Postoperative memory prediction in left temporal lobe epilepsy: The Wada test is of no added value to preoperative neuropsychological assessment and MRI

Elshorst, N.; Pohlmann‐Eden, Bernd; Horstmann, Simone; Schulz, Reinhard; Woermann, Friedrich G.; McAndrews, Mary Pat

doi:10.1016/j.yebeh.2009.08.003

Cited by 36 publications

(33 citation statements)

References 44 publications

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“…The utility of Wada tests to predict postoperative memory outcome appears limited. 12,13 Besides selective Wada tests, the classic Wada test can also be confounded by a simultaneous effect on language functions. The decision for or against surgery in this patient group was mainly based on the laterality index of seizure onsets recorded by intracranial electrodes.…”

Section: Limitations Of the Studymentioning

confidence: 99%

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Vogt¹,

Malter²,

Schoene-Bake³

et al. 2014

JNS

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Object. The purpose of this study was to retrospectively assess the objective and subjective neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis (AHS).Methods. Memory and executive functions were evaluated at baseline and at follow-up in 11 surgically treated patients and compared with 8 pharmacologically treated patients with temporal lobe epilepsy and bilateral AHS. The median follow-up duration was 16 months in the surgically treated patients and 80.5 months in the pharmacologically treated group. Subjective outcome was evaluated by questionnaires and included mood, quality of life, subjective memory, and activities of daily living.Results. At the follow-up assessment, 82% of the surgically treated patients as opposed to 0% of the nonsurgery patients were seizure free. In the surgical group, nonverbal memory performance did not change significantly in any patient after surgery, but there was a floor effect in 55% of the surgical patients. Regarding verbal memory, 9% of the surgical patients improved while 73% declined, despite severe impairments already evident at baseline. In the nonsurgery control group, 13% of the patients declined in nonverbal memory (floor effect in 63%) and 25% declined in verbal memory (floor effect in 25%) at follow-up. None of the controls improved at follow-up. Executive functions remained unchanged on an impaired level in both groups. At follow-up, the patient groups did not differ significantly with respect to mood, quality of life, subjective memory, or activities of daily living. However, in most aspects, surgically treated patients reported a slightly better subjective outcome than pharmacologically treated patients and a significantly improved quality of life.Conclusions. These results suggest that beyond benefits concerning seizure control, surgically treated patients with bilateral AHS, despite already poor baseline performance, are still at risk for severe postoperative decline in memory. In the light of predominantly minor benefits on a subjective level, the findings put the overall outcome of epilepsy surgery in bilateral AHS patients into perspective. (http://thejns.org/doi/abs/10.3171/2014.7.JNS132037) key WordS • neuropsychological outcome • temporal lobe epilepsy surgery • memory • bilateral Ammon's horn sclerosis Abbreviations used in this paper: AHS = Ammon's horn sclerosis; BDI = Beck Depression Inventory; QOLIE = Quality of Life in Epilepsy Inventory; RCI = reliable change index; TLE = temporal lobe epilepsy; VLMT = Verbaler Lern-und Merkfähigkeitstest.

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Section: Limitations Of the Studymentioning

confidence: 99%

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Vogt¹,

Malter²,

Schoene-Bake³

et al. 2014

JNS

View full text Add to dashboard Cite

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“…La evaluación es exclusivamente de memoria verbal en 11 estudios 10,19,22,24,31,[33][34][35][36][37]39 , lo cual puede justificarse por el hecho de que el déficit más frecuente se asocia a este tipo de memoria, y es asimismo el más relevante clíni-camente. Solo hay un estudio 38 que evalúa exclusivamente la memoria no verbal, donde también se realizó un paradigma de RMf de memoria episódica no verbal.…”

Section: Batería De Test Neuropsicológicos Empleados En Los Estudiosunclassified

Evaluación de la memoria en la epilepsia del lóbulo temporal para predecir sus cambios tras la cirugía. Una revisión sistemática

Parra‐Díaz

García‐Casares

2019

Neurología

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“…Известно, что после резек-ции гиппокампа доминантного по речи полушария око-ло 35% пациентов демонстрируют худшие показатели при нейропсихологической оценке вербальной памяти [31]. Риск снижения вербальной памяти повышен в слу-чае позднего начала заболевания, высоких предопераци-онных показателей при тестировании, СГ доминантного полушария, минимальных изменений гиппокампа на МРТ -эти обстоятельства указывают на то, что эпилеп-тогенный гиппокамп может сохранять функциональную активность [31,32]. Тем не менее сложно определить, насколько снижение вербальной памяти влияет на по-слеоперационное качество жизни.…”

Section: лечение эпилепсии связанной со склерозом гиппокампаunclassified

Hippocampal sclerosis: pathogenesis, clinical features, diagnosis, and treatment

et al. 2016

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Postoperative memory prediction in left temporal lobe epilepsy: The Wada test is of no added value to preoperative neuropsychological assessment and MRI

Cited by 36 publications

References 44 publications

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Evaluación de la memoria en la epilepsia del lóbulo temporal para predecir sus cambios tras la cirugía. Una revisión sistemática

Hippocampal sclerosis: pathogenesis, clinical features, diagnosis, and treatment

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