Potassium Losing Pyelonephritis

Gerstein, Alan R.

doi:10.1001/archinte.1969.00300110057010

Cited by 7 publications

(1 citation statement)

References 12 publications

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“…4). Renal day in the presence of potassium depletion sufficient to normal potassium intake, and a greater than normal inproduce hypokalemia (14,(31)(32)(33)(34)(35). Because in adult sub-take will be required to correct potassium depletion and jects dietary potassium usually exceeds 50 mEq per day maintain normokalemia.…”

Section: Methodsmentioning

confidence: 99%

Renal potassium wasting in renal tubular acidosis (RTA)

Sebastián¹,

McSherry²,

Morris³

1971

J. Clin. Invest.

127

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A B S T R A C T In two patients with classic renal tubular acidosis (RTA) and in two patients with RTA associated with the Fanconi syndrome, renal potassium wasting persisted despite sustained correction of acidosis:(a) during moderate degrees of hypokalemia, daily urinary excretion of potassium exceeded 80 mEq in each patient; (b) during more severe degrees of hypokalemia, daily urinary excretion of potassium exceeded 40 mEq in two patients and 100 mEq in another. These urinary excretion rates of potassium are more than twice those observed in potassium-depleted normal subjects with even minimal degrees of hypokalemia. The persistence of renal potassium wasting may have resulted in part from hyperaldosteronism, since urinary aldosterone was frankly increased in two patients and was probably abnormally high in the others relative to the degree of their potassium depletion. The hyperaldosteronism persisted despite sustained correction of acidosis, a normal sodium intake, and no reduction in measured plasma volume, and was not associated with hypertension; its cause was not defined. In the two patients with classic RTA, neither renal potassium wasting nor hyperaldosteronism could be explained as a consequence of a gradient restriction on renal H' -Na' exchange because the urinary pH remained greater than, or approximately equal to, the normal arterial pH or considerably greater than the minimal urinary pH attained during acidosis. The findings provide no support for the traditional view that renal potassium wasting in either classic RTA or RTA

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Section: Methodsmentioning

confidence: 99%

Renal potassium wasting in renal tubular acidosis (RTA)

Sebastián¹,

McSherry²,

Morris³

1971

J. Clin. Invest.

127

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Management of Potassium Problems During Long-Term Diuretic Therapy

Kosman¹

1974

JAMA

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Liquid and Solid Potassium Chloride: Bioavailability and Safety

et al. 1984

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Studies have suggested that microencapsulated preparations of potassium chloride may pose less risk to the upper gastrointestinal mucosa than the currently available wax-matrix preparations. Based on our own clinical experience and data available from the literature, we have concluded that (1) liquid and slow-release preparations of potassium chloride are safe and effective when used appropriately and (2) at present there is no conclusive evidence to suggest that lesions of the upper gastrointestinal tract are more prevalent with one slow-release preparation than with another.

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Potassium Losing Pyelonephritis

Cited by 7 publications

References 12 publications

Renal potassium wasting in renal tubular acidosis (RTA)

Renal potassium wasting in renal tubular acidosis (RTA)

Management of Potassium Problems During Long-Term Diuretic Therapy

Liquid and Solid Potassium Chloride: Bioavailability and Safety

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