Potent CTL Induction by a Whole Cell Pertussis Vaccine in Anti‐Tumor Peptide Immunotherapy

Yano, Arisa; Komatsu, Toshihiro; Ishibashi, Masayoshi; Udaka, Keiko

doi:10.1111/j.1348-0421.2007.tb03957.x

Cited by 13 publications

(10 citation statements)

References 61 publications

(67 reference statements)

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“…Studies on antibody seroprevalence and cell-mediated immunity (CMI) in our adolescent vaccinees also pointed to an influence of subclinical natural boosters on pertussis specific immunity [11]. This hypothesis is in line with data from Yano et al, who describe that in adults who were once primed for a Th1-biased immune response by wcP vaccine or by natural pertussis infection, the pertussis specific T cell pool maintains their Th1-biased responses even when boosted with aP vaccine [28].…”

Section: Discussionsupporting

confidence: 86%

Acellular Pertussis Booster in Adolescents Induces Th1 and Memory CD8+ T Cell Immune Response

et al. 2011

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In a number of countries, whole cell pertussis vaccines (wcP) were replaced by acellular vaccines (aP) due to an improved reactogenicity profile. Pertussis immunization leads to specific antibody production with the help of CD4+ T cells. In earlier studies in infants and young children, wcP vaccines selectively induced a Th1 dominated immune response, whereas aP vaccines led to a Th2 biased response. To obtain data on Th1 or Th2 dominance of the immune response in adolescents receiving an aP booster immunization after a wcP or aP primary immunization, we analyzed the concentration of Th1 (IL-2, TNF-α, INF-γ) and Th2 (IL-4, IL-5, IL-10) cytokines in supernatants of lymphocyte cultures specifically stimulated with pertussis antigens. We also investigated the presence of cytotoxic T cell responses against the facultative intracellular bacterium Bordetella pertussis by quantifying pertussis-specific CD8+ T cell activation following the aP booster immunization. Here we show that the adolescent aP booster vaccination predominantly leads to a Th1 immune response based on IFNgamma secretion upon stimulation with pertussis antigen, irrespective of a prior whole cell or acellular primary vaccination. The vaccination also induces an increase in peripheral CD8+CD69+ activated pertussis-specific memory T cells four weeks after vaccination. The Th1 bias of this immune response could play a role for the decreased local reactogenicity of this adolescent aP booster immunization when compared to the preceding childhood acellular pertussis booster. Pertussis-specific CD8+ memory T cells may contribute to protection against clinical pertussis.

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Section: Discussionsupporting

confidence: 86%

Acellular Pertussis Booster in Adolescents Induces Th1 and Memory CD8+ T Cell Immune Response

et al. 2011

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“…No protective role of CD8 + T cells was demonstrated in B. pertussis -infected mice so far [49–51]. However, whole cell pertussis vaccine has been used in a mouse model as adjuvant to induce a cytotoxic activity against a tumor peptide [52]. It is therefore possible that the FHA-induced IFN- γ production by CD8 + lymphocytes is accompanied by a cytotoxic function of these cells.…”

Section: Discussionmentioning

confidence: 99%

BothCD4+andCD8+Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin fromBordetella pertussisin Infants, Children, and Adults

Dirix

Verscheure

Vermeulen

et al. 2012

Clinical and Developmental Immunology

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Infant CD4+T-cell responses to bacterial infections or vaccines have been extensively studied, whereas studies on CD8+T-cell responses focused mainly on viral and intracellular parasite infections. Here we investigated CD8+T-cell responses uponBordetella pertussisinfection in infants, children, and adults and pertussis vaccination in infants. Filamentous hemagglutinin-specific IFN-γsecretion by circulating lymphocytes was blocked by anti-MHC-I or -MHC-II antibodies, suggesting that CD4+and CD8+T lymphocytes are involved in IFN-γproduction. Flow cytometry analyses confirmed that both cell types synthesized antigen-specific IFN-γ, although CD4+lymphocytes were the major source of this cytokine. IFN-γsynthesis by CD8+cells was CD4+T cell dependent, as evidenced by selective depletion experiments. Furthermore, IFN-γsynthesis by CD4+cells was sometimes inhibited by CD8+lymphocytes, suggesting the presence of CD8+regulatory T cells. The role of this dual IFN-γsecretion by CD4+and CD8+T lymphocytes in pertussis remains to be investigated.

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“…Such responses are usually induced by cellular vaccines, as the case of whole cell pertussis vaccine (wP) [32], [33], [34], [35]. In addition to the high efficacy of wP against whooping cough, numerous works have described its efficacy as adjuvant when administered in combination with different antigens [36], [37]. Cellular pertussis vaccines have sometimes been associated with serious side effects in children.…”

Section: Introductionmentioning

confidence: 99%

Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice

et al. 2010

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Streptococcus pneumoniae is the leading cause of respiratory acute infections around the world. In Latin America, approximately 20,000 children under 5 years of age die of pneumococcal diseases annually. Pneumococcal surface protein A (PspA) is among the best-characterized pneumococcal antigens that confer protection in animal models of pneumococcal infections and, as such, is a good alternative for the currently available conjugated vaccines. Efficient immune responses directed to PspA in animal models have already been described. Nevertheless, few low cost adjuvants for a subunit pneumococcal vaccine have been proposed to date. Here, we have tested the adjuvant properties of the whole cell Bordetella pertussis vaccine (wP) that is currently part of the DTP (diphtheria-tetanus-pertussis) vaccine administrated to children in several countries, as an adjuvant to PspA. Nasal immunization of BALB/c mice with a combination of PspA5 and wP or wPlow – a new generation vaccine that contains low levels of B. pertussis LPS – conferred protection against a respiratory lethal challenge with S. pneumoniae. Both PspA5-wP and PspA5-wPlow vaccines induced high levels of systemic and mucosal antibodies against PspA5, with similar profile, indicating no essential requirement for B. pertussis LPS in the adjuvant properties of wP. Accordingly, nasal immunization of C3H/HeJ mice with PspA5-wP conferred protection against the pneumococcal challenge, thus ruling out a role for TLR4 responses in the adjuvant activity and the protection mechanisms triggered by the vaccines. The high levels of anti-PspA5 antibodies correlated with increased cross-reactivity against PspAs from different clades and also reflected in cross-protection. In addition, passive immunization experiments indicated that antibodies played an important role in protection in this model. Finally, subcutaneous immunization with a combination of PspA5 with DTPlow protected mice against challenge with two different pneumococcal strains, opening the possibility for the development of a combined infant vaccine composed of DTP and PspA.

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Potent CTL Induction by a Whole Cell Pertussis Vaccine in Anti‐Tumor Peptide Immunotherapy

Cited by 13 publications

References 61 publications

Acellular Pertussis Booster in Adolescents Induces Th1 and Memory CD8+ T Cell Immune Response

Acellular Pertussis Booster in Adolescents Induces Th1 and Memory CD8+ T Cell Immune Response

BothCD4+andCD8+Lymphocytes Participate in the IFN-γ Response to Filamentous Hemagglutinin fromBordetella pertussisin Infants, Children, and Adults

Combination of Pneumococcal Surface Protein A (PspA) with Whole Cell Pertussis Vaccine Increases Protection Against Pneumococcal Challenge in Mice

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