Postoperative Infectious Complications are Associated with Adverse Oncologic Outcomes in Esophageal Cancer Patients Undergoing Preoperative Chemotherapy

Abstract

The incidence of postoperative infectious complications, in particular pulmonary infection, is associated with unfavorable prognosis in patients with esophageal cancer undergoing preoperative chemotherapy.

Retracted: Long‐term outcomes of 530 esophageal squamous cell carcinoma patients with minimally invasive Ivor Lewis esophagectomy

“…These results indicate that early diagnosis, prompt treatment, and careful postoperative management are important factors to improve OS and DFS. 24,25 RLN metastasis was frequent in esophageal cancer patients and was associated with poor survival and the removal of RLN lymph nodes could improve OS and DFS in ESCC patients, [26][27][28] which was in accordance with our results. Thus, RLN lymphadenectomy was 29 specialized adjuvant therapy for ESCC needs to be investigated.…”

“…Two of three independent prognosis factors were tumor‐related (pTNM stage and tumor length), one was surgeon‐related. These results indicate that early diagnosis, prompt treatment, and careful postoperative management are important factors to improve OS and DFS …”

Does postoperative morbidity worsen the oncological outcome after radical surgery for gastrointestinal cancers? A systematic review of the literature

“…Similarly, three independent single institutes in high‐volume centers of Japan have shown that pneumonia has a negative impact on OS after esophagectomy. The incidence of postoperative infectious complications and, in particular, pulmonary infections, is associated with unfavorable prognosis in patients with esophageal cancer undergoing preoperative chemotherapy 1, 2, 33…”

“…Albeit recent advancements in surgical techniques and perioperative care, the postoperative morbidity rate is as high as approximately 40% after esophageal cancer surgery,1, 2 and 20–30% after both gastric cancer surgery3, 4, 5 and colorectal surgery 6, 7, 8. Various reports have shown that such postoperative complications frequently reduce the overall survival (OS) as well as cancer‐specific survival after major surgery for cancer 9.…”

Sepsis Increases Perioperative Metastases in a Murine Model

“…Clinical studies in cancer patients have confirmed an association between perioperative factors such as hypothermia 37 , blood loss 38,39 , and postoperative infections 40,41 , and increased cancer recurrence and reduced cancer-specific survival following cancer surgery.…”