Postpartum Autoimmune Thyroid Syndromes

Amino, Nobuyuki; Iwatani, Yoshinori; Tamaki, Haruo; Mori, Hidemitsu; Aozasa, Mieko; Miyai, Kiyoshi

doi:10.1016/b978-0-12-731950-6.50022-x

Cited by 24 publications

(13 citation statements)

References 15 publications

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“…SS is a well-known cause of postpartum autoimmune thyroiditis, and also the secondary AI of unknown origin were reported to be associated with autoimmune thyroid diseases [9]. Painless thyroiditis is recognized to occasionally occur following rapid development and/ or progression of primary or secondary adrenal failure, as immune rebound phenomenon [10]. Therefore, the concomitant Basedow's disease in our case might be caused by hypothalamic AI.…”

Section: Figmentioning

confidence: 74%

Postpartum hypothalamic adrenal insufficiency with remission: A rare case

et al. 2017

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Section: Figmentioning

confidence: 74%

Postpartum hypothalamic adrenal insufficiency with remission: A rare case

et al. 2017

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“…These patients would be diagnosed at the time of, or more preferably before, their onset, if high-risk women were screened in early-pregnancy and followed up during the postpartum period. Because it was estimated that the prevalence of new onset of Graves' disease among postpartum women in the general population is 0.15 percent in a previous report [7] and more (1/200) in a recent study by us (manuscript in preparation), the screening tests could justify their costs when the efficiency of the screening procedures is sufficiently high, and they would provide much benefit in the patient management and in improving the quality of life.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Postpartum Onset of Disease within Patients with Graves' Disease of Child-Bearing Age.

et al. 1994

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Abstract.To assess the prevalence of postpartum onset of disease among the patients with Graves' disease, we performed a retrospective examination of 289 consecutive female patients with Graves' disease who attended our thyroid clinic. Of these patients, 92 were female of child-bearing age (20-39 y.o.) who have had one or more deliveries, and at least 37 patients revealed clear evidences of postpartum onset of the disease. That is, at least 40% of Graves' patients of 20-39 y.o. developed their disease during the postpartum period.

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“…In addition, they also observed an increase in total B-lymphocytes, but a decrease of K-lymphocytes in a group of Graves' patients who showed post-partum relapse. In particular, in a patient with relapsed Graves' thyrotoxicosis there was a decrease of OKT3+ cells, although the changes in the OKT4/OKT8 ratio were similar to those found in normal pregnant controls (Amino et al 1985). …”

Section: Discussionmentioning

confidence: 83%

“…It should be mentioned that Amino et al (1985) found a significant increase in the percentage of OKT4 cells and thus an in¬ creased OKT4/OKT8 ratio in the third trimester and one month post partum in normal preg¬ nancies. In addition, they also observed an increase in total B-lymphocytes, but a decrease of K-lymphocytes in a group of Graves' patients who showed post-partum relapse.…”

Section: Discussionmentioning

confidence: 96%

T-lymphocyte subsets in pregnant women with Graves' disease

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Bellis

et al. 1987

Acta Endocrinologica

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T-lymphocyte subpopulations, anti-thyroid microsomal antibody titres, and free triiodothyronine and free thyroxine levels were investigated in 10 patients with Graves' disease before, during and after pregnancy. Twenty pregnant subjects and 100 normal age-matched, non-pregnant female volunteers served as controls.Pregnant patients with Graves' disease showed decrease levels of free triiodothyronine and free thyroxine, and decreased titres of anti-thyroid microsomal antibodies, with clinical remission during the second and third trimesters of pregnancy. Post partum, 9 patients showed clinical relapse, and all showed a return of enhanced levels of free triiodothyronine, free thyroxine and anti-thyroid microsomal antibodies.The percentage and absolute number of total T\ x=r eq-\ lymphocytes (OKT3+) and OKT4+ cells significantly decreased during pregnancy in patients with Graves' disease and in normal women. Post partum, OKT3+ and OKT4+ cells returned to pre-pregnancy levels in both groups. In Graves patients and in controls, the percentage and absolute number of OKT8+ cells during pregnancy and post partum were not significantly different from pre-pregnancy levels. Lastly, the OKT4+/ OKT8+ ratio, which decreased in normal subjects at the three sampling times during pregnancy, decreased only in the last two trimesters of pregnancy in patients with Graves' disease.

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Postpartum Autoimmune Thyroid Syndromes

Cited by 24 publications

References 15 publications

Postpartum hypothalamic adrenal insufficiency with remission: A rare case

Postpartum hypothalamic adrenal insufficiency with remission: A rare case

Prevalence of Postpartum Onset of Disease within Patients with Graves' Disease of Child-Bearing Age.

T-lymphocyte subsets in pregnant women with Graves' disease

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