Postsynaptic glutamate response downregulates within presynaptic exaggerated glutamate release by activating TRPV1 in the spinal dorsal horn

Zhang, Mingming; Zhang, Mingzhe; Wei, Yawen; Lu, Ya-Cheng; Wang, Jian; Yang, Shan-Ming; Zhu, Ziying; Chen, Qian; Zhao, Mingwei; Dong, Jiaxue; Yang, Xingwu J; Yang, Kun

doi:10.1016/j.bbrc.2022.07.075

Cited by 2 publications

(1 citation statement)

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“…TRPV1 and TRPA1 have been found to be involved in causing pain in diabetic rats affected by peripheral neuropathy [ 107 ]. In an animal study, the activation of TRPV1 in the spinal cord by capsaicin produced excessive glutamate liberation causing acute pain [ 108 ]. A randomized control trial on patients affected by neuropathic pain reported a reduction of pain after treatment with capsaicin patches [ 109 ].…”

Section: Cannabinoids In Pancreatic Cancer Treatmentmentioning

confidence: 99%

Perineural Invasion in Pancreatic Ductal Adenocarcinoma: From Molecules towards Drugs of Clinical Relevance

Selvaggi

Melchiorre

Casari

et al. 2022

Cancers

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Pancreatic ductal adenocarcinoma is one of the most threatening solid malignancies. Molecular and cellular mediators that activate paracrine signalling also regulate the dynamic interaction between pancreatic cancer cells and nerves. This reciprocal interface leads to perineural invasion (PNI), defined as the ability of cancer cells to invade nerves, similar to vascular and lymphatic metastatic cascade. Targeting PNI in pancreatic cancer might help ameliorate prognosis and pain relief. In this review, the modern knowledge of PNI in pancreatic cancer has been analysed and critically presented. We focused on molecular pathways promoting cancer progression, with particular emphasis on neuropathic pain generation, and we reviewed the current knowledge of pharmacological inhibitors of the PNI axis. PNI represents a common hallmark of PDAC and correlates with recurrence, poor prognosis and pain in pancreatic cancer patients. The interaction among pancreatic cancer cells, immune cells and nerves is biologically relevant in each stage of the disease and stimulates great interest, but the real impact of the administration of novel agents in clinical practice is limited. It is still early days for PNI-targeted treatments, and further advanced studies are needed to understand whether they could be effective tools in the clinical setting.

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Section: Cannabinoids In Pancreatic Cancer Treatmentmentioning

confidence: 99%