Potential application of antiviral coumarin in aquaculture against IHNV infection by reducing viral adhesion to the epithelial cell surface

Liu, Lei; Shan, Li-Peng; Xue, Mingyang; Lu, Jian-Fei; Hu, Yang; Liu, Guanglu; Chen, Jiong

doi:10.1016/j.antiviral.2021.105192

Cited by 19 publications

(9 citation statements)

References 41 publications

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“…The flavonoid quercetin can inhibit herpes simplex virus type 1 (HSV-1), HSV-2, and Singapore grouper iridovirus (SGIV) infection by blocking the binding of viruses to host cells ( Hung et al, 2015 ; Liu et al, 2020b ). Small-molecule antiviral coumarin derivatives occurring in several plants show efficacy in inhibiting the life cycle of viruses, including their binding, internalization, and post-entry transport ( Liu et al, 2021 ; Song et al, 2020a , 2020b , 2021 ). In this study, TET and DHA both reduced the infectivity of SVCV, but only TET reduced infection by disturbing virus internalization.…”

Section: Discussionmentioning

confidence: 99%

Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication

Zhou¹,

Qiu²,

Hu³

et al. 2022

Zoological Research

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Spring viremia of carp virus (SVCV) is globally widespread and poses a serious threat to aquatic ecology and aquaculture due to its broad host range. To develop effective agents to control SVCV infection, we selected 16 naturally active small molecules to assess their anti-SVCV activity. Notably, dihydroartemisinin (DHA) (100 µmol/L) and (S, S)-(+)-tetrandrine (TET) (16 µmol/L) exhibited high antiviral effects in epithelioma papulosum cyprinid (EPC) cells, with inhibitory rates of 70.11% and 73.54%, respectively. The possible antiviral mechanisms were determined as follows: 1. Pre-incubation with DHA and TET decreased viral particle infectivity in fish cells, suggesting that horizontal transmission of SVCV in the aquatic environment was disrupted; 2. Although neither had an effect on viral adhesion, TET (but not DHA) interfered with SVCV entry into host cells (>80%), suggesting that TET may have an antiviral function in early viral replication. For in vivo study, both agents enhanced the survival rate of SVCV-infected zebrafish by 53.3%, significantly decreased viral load, and modulated the expression of antiviral-related genes, indicating that DHA and TET may stimulate the host innate immune response to prevent viral infection. Overall, our findings indicated that DHA and TET had positive effects on suppressing SVCV infection by affecting early-stage viral replication, thus holding great potential as immunostimulants to reduce the risk of aquatic rhabdovirus disease outbreaks.

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Section: Discussionmentioning

confidence: 99%

Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication

Zhou¹,

Qiu²,

Hu³

et al. 2022

Zoological Research

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show abstract

Section: Discussionmentioning

confidence: 99%

“…Viral life cycles begin with attachment to host cell surface receptors, cell entry, viral nucleic acid uncoating and genome replication (Chen, Hao, et al, 2018). Therefore, antiviral medications mainly inhibited viral replication through three approaches (Liu et al, 2021): (1) directly inactivating the virus, (2) blocking viral adsorption to the host cells and (3) inhibiting viral reproduction and biosynthesis. Piperine effectively inhibited LMBV in EPC cells, therefore, the potential mechanism of piperine in the process of LMBV infection was further explored.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture

Wang

Yang

Ren

et al. 2022

Journal of Fish Diseases

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Largemouth bass virus (LMBV) is a single-molecule linear doublestranded DNA (dsDNA) virus belonging to the genus ranavirus of the family Iridoviridae (Deng et al., 2011;Zhu et al., 2020). LMBV causes >60% mortality in largemouth bass and has been reported from different corners of the world (Deng et al., 2011;Woodland et al., 2002;Zhao et al., 2020). Some parts of China and the Americas, as well as parts of Europe, are affected by frequent LMBV outbreaks (Boonthai et al., 2018;Zhao et al., 2020). LMBV infection has been further expanded with the broader culture and trade of largemouth bass worldwide, thereby increasing the need for antiviral strategies against LMBV.

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“…Coumarins are the most abundant and main bioactive constituents present in of A. dahurica. They have a broad spectrum of pharmacological activities, such as anti-viral (Liu et al, 2021), anti-tumor (Banikazemi et al, 2021), antiosteoporosis (Jia et al, 2016) and effects on the cardiovascular system (Najmanova et al, 2015). To date, a total of 153 coumarins have been isolated from the root and stem of A. dahurica, include 18 simple coumarins (1-18), 93 furanocoumarins (19-111), 41 coumarins glycosides (112-147), 3 other coumarins (148-150) and 3 coumarin derivatives (151-153).…”

Section: Coumarinsmentioning

confidence: 99%

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

Zhao¹,

Feng

Wang

et al. 2022

Front. Pharmacol.

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Angelica dahurica (A. dahurica) root is a famous edible medicinal herb that has been used in China for thousands of years. To date, more than 300 chemical constituents have been discovered from A. dahurica. Among these ingredients, coumarins and volatile oils are the major active compounds. Moreover, a few other compounds have also been isolated from the root of A. dahurica, such as alkaloids, phenols, sterols, benzofurans, polyacetylenes and polysaccharides. Modern pharmacological studies demonstrated that the root of A. dahurica and its active components displayed various bioactivities such as anti-inflammation, anti-tumor, anti-oxidation, analgesic activity, antiviral and anti-microbial effects, effects on the cardiovascular system, neuroprotective function, hepatoprotective activity, effects on skin diseases and so on. Based on these studies, this review focused on the research publications of A. dahurica and aimed to summarize the advances in the traditional uses, phytochemistry and pharmacology which will provide reference for the further studies and applications of A. dahurica.

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Potential application of antiviral coumarin in aquaculture against IHNV infection by reducing viral adhesion to the epithelial cell surface

Cited by 19 publications

References 41 publications

Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication

Antiviral effects of natural small molecules on aquatic rhabdovirus by interfering with early viral replication

Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture

The Angelica dahurica: A Review of Traditional Uses, Phytochemistry and Pharmacology

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