Potassium Nitrate in Heart Failure With Preserved Ejection Fraction
Payman Zamani,
Sanjiv J. Shah,
Jordana B. Cohen
et al.
Abstract:ImportanceNitric oxide deficiency may contribute to exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). Prior pilot studies have shown improvements in exercise tolerance with single-dose and short-term inorganic nitrate administration.ObjectiveTo assess the impact of chronic inorganic nitrate administration on exercise tolerance in a larger trial of participants with HFpEF.Design, Setting, and ParticipantsThis multicenter randomized double-blinded crossover trial was c… Show more
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