Potassium and Sodium Distribution in Cardiac Failure

Cox, J. R.; Horrocks, P; Speight, Carol J.; Pearson, Rosemary E.; Hobson, Norma

doi:10.1042/cs0410055

Cited by 27 publications

(14 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It also may play a role in several other disorders including de pression and dementia [Cox et al, 1971[Cox et al, , 1971b, confusion and heart failure [Cox et al" 1971a],…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Potassium Changes with Age

Cox¹,

Shalaby²

1981

Gerontology

View full text Add to dashboard Cite

Measurements of total exchangeable potassium and total exchangeable sodium, total body water and extracellular fluid volumes were made in 69 patients aged 30–90+ years, using multiple isotope techniques. The patients were not suffering from any chronic disorder or having potassium or diuretic therapy and were considered to be having a normal hospital diet. The study showed a direct correlation between potassium and age, in that total exchangeable potassium decreased as age increased. The same relation was obtained when total exchangeable potassium was related to dry body weight and fat-free body water to age. Although total exchangeable sodium diminished with increasing age, the ratio of total exchangeable potassium was approximately 1 at 30 years of age rising to approximately 2 at 90+ years of age.

show abstract

“…It also may play a role in several other disorders including de pression and dementia [Cox et al, 1971[Cox et al, , 1971b, confusion and heart failure [Cox et al" 1971a],…”

Section: Discussionmentioning

confidence: 99%

“…The method has been described in detail by Veall and Vetter [1958] and by Cox et al [1971aCox et al [ , 1971b. K,.…”

Section: Methodsmentioning

confidence: 99%

Potassium Changes with Age

Cox¹,

Shalaby²

1981

Gerontology

View full text Add to dashboard Cite

show abstract

“…Measurements of TBW, ECF, total Nae and total Ke were made before and after the 2 weeks lithium treatment in the two depressed groups and also in the 6 control subjects who were not considered to be depressed. The measurements were made using multiple isotope dilution techniques involving radioactive tritium, sulphate, sodium and potassium irons, following the experimental procedure of Veall and Vetter (1968) and Cox et al (1971). Plasma and urine sodium and potassium levels were measured by the EEL model 150 clinical flame photometer.…”

Section: Methodsmentioning

confidence: 99%

Lithium in Depression

Cox¹,

Pearson²,

Brand³

1977

Gerontology

Self Cite

View full text Add to dashboard Cite

Two groups of depressed subjects, one with a history of recurrent depression, the other with a history of persistent apathy, were given lithium carbonate 1,200 mg q.i.d. and supplementary potassium 1,200 mg t.d.s. for 1 week. Measurements were made before and after the lithium treatment of total body water (tritium space), extracellular fluid (sulphate space), total exchangeable sodium (Na_e) and total exchangeable potassium (K_e) using sodium-24 and potassium-42 multiple isotope dilution techniques. Prior to treatment when compared with a group of normal subjects, both depressed groups showed changes in body fluid volumes and electrolyte levels. Total body water, intracellular fluid and intracellular potassium were lowered, while intracellular sodium was raised. After treatment with lithium the values in the apathetic group showed little change but the group with recurrent depression showed a significant increase in intracellular fluid (p < 0.025), K_e (p < 0.001), intracellular potassium (p < 0.025) and a significant decrease in Na_e (p < 0.05). There was a marked increase in mood in the group with recurrent depression but not in the apathetic group following lithium treatment. These findings suggest that recurrent depression, both in clinical improvement, mood and also correction of water and electrolyte disturbances arise, but not in patients with long-standing apathy.

show abstract

“…We have measured total body water (TBW), extracellular fluid (ECF), total exchange able sodium (Nae), total exchangeable potassium (Ke), using a multiple isotope dilution technique [Cox et at., 1971]. Veall and Vetter [1958].…”

Section: Methodsmentioning

confidence: 99%

“…In congestive cardiac failure it has been shown that potassium deficiency occurs and that following treatment with diuretics and potassium supple mentation, an increase in the total body potassium occurs [Cox et al, 1971], It has been suggested [Lant et al, 1969;Bec et al, 1969], that amiloride con serves body potassium and that treatment with 'Moduretic', a proprietary tablet of 5 mg of amiloride hydrochloride and 50 mg of hydrochlorothiazide, results in an increase of body potassium [Hefferman et al, 1969].…”

Section: Introductionmentioning

confidence: 99%