Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders

Surico, Pier Luigi; Barone, Vincenzo; Singh, Rohan Bir; Coassin, Marco; Blanco, Tomas; Dohlman, Thomas H.; Basu, Sayan; Chauhan, Sunil K.; Dana, Reza; Di Zazzo, Antonio

doi:10.1016/j.survophthal.2024.07.008

Survey of Ophthalmology

2024

DOI: 10.1016/j.survophthal.2024.07.008

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Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders

Pier Luigi Surico,

Vincenzo Barone,

Rohan Bir Singh

et al.

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2024

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The Role of Immune Cells and Signaling Pathways in Diabetic Eye Disease: A Comprehensive Review

Barone,

Surico,

Cutrupi

et al. 2024

Biomedicines

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Diabetic eye disease (DED) encompasses a range of ocular complications arising from diabetes mellitus, including diabetic retinopathy, diabetic macular edema, diabetic keratopathy, diabetic cataract, and glaucoma. These conditions are leading causes of visual impairments and blindness, especially among working-age adults. Despite advancements in our understanding of DED, its underlying pathophysiological mechanisms remain incompletely understood. Chronic hyperglycemia, oxidative stress, inflammation, and neurodegeneration play central roles in the development and progression of DED, with immune-mediated processes increasingly recognized as key contributors. This review provides a comprehensive examination of the complex interactions between immune cells, inflammatory mediators, and signaling pathways implicated in the pathogenesis of DED. By delving in current research, this review aims to identify potential therapeutic targets, suggesting directions of research for future studies to address the immunopathological aspects of DED.

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The Role of Immune Cells and Signaling Pathways in Diabetic Eye Disease: A Comprehensive Review

Barone,

Surico,

Cutrupi

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

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Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders

Cited by 1 publication

References 150 publications

The Role of Immune Cells and Signaling Pathways in Diabetic Eye Disease: A Comprehensive Review

The Role of Immune Cells and Signaling Pathways in Diabetic Eye Disease: A Comprehensive Review

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