Potential allelopatic effects of stilbenoids and flavonoids from leaves of Carex distachya Desf.

Fiorentino, Antonio; D’Abrosca, Brigida; Pacifico, Severina; Izzo, Angelina; Letizia, Marianna; Esposito, Assunta; Monaco, Pietro

doi:10.1016/j.bse.2008.07.002

Cited by 41 publications

(34 citation statements)

References 21 publications

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“…These compounds inhibit fungal growth by interfering with microtubule assembly (Woods et al, 1995), disrupting plasma membranes, and uncoupling electron transport in fungal spores and germ tubes (Pezet and Pont, 1990). Stilbenes have also been shown to protect plants against oxidative stress (Rosemann et al, 1991;Adrian et al, 1996;He et al, 2008), to deter herbivores (Torres et al, 2003), and to inhibit the growth of competing plants (Fiorentino et al, 2008). However, their functions in conifers are poorly studied despite their abundance in widespread genera, such as spruce and pine.…”

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confidence: 99%

Biosynthesis of the Major Tetrahydroxystilbenes in Spruce, Astringin and Isorhapontin, Proceeds via Resveratrol and Is Enhanced by Fungal Infection

et al. 2011

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V6T 1Z4 (S.G.R., J.B.)Stilbenes are dibenzyl polyphenolic compounds produced in several unrelated plant families that appear to protect against various biotic and abiotic stresses. Stilbene biosynthesis has been well described in economically important plants, such as grape (Vitis vinifera), peanut (Arachis hypogaea), and pine (Pinus species). However, very little is known about the biosynthesis and ecological role of stilbenes in spruce (Picea), an important gymnosperm tree genus in temperate and boreal forests. To investigate the biosynthesis of stilbenes in spruce, we identified two similar stilbene synthase (STS) genes in Norway spruce (Picea abies), PaSTS1 and PaSTS2, which had orthologs with high sequence identity in sitka (Picea sitchensis) and white (Picea glauca) spruce. Despite the conservation of STS sequences in these three spruce species, they differed substantially from angiosperm STSs. Several types of in vitro and in vivo assays revealed that the P. abies STSs catalyze the condensation of p-coumaroyl-coenzyme A and three molecules of malonyl-coenzyme A to yield the trihydroxystilbene resveratrol but do not directly form the dominant spruce stilbenes, which are tetrahydroxylated. However, in transgenic Norway spruce overexpressing PaSTS1, significantly higher amounts of the tetrahydroxystilbene glycosides, astringin and isorhapontin, were produced. This result suggests that the first step of stilbene biosynthesis in spruce is the formation of resveratrol, which is further modified by hydroxylation, O-methylation, and O-glucosylation to yield astringin and isorhapontin. Inoculating spruce with fungal mycelium increased STS transcript abundance and tetrahydroxystilbene glycoside production. Extracts from STSoverexpressing lines significantly inhibited fungal growth in vitro compared with extracts from control lines, suggesting that spruce stilbenes have a role in antifungal defense.

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confidence: 99%

Biosynthesis of the Major Tetrahydroxystilbenes in Spruce, Astringin and Isorhapontin, Proceeds via Resveratrol and Is Enhanced by Fungal Infection

et al. 2011

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“…Flavonoids, stilbene derivatives, phenolic acids and fatty acids are the most common compounds identified in the genus [22]. There are a lot of questions related to the taxonomy of this genus caused by the difficulties in the species recognition due to morphological similarity of species, as well as the lack of habitat preference of the individual species.…”

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confidence: 99%

The start-to-end chemometric image processing of 2D thin-layer videoscans

Komsta

Cieśla

Bogucka‐Kocka

et al. 2011

Journal of Chromatography A

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“…1) [Zhou and Ibrahim, 2010] is a member of the flavone subgroup of flavonoids, found in rice, oats, barley, and wheat [Saleh et al, 1988; Kong et al, 2007], that possesses anti‐oxidant activity [Yong et al, 2002]. Although its physiological function in plants is not well defined, it is thought to be produced during times of environmental stress or following pathogenic attack [Park et al, 2007] in order to exert potential allelopathic effects [Fiorentino et al, 2008].…”

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Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways

Seki

Toh

Kawaguchi

et al. 2012

J of Cellular Biochemistry

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4',5,7-Trihydroxy-3',5'-dimethoxyflavone (Tricin), a naturally occurring flavone, has anti-inflammatory potential and exhibits diverse biological activities including antigrowth activity in several human cancer cell lines and cancer chemopreventive effects in the gastrointestinal tract of mice. The present study aimed to investigate the biological actions of tricin on hepatic stellate cells (HSCs) in vitro, exploring its potential as a treatment of liver fibrosis, since HSC proliferation is closely related to the progression of hepatic fibrogenesis in chronic liver diseases leading to irreversible liver cirrhosis and hepatocellular carcinoma. Tricin inhibited platelet-derived growth factor (PDGF)-BB-induced cell proliferation by blocking cell cycle progression and cell migration in the human HSC line LI90 and culture-activated HSCs. It also reduced the phosphorylation of PDGF receptor β and the downstream signaling molecules ERK1/2 and Akt, which might be due to its tyrosine kinase inhibitor properties rather than inhibition of the direct binding between PDGF-BB and its receptor. Our findings suggest that tricin might be beneficial in HSC-targeting therapeutic or chemopreventive applications for hepatic fibrosis.

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Potential allelopatic effects of stilbenoids and flavonoids from leaves of Carex distachya Desf.

Cited by 41 publications

References 21 publications

Biosynthesis of the Major Tetrahydroxystilbenes in Spruce, Astringin and Isorhapontin, Proceeds via Resveratrol and Is Enhanced by Fungal Infection

Biosynthesis of the Major Tetrahydroxystilbenes in Spruce, Astringin and Isorhapontin, Proceeds via Resveratrol and Is Enhanced by Fungal Infection

The start-to-end chemometric image processing of 2D thin-layer videoscans

Tricin inhibits proliferation of human hepatic stellate cells in vitro by blocking tyrosine phosphorylation of PDGF receptor and its signaling pathways

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