Potato tuber proteins efficiently inhibit human faecal proteolytic activity: implications for treatment of peri‐anal dermatitis

Embden, J. G. H. Ruseler-Van; Lieshout, L. M. C. Van; Smits, Sam; Kessel, I. Van; Laman, Jon D.

doi:10.1111/j.1365-2362.2004.01330.x

Cited by 49 publications

(38 citation statements)

References 28 publications

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“…Therefore, it is rather straightforward that the exposure of the skin to a mixture of urine and feces contributes to an increase in the pH in the diaper area to more alkaline values (>7). This increase in turn leads to an increased activity of fecal proteases, lipases, and ureases, all of which are highly irritating to the skin . An increased activity of fecal lipases and proteases is also present, owing to an acceleration of gastrointestinal transit .…”

Section: Etiology and Pathophysiology Of Diaper Dermatitismentioning

confidence: 99%

Diagnosis and management of diaper dermatitis in infants with emphasis on skin microbiota in the diaper area

et al. 2017

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Diaper dermatitis is the most common inflammatory skin eruption within the diaper area in infants and toddlers. Although it rarely causes problems for prolonged periods of time, it causes considerable distress for both infants and parents. Diapered skin is exposed to friction, excessive hydration, varying pH, and is in constant contact with urine and feces, both of which are highly irritant to the skin. The three most common types of diaper dermatitis include chaffing dermatitis, irritant contact dermatitis, and diaper candidiasis. However, a variety of other skin conditions may manifest in the diaper area. Candida albicans and Staphylococcus aureus are most frequently isolated from the affected area and are thought to have a predominant role in diaper dermatitis. The review includes an overview of the epidemiology, etiology, and common skin microbiota in the diaper area. State-of-the-art strategies for diagnosis, management, and prevention of diaper dermatitis are also included. Appropriate skin care can help in the prevention of diaper dermatitis and can aid the reparation of the skin. This review discusses common causes, skin microbiota within the diapered area, differential diagnosis, and finally possible prevention and treatment recommendations. Recent findings have proven that the key to efficient eradication of irritant diaper dermatitis lies in its prevention.

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Section: Etiology and Pathophysiology Of Diaper Dermatitismentioning

confidence: 99%

Diagnosis and management of diaper dermatitis in infants with emphasis on skin microbiota in the diaper area

et al. 2017

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“…Several potentially nontoxic protease inhibitors, mostly of bacterial or plant origin, have been purified from barley seeds, cabbage leaves, and Streptomyces and are commercially available for prevention of protease-induced perianal dermatitis [59]. Because potato tuber proteins (peptides) efficiently inhibit human fecal proteases, they could also be useful for the treatment of peri-anal dermatitis [59]. …”

Section: Protease Inhibitors With Antimicrobial Activities From Variomentioning

confidence: 99%

Protease Inhibitors from Plants with Antimicrobial Activity

Kim

Park

Hwang

et al. 2009

IJMS

206

137

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Antimicrobial proteins (peptides) are known to play important roles in the innate host defense mechanisms of most living organisms, including plants, insects, amphibians and mammals. They are also known to possess potent antibiotic activity against bacteria, fungi, and even certain viruses. Recently, the rapid emergence of microbial pathogens that are resistant to currently available antibiotics has triggered considerable interest in the isolation and investigation of the mode of action of antimicrobial proteins (peptides). Plants produce a variety of proteins (peptides) that are involved in the defense against pathogens and invading organisms, including ribosome-inactivating proteins, lectins, protease inhibitors and antifungal peptides (proteins). Specially, the protease inhibitors can inhibit aspartic, serine and cysteine proteinases. Increased levels of trypsin and chymotrypsin inhibitors correlated with the plants resistance to the pathogen. Usually, the purification of antimicrobial proteins (peptides) with protease inhibitor activity was accomplished by salt-extraction, ultrafiltration and C18 reverse phase chromatography, successfully. We discuss the relation between antimicrobial and anti-protease activity in this review. Protease inhibitors from plants potently inhibited the growth of a variety of pathogenic bacterial and fungal strains and are therefore excellent candidates for use as the lead compounds for the development of novel antimicrobial agents.

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“…They are thus mainly considered useful as antinutritional agents. Potato PIs have also proven effects on skin diseases [8], and they may have the ability to lower blood pressure [9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Concentration and Separation of Active Proteins from Potato Industry Waste Based on Low-Temperature Evaporation and Ethanol Precipitation

et al. 2017

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Purpose. Potato fruit juice, a residue of starch industry, contains up to 2.5% [w/w] of proteins that are potentially valuable raw-materials of food, cosmetic, and pharma industries. The recovery of protein from the potato fruit juice is limited by the lack of industrially feasible concentration and separation technologies. The present research thus aimed at development of such process for the separation of active protease inhibitors from potato fruit juice. Methods. Low temperature mechanical vapor recompression evaporation was applied for concentration of potato fruit juice followed by ethanol precipitation for recovery of active proteins. The effects of precipitation temperature and precipitative agents were investigated employing response surface modeling methodology. Results. Concentration of potato fruit juice by evaporation was successful without loss of trypsin inhibition activity. Precipitation using 6.5 M ethanol at low temperature (0–+4°C) was found suitable for the recovery of active protease inhibitors from the concentrate. Piloting at starch industry yielded 50% of total proteins, with a high quantity of active protease inhibitors and a minor inclusion of other proteins. Conclusion. Concentration by low-temperature evaporation, followed by ethanol precipitation of protease inhibitors at optimized temperature, is an attractive option for valorization of potato fruit juice.

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Potato tuber proteins efficiently inhibit human faecal proteolytic activity: implications for treatment of peri‐anal dermatitis

Cited by 49 publications

References 28 publications

Diagnosis and management of diaper dermatitis in infants with emphasis on skin microbiota in the diaper area

Diagnosis and management of diaper dermatitis in infants with emphasis on skin microbiota in the diaper area

Protease Inhibitors from Plants with Antimicrobial Activity

Concentration and Separation of Active Proteins from Potato Industry Waste Based on Low-Temperature Evaporation and Ethanol Precipitation

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