Potent and Synergistic Extract Combinations from Terminalia Catappa, Terminalia Mantaly and Monodora tenuifolia Against Pathogenic Yeasts

Ngouana, Thierry Kammalac; Mbouna, Cedric Derick Jiatsa; Toghueo, Rufin Marie Kouipou; Tchuenmogne, Marthe Aimée Tchuente; Zeuko’o, Elisabeth Menkem; Ngouana, Vincent; Mallié, M.; Bertout, Sébastien; Boyom, Fabrice Fekam

doi:10.3390/medicines2030220

Cited by 21 publications

(16 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subfraction combinations of Terminalia catappa, Terminalia mantaly, and Monodora tenuifolia showed synergistic interactions against C. albicans, C. glabrata, C. parapsilosis, and C. neoformans isolates. Synergistic combination between M. tenuifolia and T. mantaly subfractions also showed fungicidal effects against most tested strains [168].…”

Section: Synergistic Action Between Phytochemicals and Antifungalsmentioning

confidence: 86%

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Monteiro¹,

Santos²

2020

Phytochemicals in Human Health

View full text Add to dashboard Cite

The rate of fungal infections is increasing rapidly, and pathogenesis of their species is poorly understood. Among fungi, Candida species are a major cause of morbidity and mortality worldwide and thus represent a serious threat to public health. In addition, Cryptococcus spp. are yeasts responsible for serious lung infections and meningitis. Polyenes, fluoropyrimidines, echinocandins, and azoles are used as commercial antifungal agents to treat fungal infections. However, the presence of intrinsic and developed resistance against azole antifungals has been extensively documented. The re-emergence of classical fungal diseases has occurred because of the increment of the antifungal resistance phenomenon. In this way, the development of new satisfactory therapy for fungal diseases persists as a major challenge of present-day medicine. The urgent need includes the development of alternative drugs that are more efficient and tolerant than those traditional already in use. The identification of new substances with potential antifungal effect at low concentrations or in combination is also a possibility. This chapter briefly examines the infections caused by Candida and Cryptococcus species and focuses on describing some of the promising alternative molecules and/or substances that could be used as antifungal agents, their mechanisms of action, and their use in combination with traditional drugs.

show abstract

Section: Synergistic Action Between Phytochemicals and Antifungalsmentioning

confidence: 86%

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Monteiro¹,

Santos²

2020

Phytochemicals in Human Health

View full text Add to dashboard Cite

show abstract

“…Numerous scientific studies have explored the antimicrobial, antiprotozoal, antidiarrheal, anti-inflammatory, antitumor and wound healing activities; which can be attributed to phytochemicals present in the plant [ 1 ]. A survey of the literature has revealed that the Terminalia genus, TM included; possesses a variety of bioactive phytochemical constituents, such as tannins, pentacyclic triterpenes, glycoside derivatives, flavonoids and phenolic compounds [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

et al. 2020

View full text Add to dashboard Cite

Scientists have demonstrated the potential of plant materials as ‘green’ reducing and stabilizing agents for the synthesis of gold nanoparticles (AuNPs) and opened new ecofriendly horizons to develop effective and less harmful treatment strategies. The current study demonstrated the use of Terminalia mantaly (TM) extracts to synthesize AuNPs with enhanced cytotoxic effects. The TM-AuNPs were synthesized at 25 and 70 °C using water (WTM) and methanolic (MTM) extracts of the leaf, root and stem/bark parts of the plant. The TM-AuNPs were characterized using UV–visible spectrophotometry, dynamic light scattering (DLS), transmission electron microscopy, energy dispersive X-ray (EDX), selection area electron diffraction (SAED) and Fourier transform infrared (FTIR) spectroscopy. Majority of the TM-AuNPs were spherical with a mean diameter between 22.5 and 43 nm and were also crystalline in nature. The cytotoxic effects of TM-AuNPs were investigated in cancer (Caco-2, MCF-7 and HepG2) and non-cancer (KMST-6) cell lines using the MTT assay. While the plant extracts showed some cytotoxicity towards the cancer cells, some of the TM-AuNPs were even more toxic to the cells. The IC50 values (concentrations of the AuNPs that inhibited 50% cell growth) as low as 0.18 µg/mL were found for TM-AuNPs synthesized using the root extract of the plant. Moreover, some of the TM-AuNPs demonstrated selective toxicity towards specific cancer cell types. The study demonstrates the potential of TM extracts to produce AuNPs and describe the optimal conditions for AuNPs using TM extracts. The toxicity of some the TM-AuNPs can possibly be explored in the future as an antitumor treatment.

show abstract

“…In Cameroon, extracts from medicinal plants such as Terminalia mantaly (Combretaceae) are widely used by traditional healers to control diverse infections or associated symptoms, including but not limited to dysentery, gastroenteritis, hypertension, diabetes, and oral, dental, cutaneous and genital affections [ 8 ]. Previous studies on the extracts of this plant have showed antibacterial and antifungal properties, but their chemical compositions have not yet been determined [ 9 ]. However, phytochemical studies of other species of the genus Terminalia have reported the presence of flavonoids, terpenoids and their glycosides derivatives, tannins, flavonones and chalcones [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background: Pathogenic yeasts resistance to current drugs emphasizes the need for new, safe, and cost-effective drugs. Also, new inhibitors are needed to control the effects of enzymes that are implicated in metabolic dysfunctions such as cancer, obesity, and epilepsy. Methods: The anti-yeast extract from Terminalia mantaly (Combretaceae) was fractionated and the structures of the isolated compounds established by means of spectroscopic analysis and comparison with literature data. Activity was assessed against Candida albicans, C. parapsilosis and C. krusei using the microdilution method, and against four enzymes of metabolic significance: glucose-6-phosphate dehydrogenase, human erythrocyte carbonic anhydrase I and II, and glutathione S-transferase. Results: Seven compounds, 3,3′-di-O-methylellagic acid 4′-O-α-rhamnopyranoside; 3-O-methylellagic acid; arjungenin or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid; arjunglucoside or 2,3,19,23-tetrahydroxyolean-12-en-28-oïc acid glucopyranoside; 2α,3α,24-trihydroxyolean-11,13(18)-dien-28-oïc acid; stigmasterol; and stigmasterol 3-O-β-d-glucopyranoside were isolated from the extract. Among those, 3,3′-di-O-methylellagic acid 4′-O-α-rhamnopyranoside, 3-O-methylellagic acid, and arjunglucoside showed anti-yeast activity comparable to that of reference fluconazole with minimal inhibitory concentrations (MIC) below 32 µg/mL. Besides, Arjunglucoside potently inhibited the tested enzymes with 50% inhibitory concentrations (IC50) below 4 µM and inhibitory constant (Ki) <3 µM. Conclusions: The results achieved indicate that further SAR studies will likely identify potent hit derivatives that should subsequently enter the drug development pipeline.

show abstract

Potent and Synergistic Extract Combinations from Terminalia Catappa, Terminalia Mantaly and Monodora tenuifolia Against Pathogenic Yeasts

Cited by 21 publications

References 29 publications

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Phytochemicals and Their Antifungal Potential against Pathogenic Yeasts

Synthesis of Biogenic Gold Nanoparticles from Terminalia mantaly Extracts and the Evaluation of Their In Vitro Cytotoxic Effects in Cancer Cells

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance

Contact Info

Product

Resources

About