Postpartum hemorrhage: Could oxytocin be the cause? Results from a morbidity and mortality review to enhance quality, safety, and relevance of care

Parpex, Guillaume; Khediri, Zied; Michel, P.; Visbecq, Jean-Noël; M, Duviquet; Poncelet, Christophe

doi:10.1016/j.ejogrb.2021.01.019

Cited by 5 publications

(4 citation statements)

References 9 publications

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“…Motherwort injection is a colorless liquid of 20 mg hydrazine per 1 mL obtained by water extraction and alcohol precipitation of motherwort, advantageous formulation developed for motherwort, and it is widely used clinically to prevent and treat postpartum hemorrhage and promote postpartum uterine involution [ 15 ]. Qin Xianfen reported that the half-life of oxytocin is 1–6 minutes, motherwort injection is about 6 hours, and the combination of the two has a synergistic effect; when the effect of oxytocin diminishes, motherwort injection can still promote uterine contractions and enhance the hemostatic effect; it can effectively avoid the slow onset of motherwort [ 16 ]. Another report shows that oxytocin combined with motherwort injection can prolong the contraction time, effectively reduce bleeding, and promote uterine involution [ 17 ].…”

Section: Literature Reviewmentioning

confidence: 99%

Image Analysis Application of Motherwort Total Alkaloid Injection in the Treatment of Postabortion Hemorrhage

Wang

2022

Journal of Healthcare Engineering

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In order to reduce the possibility of postabortion hemorrhage leading to maternal death, the author studied the image analysis of postpartum hemorrhage based on Leonurus total alkaloid injection, combining research results, in order to explore the curative effect of Leonurus injection in treating postpartum hemorrhage. After treatment, the time and volume of vaginal bleeding were significantly lower than those in the control group ( P < 0.05 ); it is suggested that the combination of oxytocin and motherwort can effectively reduce the time and volume of vaginal bleeding after medical abortion, conducive to postoperative recovery. The results show that motherwort injection can effectively reduce the amount of bleeding and reduce the risk of postpartum hemorrhage; in addition, adverse reactions have been reduced, and an image analysis consensus has been formed, which is worthy of promotion.

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Section: Literature Reviewmentioning

confidence: 99%

Image Analysis Application of Motherwort Total Alkaloid Injection in the Treatment of Postabortion Hemorrhage

Wang

2022

Journal of Healthcare Engineering

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“…Oxytocin is the drug of choice for postpartum hemorrhage due to uterine inertia, as it is cheap, with a rapid onset of action. However, its duration of action is short, with the key disadvantage being saturation of the receptors [5]. Carboprost tromethamine is a novel prostaglandin preparation that effectively improves uterine smooth muscle contraction [6].…”

Section: Introductionmentioning

confidence: 99%

Effect of carboprost tromethamine and carbetocin on coagulation factors and prognosis in puerpera with postpartum hemorrhage due to uterine inertia

Chen,

Xiong,

Chen

et al. 2023

Trop. J. Pharm Res

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Purpose: To determine the effect of carboprost tromethamine and carbetocin on coagulation factors and prognosis in puerpera with postpartum hemorrhage due to uterine inertia.Methods: A total of 80 high-risk pregnant women with postpartum hemorrhage due to uterine inertia admitted to Longyan First Hospital Affiliated of Fujian Medical University, Longyan, China from June 2021 to June 2022 were randomly divided into control group (oxytocin + carboprost tromethamine, n = 40) and study group (oxytocin + carboprost tromethamine + carbetocin, n = 40). Vaginal bleeding volume was recorded for both groups at delivery, and 2 and 24 h after delivery. Decrease in hemoglobin level 24 h after delivery, as well as levels of coagulation factors, and adverse drug reactions before and after treatment were assessed.Results: The third stage of labor, postpartum hemorrhage at 2 and 24 h, and decrease in hemoglobin 24 h after delivery in the study group were lower (p < 0.05). Compared with that before treatment, PLT and FIB levels also fell, while APTT and PT levels rose in both groups after treatment for 24 h (p < 0.05). Platelet count and fibrinogen levels in the study group were lower after treatment for 24 h, but APTT and PT levels were higher (p < 0.05). There was no statistically significant difference in the incidence of adverse drug reactions between both groups (15.00 vs 12.50 %; p > 0.05).Conclusion: Co-administration of carboprost tromethamine with carbetocin prevents high-risk postpartum hemorrhage in pregnant women due to uterine inertia. It also reduces the level of bleeding, and promotes recovery of coagulation function. However, further clinical trials on a larger scale are recommended prior to the application of this treatment strategy in clinical practice.

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“…A study in Malawi showed that drug storage temperatures exceeded the recommended 25°C–30°C threshold for oxytocin in half of the 40 facilities assessed 59 . In another study in France, a large spike in cases of postpartum hemorrhage was ascribed to damage to an oxytocin batch during a heatwave, and rates of postpartum hemorrhage returned to baseline once a new batch of oxytocin was received 60 . High ambient temperatures may also undermine healthcare seeking behaviors during pregnancy 61 .…”

Section: Introductionmentioning

confidence: 99%

“… 59 In another study in France, a large spike in cases of postpartum hemorrhage was ascribed to damage to an oxytocin batch during a heatwave, and rates of postpartum hemorrhage returned to baseline once a new batch of oxytocin was received. 60 High ambient temperatures may also undermine healthcare seeking behaviors during pregnancy. 61 Many women wait in long queues to receive antenatal care, which is challenging during hot periods.…”

Section: Introductionmentioning

confidence: 99%

Increasing global temperatures threaten gains in maternal and newborn health in Africa: A review of impacts and an adaptation framework

Chersich

Scorgie

Filippi

et al. 2022

Intl J Gynecology & Obste

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Anatomical, physiologic, and socio-cultural changes during pregnancy and childbirth increase vulnerability of women and newborns to high ambient temperatures.Extreme heat can overwhelm thermoregulatory mechanisms in pregnant women, especially during labor, cause dehydration and endocrine dysfunction, and compromise placental function. Clinical sequelae include hypertensive disorders, gestational diabetes, preterm birth, and stillbirth. High ambient temperatures increase rates of infections, and affect health worker performance and healthcare seeking. Rising temperatures with climate change and limited resources heighten concerns. We propose an adaptation framework containing four prongs. First, behavioral changes such as reducing workloads during pregnancy and using low-cost water sprays. Second, health system interventions encompassing Early Warning Systems centered around existing community-based outreach; heat-health indicator tracking; water supplementation and monitoring for heat-related conditions during labor. Building modifications, passive and active cooling systems, and nature-based solutions can reduce temperatures in facilities. Lastly, structural interventions and climate financing are critical. The overall package of interventions, ideally selected following cost-effectiveness and thermal modeling trade-offs, needs to be codesigned and co-delivered with affected communities, and take advantage of existing maternal and child health platforms. Robust-applied research will set the stage for programs across Africa that target pregnant women. Adequate research and climate financing are now urgent.

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Postpartum hemorrhage: Could oxytocin be the cause? Results from a morbidity and mortality review to enhance quality, safety, and relevance of care

Cited by 5 publications

References 9 publications

Image Analysis Application of Motherwort Total Alkaloid Injection in the Treatment of Postabortion Hemorrhage

Image Analysis Application of Motherwort Total Alkaloid Injection in the Treatment of Postabortion Hemorrhage

Effect of carboprost tromethamine and carbetocin on coagulation factors and prognosis in puerpera with postpartum hemorrhage due to uterine inertia

Increasing global temperatures threaten gains in maternal and newborn health in Africa: A review of impacts and an adaptation framework

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