Potential association between rosacea and cancer: A study in a medical center in southern China

Long, Juan; Li, Ji; Yuan, Xin; Tang, Yan; Deng, Zhili; Xu, San; Zhang, Yiya; Xie, Hongfu

doi:10.1111/1346-8138.14918

Cited by 12 publications

(11 citation statements)

References 55 publications

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“…Here, we were able to show an association not only to metabolic disease, type 2 diabetes, joint problems and ophthalmologic disease, but were able to identify a strong association of rosacea and malignant melanoma as well. When viewed separately from other demographics, our Asian sub-cohort showed no association of rosacea and malignant melanoma, which is in accordance with previous data from Asian working groups 23,24 .…”

Section: Discussionsupporting

confidence: 92%

Rosacea is strongly associated with melanoma in Caucasians

von Stebut,

Mallach,

Schneider-Burrus

et al. 2024

Sci Rep

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Rosacea is often considered a cosmetic problem but is known to be associated with a variety of comorbidities. To identify such risks, we generated two age- and sex-matched real-world cohorts of 122,444 patients each with and without rosacea. In contrast to earlier studies, we found significant associations with malignant melanoma (OR 6.02, 95% CI 5.76–6.32). This association does not exist for an Asian sub-cohort, which could explain previous inconclusive or conflicting reports. Several strongly associated comorbidities like visual disturbances (ICD-10: H53–H54; OR 4.80, 4.68–4.92), metabolic disorders (E73–E79; OR 3.17, 3.11–3.22), joint problems (M25; OR 4.16, 4.08–4.25) and type 2 diabetes (E11; OR 1.62, 1.58–1.65) should be watched as a risk for rosacea patients. Rosacea is associated with some comorbidities and ethnicity may be a risk factor in melanoma development. The retrospective nature of this study and the sole use of ICD-10 code based filtering calls for future validation of our findings. Additionally, confounding factors such as skin type and previous UV exposure should be included in future studies.

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Section: Discussionsupporting

confidence: 92%

Rosacea is strongly associated with melanoma in Caucasians

von Stebut,

Mallach,

Schneider-Burrus

et al. 2024

Sci Rep

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“…Similarly, Long et al. 20 found that rosacea is significantly associated with higher incidence of breast cancer and glioma in chinese populations. Moreover, the incidence of AK and keratinocyte carcinoma in patients with rosacea was also increased.…”

Section: Disscussionmentioning

confidence: 88%

“…systemically examined the association between rosacea and cancer in US women and revealed an increased risk of thyroid cancer and basal cell carcinoma in patients with a history of rosacea. Similarly, Long et al 20 . found that rosacea is significantly associated with higher incidence of breast cancer and glioma in chinese populations.…”

Section: Disscussionmentioning

confidence: 89%

Novel insights into rosacea's role in cancer risk: A Mendelian randomization approach

Luo,

Wei

2024

Skin Research and Technology

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BackgroundChronic inflammation has been shown to promote cancer progression. Rosacea is indeed a long‐term inflammatory skin condition and had been reported to link with increased risk for several types of malignancies, but evidence for causality is lacking.ObjectivesTo systematically estimate the causal relationship between rosacea and several types of cancer, including cutaneous malignant melanoma (CMM), cutaneous squamous cell carcinoma (cSCC), basal cell carcinoma (BCC), actinic keratosis (AK), thyroid cancer, breast cancer, glioma and hepatic cancer, as well as explore the potential underlying pathogenesis.MethodsWe conducted a bidirectional two‐sample Mendelian randomization study to probe the potential causal relationships between rosacea and several types of cancer. Instrumental variables were established using genome‐wide significant single nucleotide polymorphisms associated with rosacea and cancers. The assessment of causality was carried out through multiple methods, and the robustness of the results was evaluated via sensitivity analyses.ResultsThere was no significant indication of causal effects of rosacea on CMM (pivw = 0.71), cSCC (pivw = 0.45), BCC (pivw = 0.90), AK (pivw = 0.73), thyroid cancer (pivw = 0.59), glioma (pivw = 0.15), and hepatic cancer (pivw = 0.07), but the genetic risk of rosacea was associated with an increased susceptibility to human epidermal growth factor receptor (HER)‐negative malignant neoplasm of breast (odds ratio [OR], 1.10; 95% confidence interval [CI], 1.02–1.18; pivw = 0.01). TANK (TRAF family member associated nuclear factor kappa B (NFKB) activator) was identified as a common protective gene for both rosacea (OR, 0.90; 95% CI, 0.82–0.99; pivw = 0.048) and HER‐negative malignant neoplasm of the breast (OR, 0.86; 95% CI, 0.75–0.98; pivw = 0.032), which was primarily enriched in the negative regulation of NF‐κB signal transduction and may contribute to the genetic links between rosacea and this subtype of breast cancer.ConclusionsOur findings provide suggestive evidence for causal links between rosacea and HER‐negative malignant neoplasm of the breast risk.

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“… 8 , 9 In recent years, increasing evidence has suggested a link between inflammatory skin diseases, such as psoriasis and rosacea, and various cancers, including breast cancer. 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

Causal relationship between inflammatory skin diseases and breast cancer: A bidirectional Mendelian randomization study

Yang,

Zhao

2024

Skin Research and Technology

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IntroductionPrior research has explored the relationship between inflammatory skin disorders and breast cancer (BC), yet the causality of this association remains uncertain.MethodsUtilizing a bidirectional two‐sample Mendelian randomization (MR) approach, this study aimed to elucidate the causal dynamics between various inflammatory skin conditions—namely acne, atopic dermatitis, psoriasis vulgaris, urticaria, and rosacea—and BC. Genetic variants implicated in these disorders were sourced from comprehensive genome‐wide association studies representative of European ancestry. In the forward MR, BC was posited as the exposure, while the reverse MR treated each inflammatory skin disease as the exposure. A suite of analytical methodologies, including random effects inverse variance weighted (IVW), weighted median (WME), and MR‐Egger, were employed to probe the causative links between inflammatory skin diseases and BC. Sensitivity analyses, alongside evaluations for heterogeneity and pleiotropy, were conducted to substantiate the findings.ResultsThe MR analysis revealed an increased risk of acne associated with BC (IVW: OR = 1.063, 95% CI = 1.011–1.117, p = 0.016), while noting a decreased risk of atopic dermatitis (AD) in BC patients (IVW: OR = 0.941, 95% CI = 0.886–0.999, p = 0.047). No significant associations were observed between BC and psoriasis vulgaris, urticaria, or rosacea. Conversely, reverse MR analyses detected no effect of BC on the incidence of inflammatory skin diseases. The absence of pleiotropy and the consistency of these outcomes strengthen the study's conclusions.ConclusionFindings indicate an elevated incidence of acne and a reduced incidence of AD in individuals with BC within the European population.

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Potential association between rosacea and cancer: A study in a medical center in southern China

Cited by 12 publications

References 55 publications

Rosacea is strongly associated with melanoma in Caucasians

Rosacea is strongly associated with melanoma in Caucasians

Novel insights into rosacea's role in cancer risk: A Mendelian randomization approach

Causal relationship between inflammatory skin diseases and breast cancer: A bidirectional Mendelian randomization study

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