Potential anticancer applications of the novel naringin-based ruthenium (II) complex

Garcia, John Phillip; Lakshmi, Buddolla Anantha; Kim, Sanghyo

doi:10.1007/s13205-019-1718-4

Cited by 9 publications

(6 citation statements)

References 15 publications

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“…Naringin was used to fabricate a ruthenium complex with anticancer activity. Results showed that a naringin-ruthenium (II) complex reduced cell viability and proliferation, and promoted apoptosis in A549 human lung adenocarcinoma ( Garcia et al, 2019 ). Also, treatment with naringin alone and in combination with transition metal ions [Ag (I), Y (III), and Ru (III)] reduced cell growth and viability, and enhanced apoptosis in A549 human lung adenocarcinoma.…”

Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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Background: Natural product-based cancer preventive and therapeutic entities, such as flavonoids and their derivatives, are shown to have a noticeable capability to suppress tumor formation and cancer cell growth. Naringin, a natural flavanone glycoside present in various plant species, has been indicated to modulate different signaling pathways and interact with numerous cell signaling molecules, which allows for an extensive variety of pharmacological actions, such as amelioration of inflammation, oxidative stress, metabolic syndromes, bone disorders, and cancer. The purpose of this systematic review is to present a critical and comprehensive assessment of the antitumor ability of naringin and associated molecular targets in various cancers.Methods: Studies were identified through systematic searches of Science Direct, PubMed, and Scopus as well as eligibility checks according to predefined selection criteria.Results: Eighty-seven studies were included in this systematic review. There was strong evidence for the association between treatment with naringin alone, or combined with other drugs and antitumor activity. Additionally, studies showed that naringin-metal complexes have greater anticancer effects compared to free naringin. It has been demonstrated that naringin employs multitargeted mechanisms to hamper cancer initiation, promotion, and progression through modulation of several dysregulated signaling cascades implicated in cell proliferation, autophagy, apoptosis, inflammation, angiogenesis, metastasis, and invasion.Conclusion: The results of our work show that naringin is a promising candidate for cancer prevention and treatment, and might offer substantial support for the clinical application of this phytocompound in the future. Nevertheless, further preclinical and clinical studies as well as drug delivery approaches are needed for designing novel formulations of naringin to realize the full potential of this flavonoid in cancer prevention and intervention.

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Section: Anticancer Activities Of Naringinmentioning

confidence: 99%

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

et al. 2021

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“…Amidst flavonoids, quercetin and its metal complexes have been studied in terms of DNA binding studies, in order to establish structure-activity relationships [58]. Recently, Ru [59][60][61][62][63][64][65][66], V [67,68], Zn [69], Cu [70,71], Fe [72] and La [73] complexes bearing bioactive flavonoids or related ligands have been described. This also include half-sandwich ruthenium [74][75][76][77], rhodium [74,75] and osmium [75,78] derivatives that exhibit cytotoxic activity.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Activity of Half-Sandwich Ru, Rh and Ir Complexes with Chrysin Derived Ligands: Strong Effect of the Side Chain in the Ligand and Influence of the Metal

et al. 2021

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An important challenge in the field of anticancer chemotherapy is the search for new species to overcome the resistance of standard drugs. An interesting approach is to link bioactive ligands to metal fragments. In this work, we have synthesized a set of p-cymene-Ru or cyclopentadienyl-M (M = Rh, Ir) complexes with four chrysin-derived pro-ligands with different -OR substituents at position 7 of ring A. The introduction of a piperidine ring on chrysin led to the highly cytotoxic pro-ligand HL4 and its metal complexes L4-M (SW480 and A549 cell lines, cytotoxic order: L4-Ir > L4-Ru ≈ L4-Rh). HL4 and its complexes induce apoptosis and can overcome cis-platinum resistance. However, HL4 turns out to be more cytotoxic in healthy than in tumor cells in contrast to its metal complexes which displayed higher selectivity than cisplatin towards cancer cells. All L4-M complexes interact with double stranded DNA. Nonetheless, the influence of the metal is clear because only complex L4-Ir causes DNA cleavage, through the generation of highly reactive oxygen species (1O2). This result supports the hypothesis of a potential dual mechanism consisting of two different chemical pathways: DNA binding and ROS generation. This behavior provides this complex with a great effectivity in terms of cytotoxicity.

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“…Likewise, naringin regulated the proliferation of HepG2 hepatocellular carcinoma cell line [79] . Further, naringinbased synthetic ruthenium complex showed anticancer potential against A549 human cell line without any toxicity on dermal fibroblasts [80] .…”

Section: Naringin and Cancer Cellsmentioning

confidence: 95%

Naringin: Biosynthesis and Pharmaceutical Applications

Sharma¹,

Kumar²,

Guleria³

2019

ijps

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Sharma et al.: Biosynthesis and Pharmaceutical Applications of naringinNaringin is a plant flavonoid of huge medicinal importance. It is synthesized by the phenylpropanoid pathway via seven enzyme catalysed steps from phenylalanine to prunin. The genes encoding the enzymes of phenylpropanoid pathway have been cloned and characterized. Naringin has been known to possess antioxidant, antiinflammatory and antitumer potential. Exposure to naringin in vivo and in vitro in several test animals and cell lines has been reported to demonstrate activities that could treat asthma, hyperlipidaemia, diabetes, tumour, hyperthyroidism and osteoclastogenesis. Based on the reported research of naringin on test animals, naringin could be regarded as an efficient natural remedy for the treatment of human metabolic disorders. However, detailed exploration of naringin exposure on humans needs to be studied.

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Potential anticancer applications of the novel naringin-based ruthenium (II) complex

Cited by 9 publications

References 15 publications

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies

Anticancer Activity of Half-Sandwich Ru, Rh and Ir Complexes with Chrysin Derived Ligands: Strong Effect of the Side Chain in the Ligand and Influence of the Metal

Naringin: Biosynthesis and Pharmaceutical Applications

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