Posttransplant Inflammation Associated With Onset of Chronic Kidney Disease

Sancho, A.; Pastor, M.C.; Bayés, Beatriz; Sánchez, Alcides Antúnez; Morales‐Indiano, Cristian; Doladé, Maria; Romero, R.; Lauzurica, Ricardo

doi:10.1016/j.transproceed.2010.07.075

Cited by 12 publications

(2 citation statements)

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“…The disease is mainly caused by the glomerular injury mediated by an immune reaction, including humoral immunity and cell-mediated immunity. In the pathology of CGN, humoral immunity and cell-mediated immunity mechanisms play an important role, as the immune complex causes changes to GN (Sancho et al, 2010). As indicated by modern medicine research, CGN is related to disordered immune stability.…”

Section: Discussionmentioning

confidence: 99%

Effects and mechanism of Tripterygium wilfordii on chronic glomerulo nephritis

Pei¹,

Yang²,

Zhang

2016

Genet. Mol. Res.

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ABSTRACT. The objective of this study was to investigate the clinical effects of Tripterygium wilfordii on chronic glomerulo nephritis (CGN) and its mechanisms. Eighty-two cases of CGN treated in our hospital were randomly divided into observation and control groups. The control group was treated with conventional western medicine, and the observation group was treated with conventional western medicine and orally-administered T. wilfordii pills for three courses of treatment, each consisting of 4 weeks. Changes in serum creatinine, blood urea nitrogen, blood total cholesterol, blood albumin, and 24-h urine protein were observed. The levels of peripheral tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined with enzyme-linked immunosorbent assay. The curative effects of both groups were evaluated respectively. Both groups had significantly improved serum creatinine, blood urea nitrogen, blood total cholesterol, blood albumin, and 24-h urine protein (P < 0.05), and the observation group exhibited a more significant improvement (P < 0.05). TNF-α and IL-6 levels in both groups obviously decreased (P < 0.05), and the observation group exhibited remarkable changes (P < 0.05). After treatment, the total efficiency of the observation group was 90.24%, which was significantly higher than the 73.17% of the control group (P < 0.05). In conclusion, T. wilfordii can significantly improve kidney function and clinical symptoms in CGN patients, and the mechanism is possibly related to its inhibition of the secretion of TNF-α and IL-6.

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Section: Discussionmentioning

confidence: 99%

Effects and mechanism of Tripterygium wilfordii on chronic glomerulo nephritis

Pei¹,

Yang²,

Zhang

2016

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…The investigators observed that persistent inflammation is also associated with progression of fibrosis and poor allograft survival [7]. In another study, Sancho et al [14] performed a cross-sectional study with 207 RT recipients and investigated early post-transplant CRP levels on graft function; they showed the predictive role of inflammation on renal dysfunction.…”

Section: Discussionmentioning

confidence: 99%