“…Patients harbouring a glioma often suffer from a significant symptom burden: Apart from neurological and neurocognitive deficits, seizures, fatigue, depression and anxiety are the main symptoms throughout the disease course and should be managed actively (Ford et al, 2012;Goebel, Stark, Kaup, von Harscher, & Mehdorn, 2011;Heese et al, 2013;Renovanz et al, 2013;Struik et al, 2009;Walbert, 2014). At the end of life, the symptom burden increases and the majority of the patients lose decision-making capacity.…”