Postoperative morbidity is an additional prognostic factor after potentially curative pancreaticoduodenectomy for primary duodenal adenocarcinoma

Malleo, Giuseppe; Tonsi, Alfredo; Marchegiani, Giovanni; Casarotto, Andrea; Paiella, Salvatore; Butturini, Giovanni; Bassi, Claudio

doi:10.1007/s00423-012-0978-9

Cited by 13 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Another study showed a 3-year survival rate of 87.5% for patients with node-negative patients and 21% for node-positive cases [8]. In contrast, Malleo et al reported that the nodal status did not correlate with overall survival [16]. Other studies have reported that the ratio of positive lymph nodes to total number of lymph node specimens resected is also a significant prognostic factor [15, 17].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China

Jiang

Huang

Chen

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

Aim. To evaluate the clinical risk factors influencing overall survival of patients with duodenal adenocarcinoma after potentially curative resection. Methods. A series of 201 patients with primary duodenal adenocarcinoma who underwent surgery from 1999 to 2014 at Chinese Medical Academic Cancer Hospital were studied by retrospective chart review and subsequent telephone follow-up. Results. Resectional surgery was performed in 138 of the 201 patients to attempt curative treatment, while 63 patients were treated with palliative surgery. Median survival of patients who underwent resectional operation was 57 months, whereas that of patients who had palliative surgery was shorter, 7 months (p < 0.001). For patients who underwent radical resection, the overall 1-, 3-, and 5-year survival rates were 87.3, 59.1, and 44.1%, respectively. Multivariate Cox regression analysis revealed that lymph node metastasis (HR 31.76, 2.14 to 470.8; p = 0.012) and vascular invasion (HR 3.75, 1.24 to 11.38; p = 0.020) were independent prognostic factors negatively associated with survival in patients undergoing curative resection. There was no survival difference between the groups treated by the pancreaticoduodenectomy (n = 20) and limited resection (n = 10) for early-stage duodenal adenocarcinoma (p = 0.704). Conclusions. Duodenal adenocarcinoma is a rare disease. Curative resection is the best treatment for appropriate patients. Lymph node metastases and vascular invasion are negative prognostic factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China

Jiang

Huang

Chen

et al. 2016

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Morbidity and mortality rates associated with surgical treatment for resectable duodenal cancer are high. Reported morbidity rates are around 40 per cent, and mortality rates range between 0 and 8·5 per cent ( Table S3 , supporting information).…”

Section: Discussionmentioning

confidence: 99%

“…Surgical resection offers the only chance of cure. There are few published studies on outcomes after surgery owing to the rarity of this condition. These studies are characterized by a limited number of patients and long study periods, resulting in conflicting reported outcomes.…”

Section: Introductionmentioning

confidence: 99%

Outcome after surgical resection for duodenal adenocarcinoma in the UK

Solaini

Jamieson

Metcalfe

et al. 2015

British Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…It is necessary to note that in our study only three (13.6 %) patients had positive resection margins, limiting the statistical significance. However, the lack of importance of resection margin status was also seen in other series [13,14].…”

Section: Analysis Of Predictive Factors For Survivalmentioning

confidence: 77%

“…Because of the rare nature of DAC there is limited information about the benefit of adjuvant or neoadjuvant radiochemotherapy and its effectiveness remains uncertain [5,6]. In contrast, several studies have proved the curative benefit of surgical therapy [4,[7][8][9][10][11][12][13][14]. Due to improvements in surgical technique and perioperative management, morbidity 1 3 and mortality rates have dropped consistently; 5-year survival rates average approximately 50 %, and reach up to 77 % in some series [4,14,15].…”

Section: Introductionmentioning

confidence: 98%

Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma

et al. 2015

View full text Add to dashboard Cite

Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma 1 1 3 Summary Background Sporadic duodenal cancer is a rare cancer entity. Therefore, the prognostic significance of clinicopathologic features is unknown. This study aimed to identify prognostic factors and compare survival with other tumour entities of the same anatomical region.Methods We retrospectively studied medical records of 22 patients with duodenal adenocarcinoma (DAC), who underwent resection in two German centres for pancreatic surgery (1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012). Mean time of follow-up was 51.3 months. Predictive factors were evaluated by log rank analysis.Results Whipple surgery was performed in seven cases (31.8 %), pylorus preserving pancreaticoduodenectomy in 14 cases (63.6 %) and partial duodenectomy in one case (4.5 %). R0-resection was achieved in 86.4 %. In all, 50% of our patients had nodal positive disease. Overall morbidity was 59.1 % and perioperative mortality was 9.1 %. Survival after resection was 63.6 % and 59.0 % (3-and 5-years). There was no significant survival difference between patients with DAC and ampullary cancer, but survival was longer compared with patients with pancreatic cancer.Conclusions Mortality seems to be high after resection of DAC. However, radical surgery should be performed due to the high number of patients with nodal positive disease. No definite prognostic factors were identified. The prognosis after resection of duodenal cancer can be compared with patients with ampullary cancer.

show abstract

Postoperative morbidity is an additional prognostic factor after potentially curative pancreaticoduodenectomy for primary duodenal adenocarcinoma

Cited by 13 publications

References 32 publications

Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China

Prognostic Factors and Clinical Characteristics of Patients with Primary Duodenal Adenocarcinoma: A Single-Center Experience from China

Outcome after surgical resection for duodenal adenocarcinoma in the UK

Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma

Contact Info

Product

Resources

About