Potent new cell adhesion inhibitory compounds from the root of Trichilia rubra

Schisandrene, a Dibenzocyclooctadiene Lignan from Schisandra chinensis: Structure−Antioxidant Activity Relationships of Dibenzocyclooctadiene Lignans

“…The XTT (3′-1[(phenylamino)-carbonyl]-3,4-tetrazoliumbis(4-methoxy-6-nitro)benzenesulfonic acid hydrate) assay was performed as reported earlier. 29 The compounds were also tested for their in vitro cytotoxicity against a panel of human solid tumor cells (SK-MEL malignant, melanoma; KB epidermal carcinoma, oral; BT-549 ductal carcinoma, breast; and SK-OV-3 ovary carcinoma) as well as noncancerous kidney epithelial cells (LLC-PK1) according to a modification of the procedure of Borenfreund et al 30 Briefly, the cells were washed with saline followed by incubation for 3 h with a solution of neutral red. The cells were washed again to remove extracellular dye.…”

Analysis of mexicanolide‐ and phragmalin‐type limonoids from Heynea trijuga using high‐performance liquid chromatography/electrospray tandem mass spectrometry

“…These compounds have attracted attention in the fields of nutrition and medicine due to their diverse structures and significant biological activities. The biological effects of limonoids include insect antifeedant and growth‐regulating activities, antimicrobial activity, potent cell adhesion inhibitory effects, antimalarial activity against Plasmodium falciparum , anticancer activities, and antioxidant activity . Phragmalin‐ and mexicanolide‐type limonoids show moderate cytotoxicity against HL‐60 cells and insecticidal activity .…”

Naturally occurring cell adhesion inhibitors

“…The extract from the root of Trichilia rubra (Meliaceae) was identified as having potent inhibitory activity in a bioassay for LFA-l/ICAM-I-mediated adhesion of JY and HeLa cells [ 24 ]. A series of seco -limonoids ( 16 – 22 ) with uncommon hemi ortho ester A-rings, was isolated.…”