Sugarcane must be processed quickly after being harvested because it is a destructible commodity.Harvested cane may degrade for a variety of reasons, including exposure to microbes, mechanical or manual harvesting, cultivar, maturity, cut-to-crush interval, and storage. Due to the quick loss of sucrose and deterioration after harvest, sugarcane needs to be treated at the right time and way. The higher sugar content of mature internodes offers the perfect conditions for microbial growth, which enters the harvested stalk through wounds or cut ends. The bacteria Leuconostoc spp. is primarily responsible for these post-harvest losses, which negatively affect sugar percent. The trials were carried out to assess the e cacy of Sodium metasilicate (SMS), Benzalkonium chloride (BKC), Nisin (Lactobacteria), and Neem sources on sugarcane for reducing the post-harvest degradation losses. An investigation is underway now to reveal that foliar spray of neem cake @ 5% + dried neem leaves extract @ 5% (in heaping) is the most effective and eco-friendly substance that might be able to signi cantly enhance sugar recovery.This treatment was comparable with the chemical formulation of SMS @ 2% (3 days before harvest) + BKC @ 2000 ppm (in heaping) which might be a consequence of controlling the proliferation of Leuconostoc spp. bacterium. Likewise, the juice obtained from these treatments has a lower rate of inclination in pH, reducing sugar, total soluble solids, titrable acidity index, invertase activity, higher sucrose, and commercial cane sugars (CCS) recovery, furthermore with relatively smaller losses in cane weight. Hence, these treatments offer a signi cant potential role in reducing post-harvest deterioration losses in the sugar industry.