Postpartum endogenous Candida endophthalmitis

Abstract

Postpartum endogenous fungal endophthalmitis in otherwise healthy females is extremely rare disease. We report a case of a 25-year-old female patient referred with a history of decreased vision in her right eye 1 month after uncomplicated vaginal delivery. She presented with multifocal chorioretinal infiltrates. The patient showed persistent inflammation in her right eye then after. Systemic workup was unremarkable apart from a history of vaginal discharge during peripartum period. Vaginal swap confirmed the presence of Candida albicans. Culture of the vitreous sample confirmed the growth of C. albicans. The patient was managed with intravitreal amphotericin B in addition to systemic antifungal treatment followed by pars plana vitrectomy. The patient achieved 20/40 vision with quiet eye after 6 months of follow-up.

Bilateral Endophthalmitis in a Postpartum Immunocompetent Patient

“…In the case we presented, all samples and cultures returned negative. In agreement with our presentation, 7 patients described by other authors also did not have any previous risk factors [ 11 – 13 , 16 , 18 – 20 ], whereas two had diabetes mellitus or other systemic issues [ 3 , 15 ]. Three patients had a vaginal infection during pregnancy [ 3 , 9 , 16 ].…”

“…Three patients had a vaginal infection during pregnancy [ 3 , 9 , 16 ]. Our patient had a mastitis following pregnancy similarly to another case described in literature [ 20 ] and achieved a 20/20 vision during the follow-up, in agreement with other patients who obtained an overall favorable visual prognosis [ 11 – 13 , 15 , 16 , 18 , 19 ]. Risk factors for the development of a mastitis include nipple excoriation, maternal stress, malnutrition or chronic medical conditions, nipple piercings, smoking, a tight bra, or an improper technique while breastfeeding.…”

“…Indeed, our patient has undergone this surgery two days after being referred to our department. Other ophthalmologists have chosen the same treatment option along with medical treatment [3,9,[11][12][13][14][15], For instance, a diagnostic core vitrectomy was performed in a postpartum fungal endogenous endophthalmitis in a young healthy woman [16]. In addition, other authors as well have already highlighted the benefit of this surgery [17].…”

Evaluation of the Ophthalmotoxic Effect of Quantum Dots and Bioconjugates Based on Them in Terms of the Prospects for the Treatment of Resistant Endophthalmitis. Experimental Research (Stage 1)

“…Показатели ЭРГ третьей группы соответствовали нормальным, поскольку регистрировался структурный ответ на световые импульсы (табл. 3,4).…”

“…В случаях грибковой этиологии процесса, вызванного дрожжевой микобиотой, используют препараты амфотерицины-B в дозировке 5-10 мкг. При плесневой грибковой инвазии применяют инъекции 100 мкг вориконазола [2,3]. Вирусный и паразитарный ЭФ (чаще именуемый увеитом) не имеет регламентированных стандартов хирургического лечения в настоящее время.…”