Potassium in Solid Cancers

Iorio, Jessica; Lastraioli, Lisa; Lastraioli, Elena

doi:10.5772/intechopen.101108

Cited by 2 publications

(3 citation statements)

References 64 publications

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“…Potassium is one of the most important electrolytes in the human body, as it is involved in maintaining the integrity of the skeleton, regulation of muscle contraction, blood pressure and nerve transmission. It is essential for the proper activity of all cells 74 , 75 . Hyperkalemia is a common disorder in patients suffering from cancers.…”

Section: Discussionmentioning

confidence: 99%

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Glioblastoma multiforme influence on the elemental homeostasis of the distant organs: the results of inter-comparison study carried out with TXRF method

Wilk,

Setkowicz,

Banas

et al. 2024

Sci Rep

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Glioblastoma (GBM) is a fast-growing and aggressive brain tumor which invades the nearby brain tissue but generally does not spread to the distant organs. Nonetheless, if untreated, GBM can result in patient death in time even less than few months from the diagnosis. The influence of the tumor progress on organs other than brain is obvious but still not well described. Therefore, we examined the elemental abnormalities appearing in selected body organs (kidney, heart, spleen, lung) in two rat models of GBM. The animals used for the study were subjected to the implantation of human GBM cell lines (U87MG and T98G) characterized by different levels of invasiveness. The elemental analysis of digested organ samples was carried out using the total reflection X-ray fluorescence (TXRF) method, independently, in three European laboratories utilizing various commercially available TXRF spectrometers. The comparison of the data obtained for animals subjected to T98G and U87MG cells implantation showed a number of elemental anomalies in the examined organs. What is more, the abnormalities were found for rats even if neoplastic tumor did not develop in their brains. The most of alterations for both experimental groups were noted in the spleen and lungs, with the direction of the found element changes in these organs being the opposite. The observed disorders of element homeostasis may result from many processes occurring in the animal body as a result of implantation of cancer cells or the development of GBM, including inflammation, anemia of chronic disease or changes in iron metabolism. Tumor induced changes in organ elemental composition detected in cooperating laboratories were usually in a good agreement. In case of elements with higher atomic numbers (Fe, Cu, Zn and Se), 88% of the results were classified as fully compliant. Some discrepancies between the laboratories were found for lighter elements (P, S, K and Ca). However, also in this case, the obtained results fulfilled the requirements of full (the results from three laboratories were in agreement) or partial agreement (the results from two laboratories were in agreement).

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Section: Discussionmentioning

confidence: 99%

“…Low potassium in the spleen detected in our study may be related to the anemia caused by tumors progression. Despite the appropriate level of potassium in erythrocytes, the lower number of red blood cells undergoing lysis in the spleen may translate into the reduced level of the element within the organ 74 , 78 , 79 .…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma multiforme influence on the elemental homeostasis of the distant organs: the results of inter-comparison study carried out with TXRF method

Wilk,

Setkowicz,

Banas

et al. 2024

Sci Rep

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“…K channels are involved in the regulation of many cellular processes including cell proliferation and apoptosis. The K homeostasis is frequently changed in tumor cells with both a reduction (hypokalemia) or an increase (hyperkalemia) being observed [62].…”

Section: Discussionmentioning

confidence: 99%

Optical Emission Spectroscopy for the Real-Time Identification of Malignant Breast Tissue

Guergan,

Boeer,

Fugunt

et al. 2024

Diagnostics

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Breast conserving resection with free margins is the gold standard treatment for early breast cancer recommended by guidelines worldwide. Therefore, reliable discrimination between normal and malignant tissue at the resection margins is essential. In this study, normal and abnormal tissue samples from breast cancer patients were characterized ex vivo by optical emission spectroscopy (OES) based on ionized atoms and molecules generated during electrosurgical treatment. The aim of the study was to determine spectroscopic features which are typical for healthy and neoplastic breast tissue allowing for future real-time tissue differentiation and margin assessment during breast cancer surgery. A total of 972 spectra generated by electrosurgical sparking on normal and abnormal tissue were used for support vector classifier (SVC) training. Specific spectroscopic features were selected for the classification of tissues in the included breast cancer patients. The average classification accuracy for all patients was 96.9%. Normal and abnormal breast tissue could be differentiated with a mean sensitivity of 94.8%, a specificity of 99.0%, a positive predictive value (PPV) of 99.1% and a negative predictive value (NPV) of 96.1%. For 66.6% patients all classifications reached 100%. Based on this convincing data, a future clinical application of OES-based tissue differentiation in breast cancer surgery seems to be feasible.

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Potassium in Solid Cancers

Cited by 2 publications

References 64 publications

Glioblastoma multiforme influence on the elemental homeostasis of the distant organs: the results of inter-comparison study carried out with TXRF method

Glioblastoma multiforme influence on the elemental homeostasis of the distant organs: the results of inter-comparison study carried out with TXRF method

Optical Emission Spectroscopy for the Real-Time Identification of Malignant Breast Tissue

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