Postweaning social isolation enhances morphological changes in the neonatal ventral hippocampal lesion rat model of psychosis

Alquicer, Glenda; Morales‐Medina, Julio César; Quirion, Rémi; Flores, Gonzalo

doi:10.1016/j.jchemneu.2007.10.001

Cited by 69 publications

(73 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The morphology of NAc neurons, especially the medium spiny neurons in the NAcc, has been examined in male SD rats isolated from P21 to P77. The total dendritic length is reduced in isolation-reared rats while the spine density is not changed (Alquicer et al 2008), same with our present findings in male Wistar rats.…”

Section: Discussionsupporting

confidence: 92%

“…The number of intersections in the isolated rats was reduced (Fig. 7c) which is comparable to the finding of Alquicer et al (2008). The overall distributions of bifurcation nodes and terminal endings in the two groups of animals were similar (Fig.…”

Section: Dopamine Neurons In the Midbrainsupporting

confidence: 79%

“…In postweaning socially isolated rats, dendritic features have been studied in neurons of the mPFC and NAc. In layer II/III mPFC pyramidal neurons, the number of dendritic segments and dendritic complexity are reduced in male SD rats isolated from P18 to P32 (Pascual et al 2006) and the spine density is decreased in male SD rats isolated from P21 to P77 (Silva-Gómez et al 2003;Alquicer et al 2008). In the present study, we quantified dendritic features in both apical and basilar dendrites of layer II/III pyramidal mPFC neurons.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation

Wang

et al. 2011

Brain Struct Funct

View full text Add to dashboard Cite

The mesocorticolimbic system contains dopamine (DA)-producing neurons in the ventral tegmental area (VTA) and their projection targets, including the medial prefrontal cortex (mPFC), amygdala (AMY) and nucleus accumbens (NAc). Disruption of this system might attribute to mental illnesses. In the present study, we adopted the postweaning social isolation paradigm to model neuropsychiatric disorders and studied the functional and structural changes of the mesocorticolimbic system. After 8-9 weeks of isolation, rats exhibited hyperlocomotor activity and impaired sensorimotor gating compared to group-reared controls. However, the number of tyrosine hydroxylase-positive VTA neurons and the volume of VTA were not affected. Comparing with group-reared controls, the DA levels in the isolation-reared were not altered in the VTA, mPFC and NAc but decreased in the AMY. In the structural aspect, dendritic features of layer II/III pyramidal mPFC neurons; pyramidal neurons in the basolateral nucleus of amygdala (BLA) and medium spiny neurons in the core region of the NAc (NAcc) were examined. Interestingly, the neuronal changes were region-specific. The mPFC neurons had reduced dendritic complexity, spine density and elongated terminal branches. The BLA neurons had extensive dendritic arbors with short branches but unchanged spine density. The NAcc neurons had reduced total dendritic length but the segment length and spine density remained the same. Together, the results demonstrated the structural and functional changes in the mesocorticolimbic DA system of socially isolated rats. These changes may account for the behavioral impairments in these rats and attribute to the susceptibility to mental disorders related to schizophrenia and depression.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Dopamine Neurons In the Midbrainsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation

Wang

et al. 2011

Brain Struct Funct

View full text Add to dashboard Cite

show abstract

“…These behaviors include hyperresponsiveness to novel environment and psychostimulant administration [9]- [11], deficits in sensory gating [12] and working memory impairments [13], which appear only after puberty. Additionally, nVHL induces neuronal rearrangements [14] [15], disrupted cholinergic and dopaminergic (DA) transmission [16] [17], as observed in schizophrenic patients.…”

Section: Introductionmentioning

confidence: 99%

Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion

Jaramillo¹,

Cruz²,

Vargas³

et al. 2014

Self Cite

View full text Add to dashboard Cite

The effect of chronic administration of the sigma agonist: 1,3-di-o-tolyl-guanidine (DTG), in neonatal ventral hippocampal lesioned (nVHL) rats, on the immobility by clamping and dorsal immobility, were investigated. The nVHL increases the duration of immobility by clamping, but does not affect the duration of the dorsal immobility. We found that DTG augments the duration of the dorsal immobility in the unlesioned rats, but does not modify the duration of immobility induced by clamping the neck. DTG also counteracts the increase in the duration of the immobility by clamping produced by nVHL. However, the increase in the duration of the dorsal immobility produced by DTG is counteracted by nVHL. These results are discussed with respect to the differential effect on the two immobility responses tested, suggesting that they are different forms of immobility mediated by different mechanisms although they behaviorally share common characteristics.

show abstract

“…certain combinations of the above mentioned models to investigate the hypothesis that these manipulations can enhance the reliability of the schizophrenia model [16,[86][87][88]. One of the most popular methods is the gene-enviromental interactions, including ventral hippocampal lesion with social isolation which produced an additive effect on locomotor activity and morphological changes in the prefrontal cortex and NAcc [89,90]. Neonatal immune activator, polyinosinic-polycytidylic acid (polyI: C), treatment as an environmental factor in DISC1 transgenic mice results in a synergistic effect in the deficits of short-term memory after puberty, although polyI: C treatment or DN-DISC1 expression by itself has little influence on wild type mice [91].…”

Section: Complex Modelsmentioning

confidence: 99%

Development and characterization of chronic animal models of schizophrenia

Petrovszki¹

View full text Add to dashboard Cite

Postweaning social isolation enhances morphological changes in the neonatal ventral hippocampal lesion rat model of psychosis

Cited by 69 publications

References 80 publications

Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation

Differential neuronal changes in medial prefrontal cortex, basolateral amygdala and nucleus accumbens after postweaning social isolation

Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion

Development and characterization of chronic animal models of schizophrenia

Contact Info

Product

Resources

About