Postsurgical outcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis

Fong, Khi Yung; Lim, Mervyn Jun Rui; Fu, Shuning; Low, Chen Ee; Chan, Yiong Huak; Deepak, Doddabele Srinivasa; Xu, Xinni; Thong, Mark; Jain, Swati; Teo, Kejia; Gardner, Paul A.; Snyderman, Carl H.; Nga, Vincent Diong Weng; Yeo, Tseng Tsai

doi:10.1007/s11102-023-01335-2

Cited by 3 publications

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Radiation therapy may be needed to treat pituitary tumour remnants or functioning tumours resistant to medical treatment, as well as other parasellar tumours such as craniopharyngiomas or meningiomas; patients refusing or with contra-indications to surgery may also be eligible for primary irradiation treatment [ 94 , 95 , 96 , 97 , 98 ]. Radiation neuro-oncologists or radiotherapists managing patients with pituitary tumours must have a deep knowledge of the tolerance of the optic system, cranial nerves in the cavernous sinus, temporal lobes, and normal pituitary, and should be available in the Pituitary MDT/PTCOE [ 10 , 11 ].…”

Section: Characteristics Composition and Requirements Of The Pituitar...mentioning

confidence: 99%

Multidisciplinary Team Care in Pituitary Tumours

Marques,

Sagarribay,

Tortosa

et al. 2024

Cancers

View full text Add to dashboard Cite

The optimal care for patients with pituitary tumours is best provided in a multidisciplinary and collaborative environment, which requires the contribution of multiple medical specialties working together. The benefits and advantages of the pituitary multidisciplinary team (MDT) are broad, and all relevant international consensus and guidelines in the field recommend that patients with pituitary tumours should always be managed in a MDT. Endocrinologists and neurosurgeons are normally the leading specialties within the pituitary MDT, supported by many other specialties with significant contributions to the diagnosis and management of pituitary tumours, including neuropathology, neuroradiology, neuro-ophthalmology, and otorhinolaryngology, among others. Here, we review the literature concerning the concepts of Pituitary MDT/Pituitary Tumour Centre of Excellence (PTCOE) in terms of their mission, goals, benefits, structure, proposed models of function, and barriers, and we also provide the views of different specialists involved in our Pituitary MDT.

show abstract

Section: Characteristics Composition and Requirements Of The Pituitar...mentioning

confidence: 99%

Multidisciplinary Team Care in Pituitary Tumours

Marques,

Sagarribay,

Tortosa

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

“…Fong et al [49] Sellar Meta-analysis including eleven studies comprised of 3941 patients undergoing expanded endoscopic endonasal resection for pituitary tumors were evaluated.…”

Section: Authors Approach Study Inclusion Outcomesmentioning

confidence: 99%

Operative Corridors in Endoscopic Skull Base Tumor Surgery

Ahmed,

Rowan,

Mukherjee

2024

Brain Sciences

View full text Add to dashboard Cite

Advances in technology, instrumentation, and reconstruction have paved the way for extended endoscopic approaches to skull base tumors. In the sagittal plane, the endonasal approach may safely access pathologies from the frontal sinus to the craniocervical junction in the sagittal plane, the petrous apex in the coronal plane, and extend posteriorly to the clivus and posterior cranial fossa. This review article describes these modular extended endoscopic approaches, along with crucial anatomic considerations, illustrative cases, and practical operative pearls.

show abstract

Pituitary Apoplexy: Comorbidities, Management, and Outcomes—A Spanish Observational Multicenter Study

Biagetti,

Cordero Asanza,

Pérez-López

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Background Pituitary apoplexy (PA) is the paradigm of endocrine and neurosurgical emergency. Objective To evaluate the comorbidities, risk factors, clinical presentation, pituitary apoplexy score (PAS) and the outcomes of surgical vs. conservative management of PA in Spain. Methods Spanish multicenter, observational study of 301 patients with acute PA. Statistical analyses compared risk factors, clinical presentation and outcomes between the surgical and conservative treatment groups, adjusting for potential confounders. The prevalence of cardiovascular risk factors in patients with pituitary apoplexy was compared with the Spanish population and with patients with non-functioning pituitary adenomas. Results Median age was 59.3 years, 201 (66.8%) were men and non-functioning adenomas (77.9%) were the most common tumor type. The prevalence of diabetes (20.3% vs 13.9%, p<0.01), hypertension (48.8% vs 33.4%, p<0.01) and dyslipidemia (44.2% vs 23.3%, p<0.01), exceeded the Spanish age-adjusted population prevalence. Overall, 209 (69.4%) underwent surgery and 92 (30.6%) received conservative treatment. Surgical patients had larger tumors (26.2 vs 21.0 mm, p<0.01), chiasmal compression more frequently (77.2% vs 53.4%, p<0.01) and higher values of PAS. In the follow-up, while there were no statistically significant differences in anterior pituitary hormonal deficits between treatments, permanent vasopressin deficiency was more frequent after surgery (14.8% vs 3.3%, p<0.01). Conclusion There is a high burden of cardiovascular risk factors among patients with PA suggesting that metabolic factors may play a potential role in the development of PA. This underscores the need for comprehensive management of these conditions in addition to treating the apoplexy itself in this population. Surgical management has a relevant place in PA approach mainly in patients with higher PAS. However, it leads permanent vasopressin deficit more frequently than conservative approach.

show abstract

Postsurgical outcomes of nonfunctioning pituitary adenomas: a patient-level meta-analysis

Cited by 3 publications

References 67 publications

Multidisciplinary Team Care in Pituitary Tumours

Multidisciplinary Team Care in Pituitary Tumours

Operative Corridors in Endoscopic Skull Base Tumor Surgery

Pituitary Apoplexy: Comorbidities, Management, and Outcomes—A Spanish Observational Multicenter Study

Contact Info

Product

Resources

About