Posttransplant Renal Allograft Dysfunction – A Retrospective Observational Study

Abstract

Background: In India, a large number of end-stage renal disease patients are undergoing renal replacement therapy. A successful renal transplantation relives the burden of dialysis with improved quality of life and a productive life thereafter. This also reduces the cost of health care to the government and the society. Graft dysfunction is an important cause of graft loss. The objective of this retrospective study is to evaluate the graft dysfunction and its impact on patient and graft survival. Methods: We did a retrospective record-based analysis of 83 cases (including both deceased and live-related renal transplants) from 2014 to 2019 who were on triple immunosuppression (tacrolimus, mycophenolate mofetil, and steroids) as maintenance therapy. Patients who had graft dysfunction, underwent graft biopsy and were analyzed subsequently. Results: The most common causes for graft dysfunction on biopsy were acute rejection, acute tubular injury, and calcineurin inhibitor toxicity. About 39% of the patients had infections, predominantly bacterial and viral infections. The rejections were associated with poor patient survival (statistically significant). The overall patient survival at our center after 1 year and 3 years was 88% and 84%, respectively, while the death-censored graft survival was 86% and 81%, respectively. Conclusion: In our center, following renal transplantation, patients had a fairly successful outcome. However, early detection and prompt management of the graft dysfunction can improve the graft and the patient survival.

Role of Urine Examination in Renal Transplant Recipients

“…Before discussing about the role of urinalysis, it is important to determine the reasons for renal allograft dysfunction [9,10]. Renal allograft dysfunction may be acute or late, the causes can broadly be classified as immunological or non-immunological.…”

“…Urine analysis can help in diagnosis, follow-up and as well help in determining the graft outcome. Urinary abnormalities, such as hematuria or casts, are also useful in detecting and diagnosing allograft dysfunction [8,9].…”