Potency Evaluation of Recombinant Human Erythropoietin in Brazil: Assessment of Reproducibility Using a Practical Approach

Abstract

In this study, we compared the results of potency determination of recombinant human erythropoietin (rhEPO

3r s applied to in vivo biological activity of recombinant human erythropoietin assay

“…does not recommend any specific method for blood extraction. However, the vast majority of publications regarding this assay perform blood extraction via retrobulbar bleeding [13][14][15][16] . In a recent study, retro orbital sinus puncture resulted in reduced activity and increased anxiety in mice, whereas submandibular bleeding had the lower adverse effects on welfare parameters 17 .…”