Poststreptococcal syndrome uveitis in South African children: Table 1

Abstract

This case series significantly increases the evidence for PSU currently available in the world literature. The condition can manifest with the full spectrum of ocular inflammation, and most cases respond well to standard uveitis regimens. The role of antibiotic therapy remains unclear and requires further investigation.

Patterns of Uveitis and Scleritis in Nepal: A Tertiary Referral Center Study

“…It has been reported mostly from Africa. 32,33 Among the scleritis cases, the high predominance of anterior scleritis seen in our study was similar to other reports (98-99%). 34,35 The female preponderance (46, 63%) seen in our study was similar to previous reports.…”

Uveitis Risk following Oral Fluoroquinolone Therapy: A Nested Case-control Study

“…Another possibility is that the systemic illness that prompted the use of antibiotics, rather than the antibiotics themselves, are a confounding factor and may be related to the development of uveitis. Postinfectious uveitis has been well-described, 18,19 and these infectious etiologies that can lead to the future development of uveitis may be treated with antibiotics. Furthermore, many cases of uveitis often present with a systemic prodrome that may resemble an infectious process and prompt the use of antibiotics.…”

Post-streptococcal scleritis: Corticosteroids avoid visual acuity loss

“…5 Since its first description by Cokingtin and Han 6 in 1991, cases of post-streptococcal uveitis have been reported, associated with scleritis only in two patients. 5,7 The diagnosis of a first case of post-streptococcal scleritis with no other eye disorder was retained because i) the patient had no sign of immune disorder (no symptom in the past, no significant rate of anti nuclear antibody, and no immune disorder one year after corticosteroid treatment was discontinued) ii) the scleritis occurred 10 days after the onset of a proven GAS tonsilitis, a time difference that is usual for other post-streptococcal immune disorders iii) the patient presented with hyperacute symptoms and intense chemosis, which are unusual in auto-immune systemic related scleritis. The current case of scleritis occurred despite the antibiotic treatment of the precessive GAS tonsillitis, suggesting that post-streptococcal scleritis would not be prevented by antibiotics.…”

“…In a recent series of 22 cases of poststreptococcal uveitis in South African children, none of them had sought recent health care advice. 7 Moreover, rapid improvement of post-streptococcal scleritis with corticosteroids might wrongly comfort the diagnosis of connective tissue-related scleritis for which such treatment is also beneficial. High doses of parenteral penicillin did not improve the symptoms, and confort the hypothesis of an immune post-infectious mechanism.…”