Potential bactericidal activity of S. nux-vomica–ZnO nanocomposite against multidrug-resistant bacterial pathogens and wound-healing properties

Steffy, Katherin; Shanthi, Ganesan; Maroky, Anson S.; Selvakumar, S.

doi:10.1016/j.jtemb.2018.07.009

Cited by 17 publications

(8 citation statements)

References 48 publications

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“…Zinc oxide (ZnO) is an inorganic metal that has received much attention due to the unique physicochemical properties, biocompatibility, antibacterial activity, and selective toxicity. ZnO nanostructures have been used in various nanotechnology applications [22]. ZnO NPs can be synthesized in various ways [110].…”

Section: Resultsmentioning

confidence: 99%

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Nanotechnology‐driven advances in the treatment of diabetic wounds

Zare

Rezayi

Aryan

et al. 2020

Biotechnology and Applied Biochemistry

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Diabetic foot ulcers (DFUs) are chronic severe complications of diabetes disease and remain a worldwide clinical challenge with social and economic consequences. Diabetic wounds can cause infection, amputation of lower extremities, and even death. Several factors including impaired angiogenesis, vascular insufficiency, and bacterial infections result in a delayed process of wound healing in diabetic patients. Treatment of wound infections using traditional antibiotics has become a critical status. Thus, finding new therapeutic strategies to manage diabetic wounds is urgently needed. Nanotechnology has emerged as an efficient approach for this purpose. This review aimed to summarize recent advances using nanotechnology for the treatment of diabetic wounds.

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Section: Resultsmentioning

confidence: 99%

“…Increased antibiotic resistance in microorganisms has made the treatment of DFUs a major challenge. Thus, new antimicrobial agents and novel wound dressings are urgently needed [22].…”

Section: Introductionmentioning

confidence: 99%

Nanotechnology‐driven advances in the treatment of diabetic wounds

Zare

Rezayi

Aryan

et al. 2020

Biotechnology and Applied Biochemistry

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“…Therefore, debridement is important and effective to remove the biofilm for the treatment of DFU. Recurrent autologous platelet rich gel (APG) ( 32 ), negative pressure wound therapy (NPWT) ( 32 ), and S. nux-vomica–ZnO nanocomposite ( 34 ) may be effective treatments for MDR bacteria in patients with DFU.…”

Section: Discussionmentioning

confidence: 99%

Microbial Infection and Antibiotic Susceptibility of Diabetic Foot Ulcer in China: Literature Review

Gong

et al. 2022

Front. Endocrinol.

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ObjectiveTo investigate the microbial spectrum isolated from foot ulcers among diabetic patients in China, which was conducted to help clinicians choose optimal antibiotics empirically.MethodThe PubMed, MEDLINE, Web of Science, China Biology Medicine (CBM), China National Knowledge Infrastructure (CNKI), WanFang, and VIP databases were searched for studies published between 2015 to 2019, that report primary data on diabetic foot infection (DFI) and antibiotic susceptibility in China.ResultA total of 63 articles about DFI and antibiotic susceptibility tests among diabetic patients in China were included. There were 11,483 patients with an average age of 60.2 ± 10.1 years and a mean course of 10.6 ± 5.0 years between 2010 and 2019, covering most geographical regions of China. The prevalence of Gram-positive (GP) bacteria (43.4%) was lower than that of Gram-negative (GN) (52.4%). The most prevalent pathogens isolated were Staphylococcus aureus (17.7%), Escherichia coli (10.9%), Pseudomonas aeruginosa (10.5%), Klebsiella pneumoniae (6.2%), Staphylococcus epidermidis (5.3%), Enterococcus faecalis (4.9%), and fungus (3.7%). The prevalence of polymicrobial infection was 22.8%. GP bacteria were sensitive to linezolid, vancomycin, and teicoplanin. More than 50% of GN bacteria were resistant to third-generation cephalosporins, while the resistance rates of piperacillin/tazobactam, amikacin, meropenem, and imipenem were relatively low. Among the 6017 strains of the isolated organisms, 20% had multi-drug resistance (MDR). Staphylococcus aureus (30.4%) was the most predominant MDR bacteria, followed by extended-spectrum β-lactamase (ESBL) (19.1%).ConclusionThe microbial infection of foot ulcers among diabetic patients in China is diverse. The microbial spectrum is different in different geographic regions and Staphylococcus aureus is the predominant bacteria. Polymicrobial and MDR bacterial infections on the foot ulcers are common. This study could be valuable in guiding the empirical use of antibiotics for diabetic foot infections.

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“…The antimicrobial activity of ZnONPs confirmed that these NPs could be employed effectively as a better agent for biomedical applications. In this respect, Steffy et al [75] reported that ZnONPs act as a powerful antimicrobial agent against antibiotic-resistant bacterial pathogens, and for treating the non-healing ulcers. ZnONPs (with a size range of 10-12 nm) exhibited significant bactericidal efficiency against multidrug-resistant MDR-E. coli, MDR-P. aeruginosa, MDR-Enterococcus faecalis and Methicillin-resistant S. aureus.…”

Section: Antimicrobial Activity Of Znonpsmentioning

confidence: 99%

Microbial Mediated Synthesis of Zinc Oxide Nanoparticles, Characterization and Multifaceted Applications

Gomaa

2022

J Inorg Organomet Polym

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Nanoparticles have gained considerable importance compared to bulk counterparts due to their unique properties. Due to their high surface to volume ratio and high reactivity, metallic and metal-oxide nanostructures have shown great potential applications. Among them, zinc oxide nanoparticles (ZnONPs) have gained tremendous attention attributed to their unique properties such as low toxicity, biocompatibility, simplicity, easy fabrication, and environmental friendly. Remarkably, ZnONPs exhibit optical, physical, antimicrobial, anticancer, anti-inflammatory and wound healing properties. These nanoparticles have been applied in various fields such as in biomedicine, biosensors, electronics, food, cosmetic industries, textile, agriculture and environment. The synthesis of ZnONPs can be performed by chemical, physical and biological methods. Although the chemical and physical methods suffer from some disadvantages such as the involvement of high temperature and pressure conditions, high cost and not environmentally friendly, the green synthesis of ZnONPs offers a promising substitute to these conventional methods. On that account, the microbial mediated synthesis of ZnONPs is clean, eco-friendly, nontoxic and biocompatible method. This paper reviews the microbial synthesis of ZnONPs, parameters used for the optimization process and their physicochemical properties. The potential applications of ZnONPs in biomedical, agricultural and environmental fields as well as their toxic aspects on human beings and animals have been reviewed.

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Potential bactericidal activity of S. nux-vomica–ZnO nanocomposite against multidrug-resistant bacterial pathogens and wound-healing properties

Cited by 17 publications

References 48 publications

Nanotechnology‐driven advances in the treatment of diabetic wounds

Nanotechnology‐driven advances in the treatment of diabetic wounds

Microbial Infection and Antibiotic Susceptibility of Diabetic Foot Ulcer in China: Literature Review

Microbial Mediated Synthesis of Zinc Oxide Nanoparticles, Characterization and Multifaceted Applications

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