Potency evaluation of tissue engineered and regenerative medicine products

Guthrie, Kelly; Bruce, A. Gregory; Sangha, Namrata; Rivera, Elias; Basu, Joydeep

doi:10.1016/j.tibtech.2013.05.007

Cited by 34 publications

(27 citation statements)

References 39 publications

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“…This emerging interdisciplinary research area provides a platform on which to establish a tangible translational pipeline, such as by modifying chemical signals to responsive cells and by creating manmade tissues or organs using mechanical and adhesive molecules as raw building blocks [39]. It is plausible that in the near future, exciting developments that rise to the demands and realities of the marketplace will inform us how these goals can be realized at the clinical level and how even relatively practical and simple regenerative solutions may render considerable functional benefits [16,38,700]. …”

Section: Future Directions and Outlookmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

963

513

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Biomaterials have played an increasingly prominent role in the success of biomedical devices and in the development of tissue engineering, which seeks to unlock the regenerative potential innate to human tissues/organs in a state of deterioration and to restore or reestablish normal bodily function. Advances in our understanding of regenerative biomaterials and their roles in new tissue formation can potentially open a new frontier in the fast-growing field of regenerative medicine. Taking inspiration from the role and multi-component construction of native extracellular matrices (ECMs) for cell accommodation, the synthetic biomaterials produced today routinely incorporate biologically active components to define an artificial in vivo milieu with complex and dynamic interactions that foster and regulate stem cells, similar to the events occurring in a natural cellular microenvironment. The range and degree of biomaterial sophistication have also dramatically increased as more knowledge has accumulated through materials science, matrix biology and tissue engineering. However, achieving clinical translation and commercial success requires regenerative biomaterials to be not only efficacious and safe but also cost-effective and convenient for use and production. Utilizing biomaterials of human origin as building blocks for therapeutic purposes has provided a facilitated approach that closely mimics the critical aspects of natural tissue with regard to its physical and chemical properties for the orchestration of wound healing and tissue regeneration. In addition to directly using tissue transfers and transplants for repair, new applications of human-derived biomaterials are now focusing on the use of naturally occurring biomacromolecules, decellularized ECM scaffolds and autologous preparations rich in growth factors/non-expanded stem cells to either target acceleration/magnification of the body's own repair capacity or use nature's paradigms to create new tissues for restoration. In particular, there is increasing interest in separating ECMs into simplified functional domains and/or biopolymeric assemblies so that these components/constituents can be discretely exploited and manipulated for the production of bioscaffolds and new biomimetic biomaterials. Here, following an overview of tissue auto-/allo-transplantation, we discuss the recent trends and advances as well as the challenges and future directions in the evolution and application of human-derived biomaterials for reconstructive surgery and tissue engineering. In particular, we focus on an exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications and to provide inspiration for the design of future biomaterials.

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Section: Future Directions and Outlookmentioning

confidence: 99%

Advancing biomaterials of human origin for tissue engineering

Chen

Liu

2016

Progress in Polymer Science

963

513

View full text Add to dashboard Cite

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“…It contributes to the regeneration of native tissues and organs by niche-specific directed differentiation towards defined developmental lineages by signaling cues derived from the surrounding tissue or organ parenchyma [39]. Stem cells have been preferentially used as a crucial source for cell therapy.…”

Section: Bacterial Cellulose For Tissue Engineering and Regenerative mentioning

confidence: 99%

Bacterial Cellulose

Barud

Gutierrez²,

Lustri

et al. 2016

Biomaterials From Nature for Advanced Devices and Therapies

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“…This multifactorial, complex mechanism of action requires the development of potency tests for PRP therapies as a key step to strengthen its efficacy, similar to those that can be developed for cellular therapies [7] or tissue engineering products [8].…”

Section: Science and Societymentioning

confidence: 99%