2016
DOI: 10.1016/j.toxicon.2016.06.016
|View full text |Cite
|
Sign up to set email alerts
|

Potassium channel blockers from the venom of the Brazilian scorpion Tityus serrulatus ( )

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
4
0
1

Year Published

2017
2017
2023
2023

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 16 publications
(6 citation statements)
references
References 68 publications
1
4
0
1
Order By: Relevance
“…In the venom of C. edwardsii, two more fragments (CedP1a and CedP2a) were detected, matching peptides affecting potassium channels, and were described as potent inhibitors of voltage-gated potassium channels [ 40 , 41 ]. Although there is no previous report of the peptide or protein content of these two Buthidae scorpions from Colombia ( T. asthenes and C. edwardsii ), venom characterization of other Buthidae indicates that neurotoxins are the major content of these venoms, just as seen in our results [ 42 - 44 ]. We found four more fragments (TaP1a, TaP1b, TaP14a and CedP4a) from T. asthenes and C. edwardsii that are similar to antimicrobial peptides (AMP), active against Gram-negative and Gram-positive bacteria and fungi [ 13 ].…”
Section: Discussionsupporting
confidence: 59%
“…In the venom of C. edwardsii, two more fragments (CedP1a and CedP2a) were detected, matching peptides affecting potassium channels, and were described as potent inhibitors of voltage-gated potassium channels [ 40 , 41 ]. Although there is no previous report of the peptide or protein content of these two Buthidae scorpions from Colombia ( T. asthenes and C. edwardsii ), venom characterization of other Buthidae indicates that neurotoxins are the major content of these venoms, just as seen in our results [ 42 - 44 ]. We found four more fragments (TaP1a, TaP1b, TaP14a and CedP4a) from T. asthenes and C. edwardsii that are similar to antimicrobial peptides (AMP), active against Gram-negative and Gram-positive bacteria and fungi [ 13 ].…”
Section: Discussionsupporting
confidence: 59%
“…To the best of our knowledge, only two peptides are known in the literature that have modulated the Kv1.5 ion current: Osu1 [91] and Ts6 [92,93]. Osu1 is a peptide isolated from the venom of a tarantula, called Oculicosa supermirabilis.…”
Section: Osu1 and Ts6: The Known Peptide Modulators Of The Kv15mentioning
confidence: 99%
“…T . serrulatus venom has been extensively studied, mainly the sodium and potassium channel toxin [ 12 , 13 , 18 , 19 ]. Other components with low molecular mass such as hypotensins, antimicrobial peptides, bradykinin-potentiating peptides and high molecular mass such as enzymatic components like hyaluronidases, serino proteinases, metalloproteinase and proteinase inhibitors were also detected in T .…”
Section: Introductionmentioning
confidence: 99%