Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study

Anzengruber, Florian; Mergenthaler, Caroline; Murer, Christian; Dummer, Reinhard

doi:10.1159/000494614

Cited by 15 publications

(9 citation statements)

References 25 publications

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“…Potassium iodide (KI) is another treatment that has been suggested for GA, although recent studies yield disappointing results. An 11-patient retrospective study found that KI led to improvement in only four patients [ 94 ]. Furthermore, in the retrospective study by Nordmann et al, of the 12 patients treated with KI, none experienced complete resolution, three experienced partial resolution, two had stable disease, and two had GA progression [ 59 ].…”

Section: Review Of Management Optionsmentioning

confidence: 99%

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Joshi

Duvic

2021

Am J Clin Dermatol

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Granuloma annulare (GA) is an inflammatory granulomatous skin disease that can be localized (localized GA) or disseminated (generalized GA), with patch, perforating, and subcutaneous subtypes being less common variants of this benign condition. Recently, new research has emerged that further elucidates GA epidemiology and etiopathogenesis; importantly, new therapeutic options for GA have also been described, although there remains a paucity of randomized controlled studies. In this review, we summarize recent updates on GA epidemiology and etiopathogenesis and offer an updated review of the therapeutic options for GA currently reported in the literature. We hope that the current review galvanizes randomized controlled studies that will in turn help lead to the recommendation of evidence-based treatments for GA.

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Section: Review Of Management Optionsmentioning

confidence: 99%

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Joshi

Duvic

2021

Am J Clin Dermatol

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“…also highlighted a disappointing response to dapsone, with only three of seven patients noting improvement. Anzengrueber et al 25 . show poor response of NL to potassium iodide, with only two of seven patients noting amelioration.…”

Section: Discussionmentioning

confidence: 97%

“…Anzengrueber et al 25 show poor response of NL to potassium iodide, with only two of seven patients noting amelioration.…”

Section: Groupmentioning

confidence: 96%

Treatment options for necrobiosis lipoidica: a systematic review

Nihal,

Caplan,

Rosenbach

et al. 2023

Int J Dermatology

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BackgroundNecrobiosis lipoidica (NL) is a rare, idiopathic, and recalcitrant disease of collagen degeneration for which treatment options have been poorly studied. Due to its recurring nature, risk for ulceration, and high morbidity, there is a need to understand existing treatment modalities to better inform clinical care.ObjectiveThis review aims to describe the therapeutic modalities reported in the literature for the treatment of NL.MethodsA literature search of treatments was performed by searching for publications between January 2016 and May 2022 on PubMed and Scopus. Given the limited high‐quality evidence, case reports and series were included. Only publications presenting information on both attempted treatments and outcomes were included.ResultsA total of 60 novel articles were identified (54 case reports, two case series, and four retrospective cohort studies). These studies cumulatively reported on 274 patients and covered treatments including phototherapy, topical corticosteroids, topical calcineurin inhibitors, biologics, immunosuppressants, JAK inhibitors, combination therapies, and several others. The greatest amount of evidence was found for photodynamic therapy (improvement in 72 of 80 patients), UVA‐based phototherapy (12 of 33), topical corticosteroids (21 of 46), compression therapy (15 of 20), and topical calcineurin inhibitors (11 of 17). Several newer treatments were also described, including ustekinumab and JAK inhibitors.ConclusionsThis systematic review provides a comprehensive summary of recently published treatments for NL. As the existing data comes predominantly from case reports and series, statistical conclusions are not assessed. A greater number of randomized controlled trials with standardized endpoints are necessary to compare treatment efficacy.

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“…The poor pathomechanistic understanding of panniculitis clinically translates into overall unspecific therapeutic approaches. These consist of mechanical compression combined with systemic anti-inflammatory agents such as non-steroidal anti-inflammatory drugs or, in unresponsive cases, immunosupressive medications such as corticosteroids (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Spatial mapping of subcutaneous adipose tissue microenviounment in panniculitis: Unveiling novel immune signatures

Brüggen,

Ziadlou,

Ameri

et al. 2023

Preprint

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Panniculitis, characterized by inflammation of the subcutaneous adipose tissue, displays diverse clinical and dermatohistopathological phenotypes. However, the underlying pathomechanisms remain largely unknown, with limited studies pointing to a delayed-type III/IV hypersensitivity reaction. In the present study, we aimed to gain new insights into the pathogenesis of the two most common panniculitis subtypes, erythema nodosum (EN) and erythema induratum (EI), by exploring their cellular and molecular immune patterns. We analyzed deep lesional skin biopsies from EN and EI patients (n=16 per group) and healthy controls (n=6) using imaging mass cytometry (IMC) to map the leukocytic infiltrate. The IMC analysis revealed distinct cellular profiles for EN and EI. In both conditions, macrophages were the predominant immune cell type, exhibiting a shift towards an M1 phenotype compared to healthy controls. In EI, the M1 macrophages were particularly prominent and were noted to cluster with activated CD8+ T cells. Conversely, EN showed fewer inflammatory features and a larger B cell population. These cellular changes were supported by an overall strong type 1 immune signature on the mRNA level in both EN and EI. This was evidenced by the upregulation of NLR-, NFkB-, and inflammasome-signaling-pathway genes compared to healthy controls. The type 1 signature was more pronounced in EI than in EN. These findings challenge the current understanding of panniculitis. They point towards a key role of M1 macrophages in mediating both innate and adaptive immune responses in panniculitis.

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Potassium Iodide for Cutaneous Inflammatory Disorders: A Monocentric, Retrospective Study

Cited by 15 publications

References 25 publications

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Granuloma Annulare: An Updated Review of Epidemiology, Pathogenesis, and Treatment Options

Treatment options for necrobiosis lipoidica: a systematic review

Spatial mapping of subcutaneous adipose tissue microenviounment in panniculitis: Unveiling novel immune signatures

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