted a study to evaluate the effects of genotype (Muscovy, Pekin and their crossbred, hinny and mule) and overfeeding (14 days from 12 weeks of age) on lipid deposition in myofibres and intramuscular adipocytes of breast and thigh muscles of ducks. Birds of the four genotypes were also reared contemporaneously with a growing diet distributed ad libitum. Muscle samples (Pectoralis major and Sartorius) were collected at 14 weeks of age on 8 ducks per treatment. The muscle fibre typing, the total lipid and triglyceride contents in myofibres and the relative surface occupied by adipocytes on the cross-sectional area of the muscles were determined by histological and image analysis. Overfeeding induced a marked increase of body weight but had no significant effect on the muscle weight, the cross-sectional area (CSA) of myofibres and the muscle typology. In muscles, overfeeding induced a large accumulation of lipids, mainly in adipocytes whose relative surface increased 1.5 fold in P. major and 2.1 fold in Sartorius and an increase in triglyceride content of fast twitch oxydo-glycolytic and glycolytic fibres in P. major only (+ 37 and + 16% respectively). Genotype had no significant effect on the muscle typology. By comparison with the other genotypes, Muscovy ducks exhibited the highest body weight, the highest muscle weight which could partly be explained by the highest fibre CSA and the lowest intramuscular fat content in adipocytes and myofibres (only fast twitch oxydo-glycolytic fibres in P. major). We observed the reverse situation for the Pekin ducks. The crossbred ducks always presented intermediate values except for body weight. lipids / myofibres / adipocytes / muscles / ducks

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Section: Histological Analysismentioning

confidence: 99%

Section: Histological Analysismentioning

confidence: 99%

Effect of genotype and overfeeding on lipid deposition in myofibres and intramuscular adipocytes of breast and thigh muscles of ducks

Chartrin¹,

Schiavone

Bernadet³

et al. 2005

Reprod. Nutr. Dev.

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“…A direct correlation was proved between the histochemical mATPase staining and the myosin heavy chain (MHC) composition of muscle fibres (Gauthier and Lowey, 1979;Staron and Pette, 1986;Staron, 1991 ). A sequential appearance of various MHC isoforms was demonstrated from fetal to adult animal stages (Whalen et al, 1981;Gauthier, 1987;Harris et al, 1989 (Ashmore et al, 1972;Rehfeldt et al, 1987), rat (Maltin et al, 1985;Tamaki, 1985), mouse (Rehfeldt et al, 1987) and chick muscles (Ashmore and Doerr, 1971 ).…”

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confidence: 94%

Fibre type differentiation during postnatal development of miniature pig skeletal muscles

Horák

1995

Reprod. Nutr. Dev.

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Summary ― Histochemical differentiation of 12 skeletal muscles with a different fibre type composition was studied in miniature pigs from 80 d of gestation to 1 year of age. Two fetal myofibre types were distinguished at 100 d of gestation by the mATPase reaction after acid preincubation. The staining for oxidative enzyme activities showed no conspicuous differences between fibres up to the 6th day after birth. Starting from this age it was possible to distinguish 3 fibre categories: SO (slow-twitch oxidative); FOG (fast-twitch oxidative-glycolytic); and FG (fast-twitch glycolytic). A characteristic cluster distribution of the 3 fibre types was observed in all studied muscles with the exception of the masseter muscle which consisted only of the type SO and FOG fibres with a mosaic arrangement. The

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“…The rasH2 mouse might be a useful model for exploring this diversity of phenotypes in muscular degeneration based on the muscle fiber type, since susceptibility to myopathy was different among muscles or muscle fiber types in the rasH2 mouse. Only type II fiber is also known to be affected in the chicken muscular dystrophy model [1,23,33]. But, a mouse model is thought to have an advantage in the view of ease of maintain and handle.…”

Section: Fig 2 Histochemical Analysis Of Cryosections Of Skeletal Mmentioning

confidence: 99%

Histopathological Characterization of the Skeletal Myopathy in rasH2 Mice Carrying Human Prototype c-Ha-ras Gene

Tsuchiya¹,

Okada²,

Sakairi³

et al. 2005

The Journal of Veterinary Medical Science

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ABSTRACT. A skeletal myopathy is found in approximately 100% of rasH2 mice. To confirm detailed features of the rasH2 skeletal myopathy, the biceps femoris, diaphragm, triceps brachii, gastrocnemial (types I and II fiber-mixed muscles) and soleus muscle (type I fiberdominant muscle) obtained from male rasH2 and non-transgenic littermates aged 10-13 and 34 weeks were examined. Variations in the muscle fiber size, early-scattered degeneration/necrosis and regeneration of muscle fibers were detected in 10-13-week-old rasH2 mice. The severity of the above muscular lesions was more prominent in older rasH2 mice. These lesions were noted in the type II myofiber dominant muscles (biceps femoris, triceps brachii and gastrocnemial). NADH-TR stain clearly demonstrated a disorganized intermyofibrillar network and necrotic change in muscle fibers. No specific morphological changes, like rod structure or tubular aggregation seen in some types of myopathy, were noted in Gomori trichrome and NADH-TR stains in the rasH2 mouse like in many types of muscular dystrophy. Electronmicroscopically, occasional muscle fiber degeneration/regeneration, invaded phagocytic cells, indistinct Z-band suggesting excessive contraction and dilatation of the sarcoplasmic reticulum were observed. In summary, the skeletal myopathy occurring in rasH2 mice is consistent with muscular dystrophy characterized morphologically by progressive degeneration and regeneration of myofibers. The myopathy is confined to the type II myofiber predominant muscles and is not associated with any pathognomonic lesions. These characteristics will provide us with a useful model for research in muscular dystrophy of diverse myofibers. KEY WORDS: histopathology, rasH2 mouse, skeletal myopathy.

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Postnatal development of fiber types in normal and dystrophic skeletal muscle of the chick

Cited by 170 publications

References 20 publications

Effect of genotype and overfeeding on lipid deposition in myofibres and intramuscular adipocytes of breast and thigh muscles of ducks

Effect of genotype and overfeeding on lipid deposition in myofibres and intramuscular adipocytes of breast and thigh muscles of ducks

Fibre type differentiation during postnatal development of miniature pig skeletal muscles

Histopathological Characterization of the Skeletal Myopathy in rasH2 Mice Carrying Human Prototype c-Ha-ras Gene

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