Postoperative Joint Replacement Complications in Swedish Patients With a Family History of Venous Thromboembolism

Zöller, Bengt; Svensson, Peter; Sundquist, Jan; Sundquist, Kristina; Pirouzifard, Mirnabi

doi:10.1001/jamanetworkopen.2018.1924

Cited by 9 publications

(8 citation statements)

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“…The Swedish national registers used for data extraction were: Swedish Multigeneration Register, containing data on familial relationships and index persons born in 1932 or later; National Patient Register, giving all hospital discharge diagnoses from 1964 to 2015, with nationwide coverage from 1987 and hospital outpatient diagnoses from 2001 to 2015; Total Population Register, containing data on date of death, marital status, education, and migration with high degree of coverage; and the Swedish Cause of Death Register . [13][14][15][16][17][18] The databases were linked, as previously described, [19][20][21] through the personal identity number, which is seldom incorrect. 18 Up to January 2008, an estimated 75 638 (0.56%) individuals had changed their personal identity number compared with the estimated 13 500 000 personal identity numbers in Sweden from 1969 to 31 December 2007.…”

Section: General Description Of Swedish Registersmentioning

confidence: 99%

Familial aggregation of multimorbidity in Sweden: national explorative family study

Zöller

Pirouzifard

Holmquist

et al. 2023

bmjmed

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ObjectivesTo examine whether multimorbidity aggregates in families in Sweden.DesignNational explorative family study.SettingSwedish Multigeneration Register linked to the National Patient Register, 1997-2015. Multimorbidity was assessed with a modified counting method of 45 chronic non-communicable diseases according to ICD-10 (international classification of diseases, 10th revision) diagnoses.Participants2 694 442 Swedish born individuals (48.73% women) who could be linked to their Swedish born first, second, and third degree relatives. Twins were defined as full siblings born on the same date.Main outcome measuresMultimorbidity was defined as two or more non-communicable diseases. Familial associations for one, two, three, four, and five or more non-communicable diseases were assessed to examine risks depending on the number of non-communicable diseases. Familial adjusted odds ratios for multimorbidity were calculated for individuals with a diagnosis of multimorbidity compared with relatives of individuals unaffected by multimorbidity (reference). An initial principal component decomposition followed by a factor analysis with a principal factor method and an oblique promax rotation was used on the correlation matrix of tetrachoric correlations between 45 diagnoses in patients to identify disease clusters.ResultsThe odds ratios for multimorbidity were 2.89 in twins (95% confidence interval 2.56 to 3.25), 1.81 in full siblings (1.78 to 1.84), 1.26 in half siblings (1.24 to 1.28), and 1.13 in cousins (1.12 to 1.14) of relatives with a diagnosis of multimorbidity. The odds ratios for multimorbidity increased with the number of diseases in relatives. For example, among twins, the odds ratios for multimorbidity were 1.73, 2.84, 4.09, 4.63, and 6.66 for an increasing number of diseases in relatives, from one to five or more, respectively. Odds ratios were highest at younger ages: in twins, the odds ratio was 3.22 for those aged ≤20 years, 3.14 for those aged 21-30 years, and 2.29 for those aged >30 years at the end of follow-up. Nine disease clusters (factor clusters 1-9) were identified, of which seven aggregated in families. The first three disease clusters in the principal component decomposition were cardiometabolic disease (factor 1), mental health disorders (factor 2), and disorders of the digestive system (factor 3). Odds ratios for multimorbidity in twins, siblings, half siblings, and cousins for the factor 1 cluster were 2.79 (95% confidence interval 0.97 to 8.06), 2.62 (2.39 to 2.88), 1.52 (1.34 to 1.73), and 1.31 (1.23 to 1.39), and for the factor 2 cluster, 5.79 (4.48 to 7.48) 3.24 (3.13 to 3.36), 1.51 (1.45 to 1.57), and 1.37 (1.341.40).ConclusionsThe results of this explorative family study indicated that multimorbidity aggregated in Swedish families. The findings suggest that map clusters of diseases should be used for the genetic study of common diseases to show new genetic patterns of non-communicable diseases.

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Section: General Description Of Swedish Registersmentioning

confidence: 99%

Familial aggregation of multimorbidity in Sweden: national explorative family study

Zöller

Pirouzifard

Holmquist

et al. 2023

bmjmed

Self Cite

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“…For instance, a recent study has shown that family history of VTE affects the risk of both VTE and major bleeding following hip and knee replacement surgical procedures. 9 It could therefore be worthwhile to determine the value of the new GRS for prediction of both VTE and bleeding.…”

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confidence: 99%

Genetics of venous thromboembolism revised

Zöller¹

2019

Blood

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“…Activation of extremity and pulmonary thrombogenesis, by way of thromboplastin exposure, has been hypothesized to contribute to DVT and PE rates following TJA, however intraoperative steps have been taken to mitigate this process 682,689 . Manifestation of symptomatic PE is a complex, multifactorial process, with multiple pathophysiological pathways likely coexisting in genetically susceptible patients, however propagation of an extremity thrombus does not appear to consistently contribute to the burden of arthroplasty-related PE disease 690-692 .…”

Section: - Does Lower Extremity Deep Venous Thrombosis Arising After ...mentioning

confidence: 99%

Recommendations from the ICM-VTE: General

2022

Journal of Bone and Joint Surgery

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Postoperative Joint Replacement Complications in Swedish Patients With a Family History of Venous Thromboembolism

Cited by 9 publications

References 38 publications

Familial aggregation of multimorbidity in Sweden: national explorative family study

Familial aggregation of multimorbidity in Sweden: national explorative family study

Genetics of venous thromboembolism revised

Recommendations from the ICM-VTE: General

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