Postnatal Glucose Homeostasis in Late-Preterm and Term Infants

Adamkin, David H.

doi:10.1542/peds.2010-3851

Cited by 615 publications

(323 citation statements)

References 25 publications

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“…Jaundice was defined by neonatal hyperbilirubinemia requiring phototherapy with at least one laboratory report of a bilirubin level exceeding 15 mg/dL. Neonatal hypoglycemia was diagnosed by pediatricians, which was defined as plasma glucose ≤45 mg/dL 12 h after birth21. The study was reviewed and approved by the research ethics committee of the National Taiwan University Hospital titled as ‘Applied One‐step Screening for Gestational Diabetes in Taiwan: Effect on Prevalence and Perinatal Outcome.’ Written informed consent was obtained from each patient before enrolment.…”

Section: Methodsmentioning

confidence: 99%

Diagnosis of more gestational diabetes lead to better pregnancy outcomes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria

Nien

Kuo

et al. 2015

J of Diabetes Invest

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Aims/IntroductionThe International Association of the Diabetes and Pregnancy Study Group (IADPSG) criteria for gestational diabetes are associated with increased prevalence. However, it remains unknown if intervention for more women with gestational diabetes mellitus by the IADPSG criteria results in better pregnancy outcomes than adopting the Carpenter and Coustan (C&C) criteria in Asian populations.Materials and MethodsThis was a retrospective cohort study. A total of 1,840 women, 952 subjects by the IADPSG criteria and 888 subjects by the C&C criteria, who delivered singletons in 2011 in a single tertiary center, were included in the study. The same therapeutic interventions were offered to women with gestational diabetes mellitus by the two criteria. Maternal and neonatal outcomes were evaluated.ResultsAdopting the IADPSG criteria increased the prevalence of gestational diabetes mellitus diagnosis to 13.44%, compared with 2.59% by the C&C criteria. The diagnosis was made 3 weeks earlier by the IADPSG criteria (27 vs 30.5 weeks, P < 0.0001). Adopting the IADPSG criteria was associated with reduced risk of primary cesarean section (adjusted odds ratio 0.79, 95% confidence interval 0.63–0.998, P < 0.05) and having any one of the adverse fetal outcomes (adjusted odds ratio 0.79, 95% confidence interval 0.64–0.998, P < 0.05), including birthweight >90th percentile, jaundice, admission to neonatal intensive care unit, birth trauma, neonatal hypoglycemia and fetal death.ConclusionsAdopting the IADPSG criteria is associated with improved pregnancy outcomes, at the expense of increased prevalence of gestational diabetes mellitus diagnosis.

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Section: Methodsmentioning

confidence: 99%

Diagnosis of more gestational diabetes lead to better pregnancy outcomes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria

Nien

Kuo

et al. 2015

J of Diabetes Invest

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“…According to the American Academy Pediatric, neonatal hypoglycaemia is defined as a venous blood glucose lower than or equal to 2.5 mmol/l (0.45 g/l) [1].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)

Ouattara¹,

Cissé²,

Koffi³

et al. 2017

OJPed

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The purpose of this study is to determine the prevalence, the characteristics of hypoglycaemia in the newborn admitted to emergency departments of teaching Hospital of Treichville, Abidjan and to evaluate the relevance of capillary blood glucose in this diagnosis. Patients and Methods: This prospective cross-sectional study was held from 01 February to 25 June 2017 in the Pediatric Emergency Department. It involved 201 newborns under 24 hours of age who consulted in pediatric emergency for any reason. Data were collected from parent direct interviews, analysis of the follow-up record, physical examination of the newborn, results of glucose level in the capillary blood at heel and in venous blood. On dry tube and gray tube (containing sodium fluoride and potassium oxalate), the blood glucose on the latter tube constituting the reference blood glucose, with neonatal hypoglycaemia defined by a venous blood glucose less than or equal to 2.5 mmol/l (0.45 g/l). The statistical tests used were the frequency comparison, the Chi Square, the Fisher Test with a significance threshold p < 0.05 or the Odds-ratio with a confidence interval of 95% and a significance threshold of 5%, but also with the correlation coefficient. Results: Newborns of less than 3 hours of life (70.6%) were the most represented with a male predominance (sex ratio = 2.9). The reasons for consultation were dominated by neurological disorders (36.5%), prematurity (31.8%), and fever (22.2%). The average time to complete the blood glucose test was less than one hour after the sampling in 6.5% of the cases. The mean blood glucose was 0.59 g/l (3.28 mmol/l) with extremes ranging from 0.15 to 1.8 g/l (0.83 mmol/l to 10 mmol/l). The prevalence of hypoglycemia by the instantaneous glycemic method was 15.9%. On tube containing sodium fluoride and potassium oxalate, it was 20.4%, while the prevalence of red blood cell hypoglycemia was 38.1%. A good correlation was found between capillary glycemia and gray tube with r = 0.97. Signs associated with hypoglycemia were predominantly male (p < 0.05), prematurity (p < 0.05). As for cerebral suffering, it had proved to be a protective factor (Fisher: 0.002). The mortality rate was 2.5%. Hypoglycemia was not found. Conclusion: Hypoglycaemia is relatively common in our working setting, particularly in premature infants. However, it should be carefully sought in any newborn admitted to emergency regardless of the reason for admission. The use of capillary blood glucose proves to be a good alternative because it allows a fast management.

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“…However, the limits of normal plasma glucose defining neonatal hypoglycemia in infants are arbitrary. Neonatal glucose concentrations may decrease after birth, to as low as 30 mg/dL during the first 1-2 hours after birth, and then increase to higher and relatively more stable concentrations, generally above 45 mg/dL by 12 hours after birth [65,66]. Later, it will gradually rise to adult levels.…”

Section: Maintenance Of Optimal Pre-pregnancy Bodyweight: the Key Promentioning

confidence: 99%

Principle of Management of Type 2 Diabetes: From Clinical, Public Health and Research Perspectives

Bhattarai¹

2018

Diabetes and Its Complications

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Apart from stopping smoking, controlling hypertension and using statin, losing possible excess bodyweight and regular physical activity and exercise are the cornerstones in diabetes management. There is often need of controlling blood glucose immediately. Approach of 'dynamic dose management of medications likely to cause hypoglycemia' helps to control high blood glucose immediately as and when required with sulfonylurea or insulin and to taper off their dose later. Anti-hyperglycemic medications which are unlikely to cause hypoglycemia are continued to control hyperglycemia. The diagnosis of gestational diabetes usually made at 24-28 weeks is applicable for clinical management of mother and child and for possible prevention of diabetes later in the mother. From the public health perspectives, however, protection of the susceptible in utero population from maternal malnutrition or clinical or subclinical hyperglycemia right from the time of conception itself also needs to be considered to control the diabetes epidemic at the population level. Campaigns and programmes for maintenance of optimal pre-pregnancy body weight as per the recommended body mass index of the respective populations along with regular physical activity and exercise during pregnancy are the essential measures available at hand to prevent the possibility of maternal hyperglycemia right from the early pregnancy.

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Postnatal Glucose Homeostasis in Late-Preterm and Term Infants

Cited by 615 publications

References 25 publications

Diagnosis of more gestational diabetes lead to better pregnancy outcomes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria

Diagnosis of more gestational diabetes lead to better pregnancy outcomes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)

Principle of Management of Type 2 Diabetes: From Clinical, Public Health and Research Perspectives

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Postnatal Glucose Homeostasis in Late-Preterm and Term Infants

Cited by 615 publications

References 25 publications

Diagnosis of more gestational diabetes lead to better pregnancy outcomes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria

Diagnosis of more gestational diabetes lead to better pregnancy outcomes: Comparing the International Association of the Diabetes and Pregnancy Study Group criteria, and the Carpenter and Coustan criteria

Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-C&#244;te d’Ivoire)

Principle of Management of Type 2 Diabetes: From Clinical, Public Health and Research Perspectives

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Clinical and Epidemiological Features and Management of Neonatal Hypoglycemia at the University Teaching Hospital of Treichville (Abidjan-Côte d’Ivoire)